2026-10-28T02:55:30Zhttps://kostu-rdlopen.rawdatalibrary.net/oai/request

oai:kostu-rdlopen.rawdatalibrary.net:kostu/102282026-10-27T23:53:12Zopenairecom_kostu_10000col_kostu_10001com_kostu_10010col_kostu_10063

Development of Fluorimetric Method for Controlled Drug Release From Vinyl Propionate-co-Maleic Anhydride Polymer Modified With ParacetamolMemis, YilmazGunduz, S. BenizAltuner, Elif EsraTatli, Havva NurOzen, GurkanOkudan, AhmetCivil, SerifeDar, Umar Alicontrolled drug releasecopolymerfluorimetric methodparacetamolvinyl propionate-maleic anhydrideA novel pH-responsive polymeric drug delivery system is developed by covalently binding the active pharmaceutical ingredient paracetamol (PAR) to a synthesized vinyl propionate-co-maleic anhydride (VPR-co-MA) copolymer. The controlled release of PAR from the resulting VPR-co-MA-PAR conjugate was investigated in vitro at various physiological pH values (2.0, 4.5, 7.4, and 9.0) at 37°C over a 6 h-period. A fluorimetric method was utilized to quantify the released PAR, with optimal excitation and emission wavelengths determined to be 330 and 433 nm, respectively. The results demonstrated a distinct pH-dependent release profile. After 6 h, the cumulative drug release was significantly suppressed at acidic gastric pH 2.0 (42.23%), whereas it was substantially higher at neutral and alkaline conditions, reaching 71.29% at pH 7.4 and a maximum of 74.46% at pH 9.0. The pronounced difference in release rates confirms the system's ability to limit premature drug release in the stomach while promoting targeted delivery in the intestinal tract. This VPR-co-MA-PAR conjugate shows significant promise as a carrier for the controlled oral delivery of paracetamol.John Wiley and Sons Inc2026Articlehttps://rdlopen.rawdatalibrary.net/r/kostu/10228https://doi.org/10.1002/slct.732712365-6549enChemistrySelectinfo:eu-repo/semantics/closedAccessinfo:eu-repo/semantics/articlehttps://kostu-rdlopen.rawdatalibrary.net/tr/items/kostu/10228