Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleYalnız künye2026Scopus SJRQ2An investigation into the analyte-dependent fluorescence quenching of BaTiO₃ nanoparticles for the fluorimetric determination of glucose and paracetamol
Cetinkaya, Onur; Altuner, Elif Esra; Yaylali, Figen Varlioglu; Tatli, Havva Nur; Al-Humairi, Safaa Najah Saud
This study investigates the synthesis, characterization, and application of barium titanate nanoparticles (BaTiO₃ NPs) as a fluorimetric sensing platform. Nanocrystalline BaTiO₃ particles, exhibiting quasi-spherical morphology with average diameters evolving from approximately 7 to 9 nm depending on reaction time, were successfully prepared via a room-temperature chemical synthesis route. Comprehensive characterization using techniques such as XRD, SAED, TEM, FTIR, and UV–Vis spectroscopy confirmed the formation of a polycrystalline perovskite structure and elucidated the material's morphological and optical properties. The synthesized BaTiO₃ NPs displayed stable, intrinsic fluorescence, optimally emitting at 467.42 nm upon excitation at ∼402.33 nm in a neutral pH environment (pH 7). This fluorescence was observed to be effectively quenched by multiple analytes, including glucose and paracetamol, establishing a basis for the development of a sensor. Quantitative analysis revealed analyte-dependent quenching efficiencies, with Stern-Volmer studies indicating glucose as the most potent quencher among those kinetically analyzed. The system demonstrated sensitive detection capabilities, achieving low parts-per-million (ppm) limits of detection (LOD) for both glucose (∼1.19 ppm) and paracetamol (∼1.04 ppm). Notably, the linear dynamic response range varied significantly, extending up to ∼1.8 ppm for glucose but reaching at least 3.6 ppm for paracetamol. The demonstrated fluorescence stability, coupled with sensitive and analyte-dependent quenching responses, highlights the potential of these BaTiO₃ nanoparticles as a versatile and robust material for developing future fluorimetric sensors.
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İncele - MakaleYalnız künye2026Scopus SJRQ3Development of Fluorimetric Method for Controlled Drug Release From Vinyl Propionate-co-Maleic Anhydride Polymer Modified With Paracetamol
Memis, Yilmaz; Gunduz, S. Beniz; Altuner, Elif Esra; Tatli, Havva Nur; Ozen, Gurkan; Okudan, Ahmet; Civil, Serife; Dar, Umar Ali
A novel pH-responsive polymeric drug delivery system is developed by covalently binding the active pharmaceutical ingredient paracetamol (PAR) to a synthesized vinyl propionate-co-maleic anhydride (VPR-co-MA) copolymer. The controlled release of PAR from the resulting VPR-co-MA-PAR conjugate was investigated in vitro at various physiological pH values (2.0, 4.5, 7.4, and 9.0) at 37°C over a 6 h-period. A fluorimetric method was utilized to quantify the released PAR, with optimal excitation and emission wavelengths determined to be 330 and 433 nm, respectively. The results demonstrated a distinct pH-dependent release profile. After 6 h, the cumulative drug release was significantly suppressed at acidic gastric pH 2.0 (42.23%), whereas it was substantially higher at neutral and alkaline conditions, reaching 71.29% at pH 7.4 and a maximum of 74.46% at pH 9.0. The pronounced difference in release rates confirms the system's ability to limit premature drug release in the stomach while promoting targeted delivery in the intestinal tract. This VPR-co-MA-PAR conjugate shows significant promise as a carrier for the controlled oral delivery of paracetamol.
- Kitap BölümüYalnız künye2025Scopus SJRQ4Waste Dye Removal with Nanotechnological Methods: Photocatalytic Processes
Altuner, Elif Esra; Tatli, Havva Nur; Aldoori, Bakr; Dar, Umar Ali
This chapter discusses how photocatalytic processes using nanotechnology can counteract the harm done to the environment by waste dyestuffs from industry combining with water, soil, and the environment. When waste dyestuffs from the business mingle with soil and drinking water, they pose a serious hazard to life. For this reason, it is of great importance to remove and neutralize waste dyes with the photocatalyst effect of sunlight and the synergistic effect of nanocatalysts synthesized through nanotechnological means. The photocatalysis process is both environmentally friendly and of great importance to living things. This chapter is also informative about photocatalysis research carried out by nanoparticles under the influence of sunlight.
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