Ay, Hilal; Sahin, Ozlem; Karakurt, Serdar; Altuner, Elif Esra; Aldemir, Ozan; Acar, Esra; Sahin, Mustafa

This study details the synthesis, characterization of unsymmetrical Schiff base ligand and their metal complexes Ni(II), Zn(II), Pb(II), and Cu(II) for anticancer assessment. These ligands were prepared by condensation reaction between 1,2-phenylenediamine in combinations with 2,5-dihydroxybenzaldehyde, 1-pyrenecarboxaldehyde, and 3-hydroxybenzaldehyde, producing distinctive molecular structures. Comprehensive analysis of their structural and electronic properties were conducted using elemental analysis, UV–Vis, FT-IR. 1H NMR, 13C-NMR spectroscopy, supplemented by magnetic moment measurements and fluorescence studies. The biological efficacy of the Schiff base derivatives was tested against DLD1 colon cancer cells, with cellular imaging employed to observe their effects. Notably, cytotoxicity assays showed IC50 values of 38.4 µM for ligand L1′and 7.3 µM for ligand L2′, indicating strong activity against colorectal carcinoma (CRC) cells. Significantly, both compounds exhibited minimal toxicity toward healthy epithelial cells (IC50 > 200 µM), demonstrating their selective anticancer potential.

İncele

Shahin, Musarat; Mohsin, Abdul Haseeb; Bibi, Aiman; Ahmad, Ihtisham; Altuner, Elif Esra; Aldemir, Ozan; Durmusoglu, Senol; Yilancilar, Mehmet Sabit; Tanriverdi, Yavuz; Acar, Esra

Substantial advances have been made since the 1970s in reducing the environmental impacts of ammonia production. Renewable-driven electrochemical synthesis offers a promising pathway to decarbonize ammonia production. This review examines an integrated route in which hydrogen is generated photoelectrochemically under concentrated solar irradiation and subsequently used in electrochemical ammonia synthesis. Photoelectrochemical cells are fabricated by electrostatically depositing photosensitive particles onto cathodes to enhance light-driven hydrogen production. Hydrogen production rates and ammonia yield depend strongly on temperature and electrolyte composition. The synthesized hydrogen is fed into a molten salt electrochemical reactor that operates at atmospheric pressure and receives nitrogen from a dedicated supply. This combined solar–electrochemical approach can produce low-carbon ammonia with improved safety and reduced environmental impact, offering a scalable alternative to conventional processes.

AtıfScopus1

İncele

Mohsin, Abdul Haseeb; Torlak, Yasemin; Altuner, Elif Esra; Aldemir, Ozan; Khan, Rasool; Issa, Ghassan; Zafar, Salman; Bibi, Aiman; Khan, Misbah Rafiq; Khan, Huma

A series of newly synthesized β-lactam conjugates of thiadiazine-2-thiones (TDZ-2T) were prepared by reacting various primary amines with carbon disulfide and potassium hydroxide, followed by the addition of formaldehyde and β-lactam antibiotics, including cefaclor and cefadroxil, in phosphate buffer. The synthesized substances were evaluated for their in vitro antimicrobial activity against P. aeruginosa and E. coli. All the substances exhibited activity against each forms of bacterial types, with 1e, 1f, 1g, 2a, and 2b showing the most significant activity. Additionally, the anti-nociceptive impact of the prepared substances was analyzed by the hot plate technique. Substances 1a, 1b, 1d, 1f, 1g, and 2a demonstrated notable activity at dosages of 80 mg/kg, as evidenced by a significant enhancement during the lag phase. Intact binding studies of the synthesized substance were also performed and showed a good binding interaction with the binding site of the in silico cyclooxygenase-2 (COX) enzyme.

AtıfScopus1

İncele

Altuner, Elif Esra; Issa, Ghassan; Ozalp, Veli Cengİz; Aldemir, Ozan; Torlak, Yasemin; Dar, Umar Ali

This chapter provides a detailed explanation of the clinical investigations, pharmacological effects, and characteristics of quinone and quinone derivatives, along with references to pertinent sources. Although quinones have an oxygen group in their structure, they are quickly oxidized and interact with reactive oxygen species. This demonstrates how quinones work as drugs. Quinones and their derivatives are used as medications to treat a wide range of diseases, including cancer, lung, kidney, brain, and tumor disorders. Each of the following has effects on a different area of health; lapochols, anthraquinones, naphthoquinone and its derivatives, and other wide range of quinone derivatives are thoroughly explored in this chapter.

İncele

Duru, Özlem Ateş; Araç, Fatma Özsel Özcan; Aldemir, Ozan

Rocket salad (Eruca .sativa), a member of the Brassicaceae family, is an important vegetable for human health because of its antioxidant, anti-inflammatory, anticancer, antiproliferative, and antiangiogenesis properties, as well as its rich chemical composition. Important phytochemical substances in rocket salad, including flavonoids and glucosinolates, have an important function in human health protection. These components can scavenge free radicals, reduce lipid peroxidation, and have anticancer effects by activating apoptosis in cancer cells. As a result, in terms of defending human health, it is believed that the consumption of this vegetable has a significant role in protecting against diseases caused by numerous factors and in the healthy functioning of the body's immune system.

AtıfScopus4

İncele