Sürdürülebilir Kalkınma Amaçları
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- MakaleYalnız künye2026Scopus SJRQ1Preservation of septal cartilage for early revisions: a histopathological study
Hancı, Deniz; Kumaş, Ömer; Turgut, Hüseyin; Çelik, Cem; Uygan, Uğur; Altun, Hüseyin; Onaran, Öykü İzel; Gürpınar, Berk; Obuz, Mert; Uyar, Yavuz
Objective: To determine how storage medium and temperature affect the histological viability of autologous septal cartilage intended for early revision rhinoplasty. Methods: Cartilage specimens stored for 6 and 12 months in four media—dry, gentamicin, cefazolin, and saline—at two distinct temperatures underwent histopathological evaluation after paraffin embedding. The assessed parameters were graft viability, fibrosis, osteoid metaplasia, and peripheral chondroid proliferation. Results: Among 480 septal cartilage specimens harvested from 30 patients, overall viability fell from 62 ± 15% at 6 months to 44 ± 14% at 12 months (p < 0.001), while fibrosis, osteoid metaplasia, and peripheral chondroid proliferation all increased significantly (each p < 0.001). Viability declined in every storage condition, but grafts kept at − 80 °C or in saline-based solutions deteriorated fastest, reaching a mean viability of 39% versus 53% for dry storage at − 20 °C at 12 months. Multivariate analysis confirmed − 80 °C storage (OR 2.3, 95% CI 1.4–3.8) and saline media (OR 1.9, 1.1–3.4) as independent predictors of poor viability (< 40%), whereas antibiotic additives were not protective. Histological evidence of osteoid metaplasia (OR 3.6, 1.9–6.8) and peripheral chondroid proliferation (OR 2.1, 1.2–3.7) strongly predicted non-viable grafts. A linear mixed-effects model demonstrated additive negative effects of − 80 °C and saline on both baseline viability and its rate of decline (marginal R² = 0.52). Dry storage at − 20 °C yielded the most favorable long-term viability. Conclusion: Dry storage of autologous septal cartilage at − 20 °C preserves graft viability well enough to offer a cost-effective alternative for early revision surgeries, warranting confirmation in prospective clinical trials.
- MakaleAçık Erişim2025Scopus SJRQ3PRP and Diced Cartilage-Enhanced Fascia Lata: A Composite Graft for Septal Perforation Repair
Hanci, Deniz; Onaran, Öykü İzel; Altun, Hüseyin; Bozer, Berke Berat; Gürpınar, Berk; Obuz, Mert; Baş, Merih Cem; Topalan, Veysel; Tolga, Yiğit; Gültepe Zorlu, Tuğçe
Objective: Nasal septal perforation (NSP) is characterized by defects in the mucosal, cartilaginous, and bony structures of the septum, most commonly resulting from septoplasty. Spontaneous healing of NSPs is rare, necessitating surgical intervention once the condition stabilizes. Numerous techniques have been developed for NSP repair. This study presents a novel technique combining fascia lata grafts, platelet-rich plasma (PRP), and diced septal cartilage harvested from the patient’s remaining deviated nasal septum for the repair of medium-sized NSPs. Methods: A retrospective analysis was conducted on 32 patients who underwent NSP repair between July 2022 and July 2023. The repair utilized fascia lata, PRP derived from venous blood, and diced cartilage from residual septal cartilage. The procedure involved an open rhinoplasty approach for graft placement, followed by stabilization using endoscopic techniques. Results: The mean horizontal and vertical diameters of the septal perforations were 12.06 ± 2.87 mm and 13.12 ± 2.44 mm, respectively. All patients had medium-sized perforations (0.5-2 cm). The mean follow-up period was 12.03 ± 1.11 months. Complete closure was achieved in 28 of 32 cases (87.5%). The cohort included 18 males (56.3%) and 14 females (43.8%), with a mean age of 35.47 ± 5.31 years (range: 25-45). Ten patients (31.3%) were smokers, among whom 4 experienced incomplete closure. Smoking was not significantly associated with repair failure (P = .06). Conclusion: This novel technique combining fascia lata, PRP, and diced septal cartilage offers a reliable and effective approach for the repair of medium-sized NSPs. © The Author(s) 2025. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
- Kitap BölümüYalnız künye2025ABCLOVE Rehabilitation for Vocal Nodules
Altun, Hüseyin
The vocal cords can develop noncancerous nodules, which can cause various symptoms, such as hoarseness, changes in voice quality, pain (such as a sharp ache in the neck or jaw), and so on. A vocal nodule is a prevalent symptom in children, affecting 38–78% of children with hoarseness and 3–26% with vocal problems overall. The long-term effects of voice abuse or misuse are the most common cause of vocal nodules in children. These vocal habits can harm the vocal cords and even cause benign tumors to develop because of the friction that occurs between the vocal folds. Kids with vocal nodules have a worse quality of life, and their physical health takes a hit. Anxiety and despair are common in children who have voice nodules. Vocal nodule removal surgery and medicinal treatment are two therapeutic alternatives for treating vocal nodules. Operating on youngsters is more complex than on adults. Budesonide inhalation is one medicinal treatment that has been shown to alleviate inflammation and pain associated with vocal nodules. Nevertheless, adverse effects, particularly on children’s growth, may occur with long-term inhalation therapy of Budesonide. On the other hand, voice therapy’s efficacy in treating vocal nodules in children has made it a hot topic in recent years.
- MakaleYalnız künye2024Scopus SJRQ1Fascia Lata-Fat Island Graft in Septal Perforation Repair
Hancı, Deniz; Çelik, Cem; Altun, Hüseyin; Uyar, Yavuz
Objective: To measure the success of the fascia lata-fat island graft technique in septal perforation repair as measured by nasal endoscopic examination. Background: This study presents the results of using fascia lata-fat island, a different graft technique, for the repair of septal perforations, offering an alternative to this challenging procedure. Methods: This retrospective study assesses nasal septal perforation repair using the fascia lata-fat island graft technique performed by a single surgeon. Inclusion criteria involved completing 12-month follow-ups within a 3-year review period. Success rates were calculated and evaluated alongside patient characteristics. Results: The median (range) age of the 25 patients included in the study was 34 (25-45) years and 72.0% were men. The septal perforation size of all patients was >2 cm and the etiological cause in all of them was previous septal surgery. All patients were followed for 12 months. The perforation was completely closed in 23 of 25 patients (92%). Conclusion: Using a different graft with an open rhinoplasty approach, we achieved a high success rate in patients with large septal perforations, followed for 1 month with nasal stenting and an average follow-up duration of 12 months. Copyright 2024, American Academy of Facial Plastic and Reconstructive Surgery, Inc.
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