2026-10-28T02:40:53Zhttps://kostu-rdlopen.rawdatalibrary.net/oai/request

oai:kostu-rdlopen.rawdatalibrary.net:kostu/108202026-10-27T23:53:26Zopenairedrivercom_kostu_10000col_kostu_10001com_kostu_10007col_kostu_10059

The lenalidomide derivative loaded and quercetin modified MIL-100 based novel drug delivery system for breast cancer treatmentÖzsoy, MuntehaTok, Yagmur PirincciEskiler, Gamze GuneyTok, FatihKarakus, SevgiOzsoy, YildizÖzacar, MahmutMIL-100 (Fe)QuercetinLenalidomide-like novel drug derivativeDrug delivery systemTriple negative breast cancerLenalidomide (L0) is an immunomodulatory agent with a range of effects, including anticancer and antiinflammatory activity, and is commonly utilized in treating multiple myeloma. A derivative of lenalidomide (L1) has been synthesized to enhance its effects and to target different cancer cell types. In this study, the lenalidomide derivative L1, with the chemical structure 1-[2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl]-3(p-tolyl)urea, was loaded onto a novel drug delivery system (DDS), and its activity was assessed towards triple-negative breast cancer cell lines (TNBC). MIL-100, a subclass of metal-organic framework (MOF) structures, was synthesized via a microwave-assisted hydrothermal method. MIL-100 was modified with quercetin (QC) as a linker, and its drug loading capacity was optimized, achieving a 95.18 % encapsulation efficiency. Additionally, the antioxidant properties of QC contributed to enhancing the performance of the DDS. In vitro drug release studies of the final product, MIL-100@QC@L1, were successfully conducted. The cytotoxic influences of the formulation on MDA-MB-231 cells were assessed using the WST-1 assay. After treatment with 10 mu g/mL of MIL100@QC@L1 for 24 h, the cell viability decreased significantly to 47.8 %, showing superior results compared to treatments with L0 and L1 alone.ELSEVIER2025-06Articlehttps://rdlopen.rawdatalibrary.net/r/kostu/10820https://doi.org/10.1016/j.jddst.2025.1069231773-2247enJOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGYinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://kostu-rdlopen.rawdatalibrary.net/tr/items/kostu/10820