Sürdürülebilir Kalkınma Amaçları

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• MakaleYalnız künye2026/r/kostu/10974
  Suppressing Liver Cancer via the VEGFR1 Receptor using De novo Ellagic Acid Derivatives and Co-drugs: Comprehensive In silico Biochemistry Research with ADMET, RMSD, Molecular Docking, and Molecular Dynamics Simulations

  Agar, S; Acar, E; Aldemir, O; Gokoluk, E; Issa, G; Bogdanov, J

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  İncele
• MakaleAçık Erişim2026/r/kostu/10860
  In silico biochemical de novo drug design of valproic acid derivatives to suppress cancerous dna: comprehensive molecular docking, molecular dynamics, 1 h nmr, adme

  Acar, Esra; Issa, Ghassan; Agar, Soykan; Gökoluk, Erkan; Giglou, Erfan Akhavan; Şimşek, Dilruba

  Objective: This comprehensive in silico computational and theoretical biochemistry/organic chemistry research study covers the inhibition methodologies of 1-BNA, which is an essential template for cancer- suppressing research. By disrupting the minor groove domain binding site of the DNA template 1-BNA dodecamer, three de novo drug candidate molecules via derivatization of anti-epileptic valproic acid (VPA) drug were designed. Methods: Calf thymus DNA (ct-DNA) sequence d(CGCGAATTCGCG)2 dodecamer (PDB ID: 1BNA) was obtained from the Protein Data Bank to study. Molecular docking simulations, the most updated docking programs of AutoDock Vina and PyRx were utilized. Molecular dynamics (MD) simulations and Absorption, distribution, metabolism and excretion (ADME) analyses were employed by Schrödinger’s Desmond software. Results: Thorough in silico results of three new derivatized analogues of VPA showed that chloro-derivatized analogue with its -9.6 kcal/mol docking score and 297.2 µM inhibition constant (IC) has a much better indication in the suppression where isopropyl and fluoro derivatized analogues possess -9.1 kcal/mol docking score with 483.8 µM IC and - 8.3 kcal/mol docking score with 896.2 µM IC respectively compared to the results of pristine VPA’s -8.2 kcal/mol docking score with 863.6 µM IC. Along with the detailed ADME results, isopropyl and chloro- derivatized ligands prove their worth of being a new drug candidate. Conclusion: All results proved that the de novo derivatives of VPA illustrate better docking scores (better suppression) along with better ICs and oral absorption percentage values, meaning that the analogues possess better indications compared to pristine VPA toward the suppression of cancerous cell template DNA.

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• MakaleAçık Erişim2026/r/kostu/10836
  Investigation of pathogenic contamination on toy materials through microbiological and structural characterization approaches

  Acar, Esra; Issa, Ghassan; Aksu, Harun; Altuner, Elif Esra; Aldemir, Ozan

  Objective: Toys in kindergartens are frequently exposed to environmental contaminants and hand contact, making them potential reservoirs for pathogenic microorganisms. Children, with developing immune systems, are particularly vulnerable to infections. This study aimed to detect Escherichia coli, Staphylococcus aureus, and coliform bacteria on toys and to characterize toy materials using FTIR, XRD, and SEM. Methods: Swab samples were collected from toy surfaces under aseptic conditions and transported under cold-chain conditions. Samples were homogenized in buffered peptone water and serially diluted. Coliforms were detected on VRB and BGBLB media, E. coli on TBX medium, and S. aureus on Baird-Parker Agar with Egg Yolk Tellurite. Identification was confirmed via Gram staining, catalase, DNase, hemolysis, and carbohydrate fermentation tests. FTIR assessed functional groups, XRD examined crystalline structures, and SEM observed surface morphology related to microbial adhesion. Results: Bacteriological analysis showed Staphylococcus spp. (35.33%), S. aureus (5%), E. coli (1%), and coliforms (3.66%). FTIR revealed diverse polymeric structures, XRD showed varying crystallinity, and SEM indicated heterogeneous surface roughness and irregular microstructures facilitating bacterial adhesion. Conclusion: Combining microbiological analyses with FTIR, XRD, and SEM provides a comprehensive method for assessing contamination risks. Kindergarten toys can harbor potentially pathogenic microorganisms, and the structural characteristics of toy materials significantly influence microbial persistence.

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  İncele
• Derleme MakaleYalnız künye2026Scopus SJRQ2/r/kostu/10672
  Indomethacin as a Multi-target Anticancer Agent via Transmembrane Receptor-mediated Tumor Suppression: The Need for de novo Drug Derivatization

  Ozturk, Ebru; Issa, Ghassan; Agar, Soykan

  Introduction: Indomethacin, a non-steroidal anti-inflammatory drug (NSAID), has attracted increasing attention for its promising anticancer properties, particularly regarding its crucial effect on transmembrane receptor-mediated signal transduction in different cancers. Besides COX-inhibitory activities, other mechanisms underlying indomethacin's potential as an anticancer agent are being explored, including those related to the mediation of prostaglandin signaling through transmembrane receptors in solid tumors. Methods: In this mini-review, we summarize available information about modulation of transmembrane receptor signaling by indomethacin, including death receptors, EP receptors, receptor tyrosine kinases (RTKs), chemokine receptors, cannabinoid receptors, ACE2, P2X7, IP, and FZD/LRP5/6 receptors associated with Wnt pathways. Results: The presented data indicate that indomethacin may inhibit PGE₂-induced EP signaling, affect EGFR/FGFR and CXCR3 signaling pathways, increase death receptor-mediated apoptosis, and influence various types of receptor cross-talk involved in proliferation, angiogenesis, immune evasion, invasion, and metastasis. However, the most consistent results were obtained in colorectal cancer cells, while the role of indomethacin in breast, ovarian, and prostate cancers appears to be more contextual and receptor-profile dependent. Discussion: Overall, our review suggests that indomethacin functions mainly as a receptor signaling modulator rather than a selective receptor antagonist. The potential clinical application of indomethacin for cancer treatment is hindered by its poor selectivity towards COX enzymes, toxicity, and lack of specificity. Conclusion: Despite the possibility of using indomethacin as a template structure for creating more selective drugs, it seems that indomethacin cannot serve as a drug for anticancer therapy alone. This conclusion specifically positions parent indomethacin as a chemically modifiable scaffold for rational derivative development rather than as a final therapeutic endpoint. 2026, Bentham Science Publishers

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  İncele
• Derleme MakaleAçık Erişim2026Scopus SJRQ2/r/kostu/10455
  Sustainable Ammonia Production, Advances in Electrochemical, Photoelectrochemical, and Photocatalytic Technologies for Green Energy

  Shahin, Musarat; Mohsin, Abdul Haseeb; Bibi, Aiman; Ahmad, Ihtisham; Altuner, Elif Esra; Aldemir, Ozan; Durmusoglu, Senol; Yilancilar, Mehmet Sabit; Tanriverdi, Yavuz; Acar, Esra

  Substantial advances have been made since the 1970s in reducing the environmental impacts of ammonia production. Renewable-driven electrochemical synthesis offers a promising pathway to decarbonize ammonia production. This review examines an integrated route in which hydrogen is generated photoelectrochemically under concentrated solar irradiation and subsequently used in electrochemical ammonia synthesis. Photoelectrochemical cells are fabricated by electrostatically depositing photosensitive particles onto cathodes to enhance light-driven hydrogen production. Hydrogen production rates and ammonia yield depend strongly on temperature and electrolyte composition. The synthesized hydrogen is fed into a molten salt electrochemical reactor that operates at atmospheric pressure and receives nitrogen from a dedicated supply. This combined solar–electrochemical approach can produce low-carbon ammonia with improved safety and reduced environmental impact, offering a scalable alternative to conventional processes.

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  AtıfScopus1·OpenAlex1

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• MakaleYalnız künye2026Scopus SJRQ3/r/kostu/10290
  Synthesis of β-Lactam Conjugates of Thiadiazine Thiones as a New Class of Anti-Nociceptive Agents

  Mohsin, Abdul Haseeb; Torlak, Yasemin; Altuner, Elif Esra; Aldemir, Ozan; Khan, Rasool; Issa, Ghassan; Zafar, Salman; Bibi, Aiman; Khan, Misbah Rafiq; Khan, Huma

  A series of newly synthesized β-lactam conjugates of thiadiazine-2-thiones (TDZ-2T) were prepared by reacting various primary amines with carbon disulfide and potassium hydroxide, followed by the addition of formaldehyde and β-lactam antibiotics, including cefaclor and cefadroxil, in phosphate buffer. The synthesized substances were evaluated for their in vitro antimicrobial activity against P. aeruginosa and E. coli. All the substances exhibited activity against each forms of bacterial types, with 1e, 1f, 1g, 2a, and 2b showing the most significant activity. Additionally, the anti-nociceptive impact of the prepared substances was analyzed by the hot plate technique. Substances 1a, 1b, 1d, 1f, 1g, and 2a demonstrated notable activity at dosages of 80 mg/kg, as evidenced by a significant enhancement during the lag phase. Intact binding studies of the synthesized substance were also performed and showed a good binding interaction with the binding site of the in silico cyclooxygenase-2 (COX) enzyme.

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  AtıfScopus1·OpenAlex1

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• MakaleYalnız künye2026Scopus SJRQ3/r/kostu/10267
  Biogenic Silver Nanoparticles from Citrus reticulata Peels for Ultrasensitive Electrochemical Sensing of 4-Aminobenzenesulfonamide

  Dar, Umar Ali; Altuner, Elif Esra; Akocak, Suleyman; Issa, Ghassan; Ozalp, Veli Cengiz

  Increasing utilization of sulfonamide derivatives as antibacterial agents has created serious challenges in terms of environmental pollution and antimicrobial resistance. In this respect, there is a compelling need for a highly sensitive and selective analytical tool for detecting such antibiotics in trace concentrations. This work represents a green strategy for developing an electrochemical biosensor for the determination of 4-aminobenzenesulfonamide based on bio-functionalized silver nanoparticles (Ag NPs) prepared from peel extract of Citrus reticulata fruit. The phytochemicals present in the peel extracts played a dual role of reduction and stabilization during the synthesis of Ag NPs. Synthesized NPs were well characterized through scanning electron microscopy (SEM), X-ray diffraction (XRD), Ultraviolet spectroscopy (UV–Vis), and Fourier infrared spectroscopy (FTIR) techniques. The Ag NPs showed considerable improvement in electrocatalysis in comparison to the bare glassy carbon electrode. The fabricated sensor gave an excellent linear calibration curve with a high value of R2 (=0.999), along with a low limit of detection (LOD = 0.65 µM) and limit of quantification (LOQ = 2.1 µM).

  İncele
• MakaleAçık Erişim2025Scopus SJRQ3/r/kostu/10663
  Investigation of quaternary ammonium compound resistance in Staphylococcus aureus strains isolated from several foods and food production facilities

  Bayrakal, G.M.; Aydin, A.; Issa, G.; Dumen, E.; Sudagidan, M.

  Quaternary ammonium compounds (QACs) are the most significant disinfectants utilised to control the contamination of Staphylococcus aureus in food establishments. S. aureus is a significant pathogen that carries genes responsible for resistance to QACs, which pose a risk to public health and food safety. The objective of the study was to investigate the prevalence of QAC genes (qacA/B, qacC, qacG, qacH, qacJ, and smr) and benzalkonium minimal inhibitory concentration (MIC) values in S. aureus strains isolated from food products and food production facilities (n = 200). The analysis results indicated that the qacC gene was the most frequently detected, with a prevalence of 12%. The qacA/B, qacG, qacH, qacJ, and smr genes were identified at frequencies of 2%, 3%, 1%, 4.5%, and 5%, respectively. The highest MIC level was identified in the surface sample, which carried the qacG gene, at a concentration of 6.25 μg mL-1. The study's results highlight the potential risks associated with disinfectant resistance in food establishments. To prevent the transfer of disinfectant resistance genes, which have become a global risk, it is imperative that the rules of disinfectant usage are observed rigorously and that scientific research in this field is diversified.

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  AtıfScopus6·WoS6·OpenAlex6

  İncele
• Kitap BölümüYalnız künye2025/r/kostu/10359
  Role and scope of porphyrin composites in biotechnology

  Altuner, Elif Esra; Issa, Ghassan; Sen, Fatih; Dar, Umar Ali

  In this chapter, the roles of porphyrins and their derivatives in daily life, their application areas, and their importance in medical imaging for target regions and cell detection are discussed. Porphyrins are structures that can adapt to biotechnological studies due to their structures. Therefore, it is of great importance in biotechnology, especially in medical imaging. Detection of the defective region in magnetic resonance imaging, determination of the target by moving the porphyrins using rays in the photoacoustic region, or the emergence of a colored label with the fluorescence technique are the most important advantages of porphyrins. Therefore, the importance of porphyrins in today's technology, especially in medical imaging, will support future technological studies.

  İncele
• MakaleAçık Erişim2025Scopus SJRQ3/r/kostu/10269
  Detection of airborne bacteria and fungi in meat plants

  Altunatmaz, Sandikci; Aydin, A.; Issa, G.; Aksu, F.; Dulger Altiner, D.; Aksu, H.

  The present work aimed to determine the total airborne bacterial and fungal loads in three meat plants, identify the isolated fungi, and determine the fungal diversity. The air samples were collected from 23 different sampling points within the meat plants using two different techniques: the Petri dish exposure (sedimentation) method and the impaction method (using Mas-100 Eco Air Sampler device). Using the sedimentation method, the total mesophilic aerobic bacterial and fungal counts were found to be 1 - 180 CFU/Petri-15 min (mean 48.49 CFU/Petri-15 min) and 1 - 105 CFU/Petri (mean 19.845 CFU/Petri), respectively. Using the impaction method, the counts ranged from 8 to 385 CFU/m³ (mean 112.77 CFU/m³) for bacteria, and from 2 to 320 CFU/m³ (mean 57.45 CFU/m³) for fungi. A total of 76 isolates were obtained. The most commonly isolated fungal species were Mucor spp. (n = 28, 36.84%), Rhizopus spp. (n = 22, 28.94%), and Penicillium spp. (n = 18, 23.68%). Mucor racemosus (n = 20) and Rhizopus oryzae (n = 14) were the most common species. Additionally, Aspergillus spp. (n = 3, 3.94%), Geotrichum spp. (n = 3, 3.94%), Syncephalostrum sp. (n = 1, 1.31%), and Wallemia sp. (n = 1, 1.31%) were detected. The present work demonstrated that fungi, which could be pathogens and spoilers, may be present in the ambient air of meat plants. Therefore, maintaining air hygiene in meat plants, from economic and health perspectives, is essential.

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  AtıfScopus1·WoS1

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