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- MakaleAçık Erişim2025Scopus SJRQ2Evaluation of the effect of subclinical hypothyroidism on retinal blood flow. OCT angiography study
Gunes, Irfan Botan; Onal, Eda Demir
Purpose: To evaluate retinal blood flow and retinal nerve fiber layer (RNFL) thickness in untreated subclinical hypothyroid patients by optical coherence tomography angiography (OCT-A). Methods: Forty-four eyes of 44 patients in the subclinical hypothyroidism group (SCHG) and 42 eyes of 42 healthy subjects in the control group (CG) were included in the study. Macular superficial retinal blood flow (SRBF), peripapillary RNFL thickness and optic nerve head cup to disk ratio (C/D) were measured and recorded by OCT angiography and compared between the patient and control groups. Correlation analysis between disease duration and SRBF and RNFL thickness was also performed. Results: Mean SRBF was 37.23 ± 2.11 in the SCH group and 38.45±1.20 in the control group. Mean SRBF was significantly lower in the SCH group (p=0.003). Mean Peripapillary RNFL thickness was 98.18±7.77 in the SCH group and 100.07 ± 7.71 in control group. Peripapillary RNFL thickness was not significantly different between groups (p=0.290). There was no significant difference in mean C/D between the groups (p=0.708). Correlation analysis showed a moderate negative correlation between duration of disease diagnosis and SRBF in the SCH group (p<0.001, r=-0.564). There was also a weak to moderate negative correlation between disease duration and RNFL thickness in SCH group (p=0.002, r=-0.489). Conclusions: A reduction in SRBF was observed in patients with subclinical hypothyroidism. Additionally, a negative correlation was identified between disease duration and RNFL thickness. Patients with subclinical hypothyroidism should be monitored for potential retinal vascular disease and the development of normotensive glaucoma.
- MakaleYalnız künye2024Scopus SJRQ2The evaluation of retrobulbar fat tissue in Graves’ orbitopathy with shear-wave ultrasound elastography
Gunes, Irfan Botan; Yilmaz, Hakan; Onal, Eda Demir
Purpose: To evaluate retrobulbar adipose tissue of patients with active and inactive Graves’ orbitopathy (GO) by shear-wave ultrasound elastography (SWE). Methods: Followed-up in our ophthalmology clinic due to GO, 72 eyes of 36 patients and 38 eyes of 19 healthy controls were included in this cross-sectional case–control study. Graves’ patients were divided into two subgroups under clinical activity score (CAS): active Graves’ orbitopathy (AGO) (CAS ≥ 3) and inactive Graves’ orbitopathy (IGO) (CAS < 3). SWE measurement values of retrobulbar adipose tissue of all participants were recorded in meters/second, and the intergroup comparisons were performed. Results: Thirty-four eyes of 17 patients in AGO, 38 eyes of 19 patients in IGO, and 38 eyes of 19 participants in the control group were included in the study. Mean values measured from retrobulbar adipose tissue through SWE were 1.00 ± 0.01 m/sec in AGO, 1.16 ± 0.01 m/sec in IGO, and 0.94 ± 0.01 m/sec in the control groups. Even so, the mean SWE value was significantly higher in the IGO group than in the other groups (p < 0.001). Mean SWE values were significantly higher in the AGO group than in the controls (p = 0.008). In the correlation analysis performed, a significant positive correlation was found between SWE and Hertel exophthalmometer measurement values (p = 0.026, r = 0.212), and thyroid-stimulating hormone receptor antibody (TSHR-Ab) levels (p = 0.018, r = 0.224). Conclusion: We detected SWE values of retrobulbar adipose tissue high in GO, especially in the IGO group. Such a situation, which we associated with the development of fibrosis, may be an indicator of unresponsiveness to immunomodulatory treatments.
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