Sancak, Elif İ.; Bilgin, Selen Bozkaya; Tekçe, Neslihan; Sarıhan, Kübra Kavram

The aim of this study is to examine the discoloration in CAD/CAM materials used in dentistry after 4-years of contact with water, which is the environment to which they are most exposed in the oral cavity. Three different A2-colored resin-based CAD/CAM blocks (Cerasmart, Coltene Brilliant Crios and Shofu Block HC) were used in our study. A total of 180 specimens, 60 of each CAD/CAM material, were prepared with a thickness of 2-mm. Then, each material was divided into three different groups based on the polishing systems (Coltene Diatech, Sof-Lex Diamond, Identoflex Diamond Ceramic) applied in accordance with the recommendations of the manufacturing companies (n:20). The discoloration of the materials on a white background and under natural light sources at the beginning and after being stored in distilled water for 4-years were measured with the VITA EasyshadeV spectrophotometer. All the obtained data were examined using the Kolmogorov Smirnov and Shapiro Wilk Normality Test values. After the water aging process, no statistically significant difference was found between the Cerasmart (p=1.51; p>0.05) and Shofu (p=0.95; p>0.05) CAD/CAM material groups using three different polishing systems. A statistically significant difference was found between all polishing system groups of Coltene CAD/ CAM materials (p=0.00). All CAD/CAM materials showed color changes above the ΔE00≤0.8 perceptibility threshold after being aged in distilled water for 4 years. Cerasmart CAD/CAM blocks (Coltene ΔE00=1.33, Sof-lex ΔE00=1.43, Identoflex ΔE00=1.69) showed color changes below the ΔE00≤1.8 acceptability threshold in all groups where different polishing systems were applied, while Coltene (Coltene ΔE00=3.7, Sof-lex ΔE00=3.81, Identoflex ΔE00=4.69) and Shofu (Coltene ΔE00=2.33, Sof-lex ΔE00=1.74, Identoflex ΔE00=1.91) blocks showed color changes above the acceptable threshold value.

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Korun, Zeynep Ece Utkan; Gocmez, Semil Selcen; Furat, Selenay; Sarihan, Kubra Kavram; Eraldemir, Fatma Ceyla; Akpulat, Huseyin Askin; Sahin, Deniz; Yildiz, Sule

Alchemilla vulgaris has traditionally been used to treat gynecologic diseases. The anti-inflammatory and vasorelaxant effects of the extract of A. vulgaris (AVE) have been reported in previous studies. This study aimed to investigate the effects of A. vulgaris on PCOS, one of the most common metabolic disorders in adult women of reproductive age, accompanied by inflammation and vascular endothelial dysfunction, in an experimental animal model. Three groups of prepubertal female Wistar rats were established: PCOS, Control, and PCOS + AVE groups. Subcutaneous dehydroepiandrosterone (DHEA) was administered for 35 days to the PCOS and PCOS + AVE groups. The rats in the PCOS + AVE group were orally administered AVE (50 mg/100 g bw/day) for 35 days. Systemic blood pressure, vascular endothelial function, ovarian morphology, and endocrine biomarker levels were measured at the end of the experiment. TNF-α levels were also evaluated in the thoracic aorta and ovaries. Hormonal imbalances, ovarian morphological changes, and endothelial dysfunction were observed in the PCOS group, which returned to the controls after AVE treatment. Furthermore, AVE attenuated the aortic and ovarian levels of TNF-α in the PCOS group. Our study suggests that AVE may have beneficial effects in the treatment of PCOS due to its anti-inflammatory and vasculoprotective properties.

AtıfScopus3·WoS1

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