Sürdürülebilir Kalkınma Amaçları

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• MakaleAçık Erişim2026Scopus SJRQ3/r/kostu/10612
  Synthesis, Characterization, and Anticancer Activity of Pyrene-Based Schiff Base Ligands and Their Transition Metal Complexes

  Ay, Hilal; Sahin, Ozlem; Karakurt, Serdar; Altuner, Elif Esra; Aldemir, Ozan; Acar, Esra; Sahin, Mustafa

  This study details the synthesis, characterization of unsymmetrical Schiff base ligand and their metal complexes Ni(II), Zn(II), Pb(II), and Cu(II) for anticancer assessment. These ligands were prepared by condensation reaction between 1,2-phenylenediamine in combinations with 2,5-dihydroxybenzaldehyde, 1-pyrenecarboxaldehyde, and 3-hydroxybenzaldehyde, producing distinctive molecular structures. Comprehensive analysis of their structural and electronic properties were conducted using elemental analysis, UV–Vis, FT-IR. 1H NMR, 13C-NMR spectroscopy, supplemented by magnetic moment measurements and fluorescence studies. The biological efficacy of the Schiff base derivatives was tested against DLD1 colon cancer cells, with cellular imaging employed to observe their effects. Notably, cytotoxicity assays showed IC50 values of 38.4 µM for ligand L1′and 7.3 µM for ligand L2′, indicating strong activity against colorectal carcinoma (CRC) cells. Significantly, both compounds exhibited minimal toxicity toward healthy epithelial cells (IC50 > 200 µM), demonstrating their selective anticancer potential.

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• MakaleYalnız künye2026Scopus SJRQ3/r/kostu/10228
  Development of Fluorimetric Method for Controlled Drug Release From Vinyl Propionate-co-Maleic Anhydride Polymer Modified With Paracetamol

  Memis, Yilmaz; Gunduz, S. Beniz; Altuner, Elif Esra; Tatli, Havva Nur; Ozen, Gurkan; Okudan, Ahmet; Civil, Serife; Dar, Umar Ali

  A novel pH-responsive polymeric drug delivery system is developed by covalently binding the active pharmaceutical ingredient paracetamol (PAR) to a synthesized vinyl propionate-co-maleic anhydride (VPR-co-MA) copolymer. The controlled release of PAR from the resulting VPR-co-MA-PAR conjugate was investigated in vitro at various physiological pH values (2.0, 4.5, 7.4, and 9.0) at 37°C over a 6 h-period. A fluorimetric method was utilized to quantify the released PAR, with optimal excitation and emission wavelengths determined to be 330 and 433 nm, respectively. The results demonstrated a distinct pH-dependent release profile. After 6 h, the cumulative drug release was significantly suppressed at acidic gastric pH 2.0 (42.23%), whereas it was substantially higher at neutral and alkaline conditions, reaching 71.29% at pH 7.4 and a maximum of 74.46% at pH 9.0. The pronounced difference in release rates confirms the system's ability to limit premature drug release in the stomach while promoting targeted delivery in the intestinal tract. This VPR-co-MA-PAR conjugate shows significant promise as a carrier for the controlled oral delivery of paracetamol.

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• MakaleYalnız künye2025Scopus SJRQ3/r/kostu/10577
  Thermodynamic and Kinetic Performance of Highly Efficient ZnO/Co@f-MWCNT Catalysts for Hydrogen Production

  Mashkoor, Hussein; Gulbagca, Fulya; Tiri, Rima Nour Elhouda; Altuner, Elif Esra; Halvaci, Ebru; Bennini, Nihed; Doner, Nimeti; Sen, Fatih

  The use of catalysts is one of the most important parameters in producing hydrogen energy. Zinc-oxide/cobalt nanoparticles were synthesized by chemical methods and doped on f-MWCNT (ZnO/Co@f-MWCNT NPs) as a supporting material. Various characterization techniques were used to examine the structural and morphological properties of the synthesized nanoparticles (ZnO/Co@f-MWCNT NPs). According to the XRD characterization results, the average crystal particle size of NPs was calculated as 2.10 nm, and according to TEM analysis, the average particle size was calculated to be 2.24 ± 0.5 nm. The catalytic activity of ZnO/Co@f-MWCNT NPs toward hydrogen production was determined using NaBH4 as the hydrogen source. Studies were carried out on how the catalytic activity of ZnO/Co@f-MWCNT NPs would vary in different parameters. The average reusability performance achieved after 4 cycles for hydrogen production is 89%. Turnover frequency (TOF) according to catalytic activity, activation energy (Ea), enthalpy (∆H), and entropy (∆S) were found to be 2467.4 min−1, 16.36 kj/mol, 13.79 kj/mol and -122.8 J/mol.K, respectively. This study provides guidance for hydrogen production, and other energy studies, and supporting agents in the future.

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