Sürdürülebilir Kalkınma Amaçları
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- MakaleYalnız künye2026Scopus SJRQ3Biogenic Silver Nanoparticles from Citrus reticulata Peels for Ultrasensitive Electrochemical Sensing of 4-Aminobenzenesulfonamide
Dar, Umar Ali; Altuner, Elif Esra; Akocak, Suleyman; Issa, Ghassan; Ozalp, Veli Cengiz
Increasing utilization of sulfonamide derivatives as antibacterial agents has created serious challenges in terms of environmental pollution and antimicrobial resistance. In this respect, there is a compelling need for a highly sensitive and selective analytical tool for detecting such antibiotics in trace concentrations. This work represents a green strategy for developing an electrochemical biosensor for the determination of 4-aminobenzenesulfonamide based on bio-functionalized silver nanoparticles (Ag NPs) prepared from peel extract of Citrus reticulata fruit. The phytochemicals present in the peel extracts played a dual role of reduction and stabilization during the synthesis of Ag NPs. Synthesized NPs were well characterized through scanning electron microscopy (SEM), X-ray diffraction (XRD), Ultraviolet spectroscopy (UV–Vis), and Fourier infrared spectroscopy (FTIR) techniques. The Ag NPs showed considerable improvement in electrocatalysis in comparison to the bare glassy carbon electrode. The fabricated sensor gave an excellent linear calibration curve with a high value of R2 (=0.999), along with a low limit of detection (LOD = 0.65 µM) and limit of quantification (LOQ = 2.1 µM).
- MakaleYalnız künye2026Scopus SJRQ3Development of Fluorimetric Method for Controlled Drug Release From Vinyl Propionate-co-Maleic Anhydride Polymer Modified With Paracetamol
Memis, Yilmaz; Gunduz, S. Beniz; Altuner, Elif Esra; Tatli, Havva Nur; Ozen, Gurkan; Okudan, Ahmet; Civil, Serife; Dar, Umar Ali
A novel pH-responsive polymeric drug delivery system is developed by covalently binding the active pharmaceutical ingredient paracetamol (PAR) to a synthesized vinyl propionate-co-maleic anhydride (VPR-co-MA) copolymer. The controlled release of PAR from the resulting VPR-co-MA-PAR conjugate was investigated in vitro at various physiological pH values (2.0, 4.5, 7.4, and 9.0) at 37°C over a 6 h-period. A fluorimetric method was utilized to quantify the released PAR, with optimal excitation and emission wavelengths determined to be 330 and 433 nm, respectively. The results demonstrated a distinct pH-dependent release profile. After 6 h, the cumulative drug release was significantly suppressed at acidic gastric pH 2.0 (42.23%), whereas it was substantially higher at neutral and alkaline conditions, reaching 71.29% at pH 7.4 and a maximum of 74.46% at pH 9.0. The pronounced difference in release rates confirms the system's ability to limit premature drug release in the stomach while promoting targeted delivery in the intestinal tract. This VPR-co-MA-PAR conjugate shows significant promise as a carrier for the controlled oral delivery of paracetamol.
- MakaleYalnız künye2025Scopus SJRQ3Synthesis and Characterization of Iron-Cobalt@Activated Carbon Nanoparticles for Electrochemical Sensing of Dopamine Neurotransmitters
Altuner, Elif Esra; Janabi, Muhammad Yousif Ali Al; Sen, Fatih; Dar, Umar Ali
Activated carbon-supported FeCo@AC nanoparticles (FeCo@ACNPs) were synthesized for catalytic activity and extend shelf life by incorporating bimetallic iron-cobalt nanoparticles (FeCoNPs). The synthesized nanoparticles were characterized using fourier-transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and X-ray diffraction (XRD) to elucidate their structural and morphological properties. FTIR analysis confirmed the presence of metal nanoparticles with characteristic peaks at 590–612 cm⁻¹. TEM analysis revealed an average nanoparticle size of 10.71 ± 3.52 nm, while XRD results indicated crystalline dimensions of 7.2 nm. FeCo@ACNPs were further modified onto a glassy carbon electrode, and their sensor activity was evaluated for dopamine detection in the linear range of 0.1–1 mM. The study determined a limit of detection (LOD) of 0.65 µM and a limit of quantification (LOQ) of 1.97 nM. These findings not only reinforce previous studies on dopamine sensing but also provide valuable understanding of dopamine sensing and highlight its potential for health applications, particularly in diagnosing neurological disorders like Parkinson’s disease by monitoring dopamine levels.
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İncele - MakaleYalnız künye2025Scopus SJRQ2Synthesis, characterization and biological evaluation of new Coumarin-Ferrocene conjugates as antitumor agents
Taner, Bilge; Mahmood Mahmood, Aysha Hasan; Karakurt, Serdar; Altuner, Elif Esra; Dar, Umar Ali
Two novel ferrocene-appended coumarin derivatives, FcL1 and FcL2, were synthesized and characterized using various analytical techniques which includes IR, UV, 1H NMR, 13C NMR and mass spectroscopy. 1H NMR revealed signals for the substituted cyclopentadiene ring at δ 4.80 and δ 4.61 ppm (FcL1) and δ 4.81 and 4.60 ppm (FcL2), while 13C NMR confirmed azomethine carbons at δ 162.95 and 160.43 ppm, respectively. UV–Vis analysis confirmed the successful molecular design of FcL1 and FcL2, achieving the desired electronic properties. Cytotoxic and antiproliferative effects of FcL1 and FcL2 were evaluated against metastatic colorectal carcinoma (CRC) DLD-1 cells and healthy colon epithelium CCD-18Co cells using the Alamar Blue assay. Both compounds inhibited DLD-1 cell proliferation in a dose-dependent manner, with IC50 values of 64.3 ± 2.4 µM (FcL1) and 67.1 ± 3.1 µM (FcL2). Minimal cytotoxic effects were observed on healthy colon epithelial cells at the same concentrations (p < 0.001). Fluorescence microscopy revealed the localization of both compounds in the cytoplasm and nucleus of cells. These findings suggest FcL1 and FcL2 as potential candidates for colorectal cancer therapy, exhibiting selective cytotoxicity toward cancer cells with low toxicity to healthy cells.
AtıfScopus8WoS6OpenAlex7İncele - Kitap BölümüYalnız künye2025Porphyrin composite materials analysis, design, manufacturing and production
Altuner, Elif Esra; Sen, Fatih; Dar, Umar Ali
This chapter explains the analysis, design, and production of porphyrin-induced derivatives with reference to the relevant sources. Porphyrin has a colorful structure by altering the position of these rings, porphyrin derivatives can be formed, and metals can be included in complex structures. The analysis of porphyrin is conducted under three main headings volta metric analysis, spectro photometric analysis, and HPLC analysis. Chlorines and bacterioclorines, n-substituted por-phytes, aza porphytes, ftalocyanins, and purpurines are analogs of porphyrins. The production of porphyrin varies based on synthesis methods. These differences arise from aldehydes and ketones, and dipiromethan A2BC tetra-substituted por-phyrin, trans-substituted porphyrin synthesis, and symmetrical meso-substituted synthesis methods have been discussed.
- Kitap BölümüYalnız künye2025Advanced characterization methods and characterization types for porphyrins
Altuner, Elif Esra; Sen, Fatih; Dar, Umar Ali
This chapter delves into the comprehensive structural descriptions of porphyrins, focusing on their physico-chemical features. The chapter offers a comprehensive description of the numerous analytical techniques used in the characterization and methodologies for structural determination. This encompasses NMR (H-NMR and C-NMR), Raman, and UV-Vis. TEM, AFM, and DLS were utilized to examine their topography and morphology. Every characterization technique is thoroughly described, with each component highlighted in separate sections.
- Kitap BölümüYalnız künye2025Scopus SJRQ4Waste Dye Removal with Nanotechnological Methods: Photocatalytic Processes
Altuner, Elif Esra; Tatli, Havva Nur; Aldoori, Bakr; Dar, Umar Ali
This chapter discusses how photocatalytic processes using nanotechnology can counteract the harm done to the environment by waste dyestuffs from industry combining with water, soil, and the environment. When waste dyestuffs from the business mingle with soil and drinking water, they pose a serious hazard to life. For this reason, it is of great importance to remove and neutralize waste dyes with the photocatalyst effect of sunlight and the synergistic effect of nanocatalysts synthesized through nanotechnological means. The photocatalysis process is both environmentally friendly and of great importance to living things. This chapter is also informative about photocatalysis research carried out by nanoparticles under the influence of sunlight.
AtıfScopus2OpenAlex1İncele - Kitap BölümüYalnız künye2025Role and scope of porphyrin composites in biotechnology
Altuner, Elif Esra; Issa, Ghassan; Sen, Fatih; Dar, Umar Ali
In this chapter, the roles of porphyrins and their derivatives in daily life, their application areas, and their importance in medical imaging for target regions and cell detection are discussed. Porphyrins are structures that can adapt to biotechnological studies due to their structures. Therefore, it is of great importance in biotechnology, especially in medical imaging. Detection of the defective region in magnetic resonance imaging, determination of the target by moving the porphyrins using rays in the photoacoustic region, or the emergence of a colored label with the fluorescence technique are the most important advantages of porphyrins. Therefore, the importance of porphyrins in today's technology, especially in medical imaging, will support future technological studies.
- Kitap BölümüYalnız künye2024Analytical techniques for the characterization of quinone-based materials
Altuner, Elif Esra; Sen, Fatih; Dar, Umar Ali
Quinone is a compound that has a ring structure and contains oxygen in its body and is found in living things and plants. Being antibacterial and antifungal is an important advantage for living things, but it becomes a threat that causes deadly diseases for living things, due to the cyclic structure and oxygen molecule reacting with UV rays and various chemicals. For this reason, the detection of quinone and quinone-based materials is very important. The determination of quinone and quinone materials is provided by utilizing various characterization techniques such as electrochemical studies, UV-Vis studies, HPLC, and FTIR. This chapter presents a broad theoretical perspective to the literature by citing the relevant parts of quinone and quinone-based studies.
- Kitap BölümüYalnız künye2024Clinical development of quinone-based drugs
Altuner, Elif Esra; Issa, Ghassan; Ozalp, Veli Cengİz; Aldemir, Ozan; Torlak, Yasemin; Dar, Umar Ali
This chapter provides a detailed explanation of the clinical investigations, pharmacological effects, and characteristics of quinone and quinone derivatives, along with references to pertinent sources. Although quinones have an oxygen group in their structure, they are quickly oxidized and interact with reactive oxygen species. This demonstrates how quinones work as drugs. Quinones and their derivatives are used as medications to treat a wide range of diseases, including cancer, lung, kidney, brain, and tumor disorders. Each of the following has effects on a different area of health; lapochols, anthraquinones, naphthoquinone and its derivatives, and other wide range of quinone derivatives are thoroughly explored in this chapter.
- Kitap BölümüYalnız künye2024Commercialization of quinone-based drugs
Altuner, Elif Esra; Sen, Fatih; Dar, Umar Ali
In this chapter, the antibiotic drug effects of quinone and quinone derivatives are discussed in detail. Today, antibiotic drugs used against harmful pathogens work for a certain period, but these drugs become useless after a certain time or after a certain dose. This is because harmful microorganisms become resistant to these antibiotics after a certain threshold. For this reason, searches have been made that can replace antibiotics and are harmless. Quinone and quinone derivatives are one of these researches. Quinone and its derivatives show antibacterial, antiviral, and antifungal properties against various microorganisms. Quinones have the structure of cyclic diketones. Therefore, it is an advantage that it gives radicals easily as it resonates easily and thus has antioxidant properties in this reaction. The main quinone-based drugs used as antibiotic drugs are as follows: anthracyclines, mitomycin C, mitoxantrone, aziridinylbenzoquinones, streptonigrin, lapachols, and actinomycin D. Some of these drugs have anticancer and some have antitumor properties. This chapter can offer details on quinone and quinone derivatives-related commercial drug research.
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