Sürdürülebilir Kalkınma Amaçları

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• MakaleYalnız künye2025Scopus SJRQ2/r/kostu/10624
  Synthesis, characterization and biological evaluation of new Coumarin-Ferrocene conjugates as antitumor agents

  Taner, Bilge; Mahmood Mahmood, Aysha Hasan; Karakurt, Serdar; Altuner, Elif Esra; Dar, Umar Ali

  Two novel ferrocene-appended coumarin derivatives, FcL1 and FcL2, were synthesized and characterized using various analytical techniques which includes IR, UV, 1H NMR, 13C NMR and mass spectroscopy. 1H NMR revealed signals for the substituted cyclopentadiene ring at δ 4.80 and δ 4.61 ppm (FcL1) and δ 4.81 and 4.60 ppm (FcL2), while 13C NMR confirmed azomethine carbons at δ 162.95 and 160.43 ppm, respectively. UV–Vis analysis confirmed the successful molecular design of FcL1 and FcL2, achieving the desired electronic properties. Cytotoxic and antiproliferative effects of FcL1 and FcL2 were evaluated against metastatic colorectal carcinoma (CRC) DLD-1 cells and healthy colon epithelium CCD-18Co cells using the Alamar Blue assay. Both compounds inhibited DLD-1 cell proliferation in a dose-dependent manner, with IC50 values of 64.3 ± 2.4 µM (FcL1) and 67.1 ± 3.1 µM (FcL2). Minimal cytotoxic effects were observed on healthy colon epithelial cells at the same concentrations (p < 0.001). Fluorescence microscopy revealed the localization of both compounds in the cytoplasm and nucleus of cells. These findings suggest FcL1 and FcL2 as potential candidates for colorectal cancer therapy, exhibiting selective cytotoxicity toward cancer cells with low toxicity to healthy cells.

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  AtıfScopus8·WoS6·OpenAlex7

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• MakaleYalnız künye2024Scopus SJRQ3/r/kostu/10367
  A fully conjugated imidazole-fused perylene phenantroline ruthenium(II) complex in photocatalytic oxidation

  Aksakal, Nuray Esra; Aksakal, Fatma; Gül, Elif Yıldız; Eçik, Esra Tanrıverdi; Yuksel, Fatma

  In this investigation, the suitability of a specially designed imidazole-fused perylene ruthenium(II) molecule, denoted as Ru-PhP, was explored by employing the photooxidation of 1,5-dihydroxynaphthalene (DHN) to produce Juglone as a model reaction. This distinctive, entirely conjugated compound was synthesized through the reaction between perylene imide anhydride dye (1) and a ruthenium(II) phenanthroline complex (2) in the presence of a Zn(OAc)2 catalyst. Structural analyses of the compound were performed by using general spectroscopic methods including FT-IR, 1H NMR, 13C- NMR, and MALDI-TOF analyses. Various photophysical properties, including the UV–Vis absorption spectrum, fluorescence emission spectrum, and fluorescence quantum yield, were examined. The photochemical studies via indirect method endorsed Ru-PhP as an efficient photosensitizer. Furthermore, Ru-PhP proved to be highly effective in facilitating the photooxidation of DHN to yield juglone. DFT-based natural bond orbital analysis revealed intramolecular charge transfer in Ru(II) coordination environment, with a strong total stabilization energy (25.31 eV) between the ruthenium acceptor and nitrogen donors in the bipyridine and phenanthroline units. The dispersion of HOMO electrons within the imidazole-bridged perylene moiety and the localization of LUMO electrons near Ru(II)-coordinated bipyridine units were observed through Frontier Molecular Orbital and molecular electrostatic potential analyses. Ru-PhP is proposed as photocatalyst for photo redox catalytic organic reactions.

  AtıfScopus2·WoS2·OpenAlex2

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