Sürdürülebilir Kalkınma Amaçları

• 2

• MakaleAçık Erişim2025Scopus SJRQ2/r/kostu/10532
  Lens Proteomics Provide Novel Clues for Cataractogenesis: Original Investigation and a Broad Literature Survey

  Cosar, Banu; Nefesoglu, Mustafa Sehvar; Altinoz, Meric A.; Akgun, Emel; Sahin, Betul; Baykal, Ahmet; Serteser, Mustafa

  Background: Previous proteomic studies provided valuable information about cataracts, but unclarified issues, such as sex and ethnicity-associated differences, remain. This study aimed to provide additional data on cataract-related proteins regarding age, sex, and cataract type. Methods: Twenty-six female and seven male Turkish cataract patients were screened for visual acuity and dysfunctional lens index. A nano-LC-MS/MS system and Progenesis QI software v3.0 were used for protein identification and quantification. The remaining data were evaluated with SPSS Version 29.0 software. Results: Proteins that showed age-associated changes were mainly involved in cytoskeletal organization. A glyoxalase enzyme, caveolin 1, and HS90B were lower, and RAB8B and ATP6V1B1 were higher in lenses in women. Proteins with lower levels in cataractous lenses than in transparent lenses included filensin and phakinin, concurrent with previous publications, and LCTL, GDI, HSPB1, and EIF4A2, not reported before. Corticonuclear cataracts constituted the only group showing depletions in putatively protective proteins, while the cortical type was the least influenced. ANXA1 and DNHD1 positively, and TCPD, SEC14L2, and PRPS1 proteins negatively correlated with visual acuity. Conclusions: This study revealed cataract-related proteins concurrent with earlier studies and new ones hitherto unreported. Despite the low number of patients investigated, the results merit further research, as these new proteins are highly likely to be involved in cataractogenesis.

  • 
  AtıfScopus4·WoS4·OpenAlex4

  İncele
• MakaleAçık Erişim2025Scopus SJRQ2/r/kostu/10313
  The Impact of Femoral Anteversion Correction on Clinical Outcomes in Total Hip Arthroplasty for Adult Developmental Dysplasia of the Hip

  Satılmış, Ahmet Burak; Cengiz, Tolgahan; Ülker, Ahmet; Mutlu, Tansel

  Background: Total hip arthroplasty (THA) in adult patients with developmental dysplasia of the hip (DDH) presents unique surgical challenges due to altered hip anatomy and biomechanics. One of the most critical factors influencing surgical success is correcting femoral anteversion. This study evaluates the effects of different anteversion corrections (increased, unchanged, and decreased) during THA on clinical outcomes in adult Crowe type 3-4 DDH patients. Methods: A retrospective analysis was conducted on 130 patients who underwent THA with anteversion correction between 2008 and 2017 at a tertiary university hospital. Patients were divided into three groups: Group 1 (increased anteversion), Group 2 (unchanged anteversion), and Group 3 (decreased anteversion). Clinical outcomes were assessed using AOFAS and Lysholm scores, Q-angle measurements, and physical examinations, while radiological evaluations were performed to determine implant stability and complications. Results: Postoperative assessments show that increased anteversion is associated with higher rates of instability, knee dysfunction, and pain. Group 1 had significantly lower AOFAS scores (p < 0.001) and fell due to rotational deformity (25.6%). Group 2 exhibited the best clinical outcomes, with the lowest rates of instability and the highest functional scores. Group 3 had moderate functional improvements but a higher dislocation rate (17.1%) than Group 2. Conclusions: Our findings suggest that excessive changes in femoral anteversion during THA, remarkably increasing it, may negatively impact clinical outcomes by causing instability and pain. Preserving the anteversion angle as much as possible is the most favorable approach for optimizing functional recovery and implant stability. Further large-scale, long-term studies are required to confirm these findings and refine surgical strategies for DDH patients undergoing THA.

  AtıfScopus10·WoS11

  İncele
• MakaleAçık Erişim2025Scopus SJRQ2/r/kostu/10250
  Associations Between Pulmonary Function and Muscle Strength in Turkish National Karate Athletes

  Tokgoz, Gurkan; Cinarli, Sena; Akyol, Betül; Aygoren, Caner; Beykumul, Aysegul; Larsen, Malte Nejst; Krustrup, Peter; França, Cíntia; Gouveia, Élvio Rúbio; Cinarli, Fahri Safa

  Background: Respiratory efficiency is considered important in karate due to its role in sustaining muscular performance during high-intensity actions. This study examined the association between pulmonary function and isometric muscle strength in national-level karate athletes. Methods: A total of 23 elite karate athletes (mean age: 23.0 ± 2.3 (mean ± SD) years) participated in the study. Pulmonary function was assessed using a digital spirometer, while isometric handgrip, lower back, and leg strength were measured using a dynamometer. The correlation between pulmonary function and isometric strength was analyzed, and linear regression was employed to examine the predictive capacity of pulmonary parameters for muscle strength. Results: The results revealed significant correlations, ranging from large to very large, between pulmonary function and isometric muscle strength, with correlation coefficients from 0.639 to 0.812 (p < 0.01). Pulmonary function was strongly associated with isometric strength, accounting for 27% to 67% of the variance (p < 0.05). Multiple regression analysis revealed that pulmonary function parameters accounted for 71% of the variance in handgrip strength, 47% in leg strength, and 71% in back strength (p < 0.05). Conclusions: These findings highlight the strong associations between pulmonary function and isometric muscle strength in elite karate athletes. The results emphasize the importance of pulmonary health and respiratory muscle function in athletic performance, particularly for sports requiring high-intensity, dynamic movements like karate. Future longitudinal studies are needed to explore the mechanisms underlying the association and potential implications, and for training and performance optimization.

  • 
  İncele
• Derleme MakaleAçık Erişim2024Scopus SJRQ1/r/kostu/10692
  Myval Transcatheter Heart Valve: The Future of Transcatheter Valve Replacement and Significance in Current Timeline

  Kilic, Teoman; Coskun, Senol; Mirzamidinov, Didar; Yilmaz, Irem; Yavuz, Sadan; Sahin, Tayfun

  The Myval is a balloon-expandable transcatheter heart valve (THV) developed by Meril Life Sciences Pvt. Ltd. (Vapi, Gujarat, India) that has an innovative operator-friendly design that aids in improving deliverability and features precise deployment. Various clinical studies demonstrate its effectiveness and safety, making it a promising choice in valvular interventions. Myval has been successfully utilized as a transcatheter aortic valve implantation (TAVI) device in cases with conduction disturbances, bicuspid aortic valve anatomy, non-calcified aortic regurgitation, dysfunctional stenosed right ventricular outflow tract (RVOT) conduits, pulmonary valve replacement, mitral valve replacement, and valve-in-valve and valve-in-ring implantation procedures. Myval’s diverse sizes are also of key importance in complex cases of large annuli and complex anatomy. Further long-term studies are needed to consolidate these results. Its introduction signifies a significant advancement in cardiology, aiming to enhance patient outcomes and quality of life. In the present review, we provide an update on new-generation Myval THV series and review the available clinical data published to date with an emphasis on diverse use in specific clinical scenarios.

  AtıfScopus13·WoS13

  İncele