Sürdürülebilir Kalkınma Amaçları

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• MakaleAçık Erişim2025Scopus SJRQ3/r/kostu/10780
  Manufacture, characterization and in vitro drug release studies of chitosan-PVA-MNPs hydrogel essenced drug delivery system for anticancer drug quercetin

  Özsoy, Munteha; Heidarnejad, Mahsa

  In the current study, chitosan (CS) and polyvinyl alcohol (PVA) essenced hydrogels were produced using the freeze-thaw method without toxic cross-linking agents. Magnetic nanoparticles (MNPs) and quercetin (QC) were added to the system after synthesizing the hydrogel and the samples were freeze-dried using a lyophilizer. The prepared samples were used in in vitro drug release studies. QC, known as a natural polyphenol, is a promising candidate to support cancer treatment with its antioxidant effects. However, the hydrogels containing Fe3O4 nanoparticles exhibit high porosity and encapsulation efficiency, making them a convenient carrier for drug loading and controlled release. The QC was encapsulated in the synthesized CS-PVA-MNPs. Morphological changes of the prepared hydrogels were visualized using scanning electron microscopy (SEM). The molecular structure of the synthesized samples was determined using fourier transform infrared spectroscopy (FTIR), while their thermal stability was evaluated through thermogravimetric analysis (TGA). The encapsulation efficiency (EE) and drug loading efficiency (DLE) of QC in hydrogels including Fe3O4 MNPs were determined as 93.40% and 65.58%, respectively. In vitro release profiles of QC at pH 5 and pH 7.4 demonstrated the effectiveness of the hydrogel. These results indicate that CS-PVA-MNPs-QC is a convenient carrier for the intended drug delivery and reveal the potential of QC as a drug versus cancer cells.

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  AtıfWoS2·OpenAlex2

  İncele
• MakaleAçık Erişim2024Scopus SJRQ3/r/kostu/10561
  Inhibition of pancreatic cancer via LPAR4 receptor with a de novo drug complex design using theoretical organic chemistry: Comprehensive molecular docking, molecular dynamics

  Agar, Soykan; Arasan, Yaren; Akkurt, Barbaros; Ulukaya, Engin

  The present work relates to a de novo organic chemistry involved drug design and repurposing discovery of a Quercetin and Ascorbic Acid complex formation with the IUPAC nomenclature of ‘’3-((2S)-2-(3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl)-2-hydroxyethoxy)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one’’ to suppress pancreatic cancer via the inhibition of LPAR4 receptor. This was achieved with molecular docking and molecular dynamics studies and found that Ascorbic Acid is docking manoeuvre assistant for Quercetin to form Hydrogen bonds and Covalent bonds to shut down LPAR4 receptor with excellent inhibition constant. This study may very well lead to further in vitro organic synthesis, characterization and cell line results and in vivo/ex ovo animal testing for etherical bound Quercetin and Ascorbic Acid complex.

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  AtıfScopus1·OpenAlex3·TR Dizin3

  İncele
• MakaleAçık Erişim2022Scopus SJRQ3/r/kostu/10735
  The Anatomical Features of Endemic Hypericum spectabile Jaub. & Spach from Türkiye

  Altinbaşak, Onur; Kültür, Şükran

  Hypericum L. genus is used as a soothing, antiseptic and antispasmodic agent under the name of “kantaron, kılıçotu, kanotu, yaraotu, kuzukıran, koyunkıran, binbirdelik” otu in Turkish folk medicine. This study reveals the anatomical features of H. spectabile belonging to Drosanthe sections of Hypericum L. genus. The stem, leaf and root anatomical features of the plant is investigated for the first time in this study. In the stem sections of stem there are two rows of epidermal tissue. The epidermis is surrounded by a thick cuticle layer. Just below the cortex, parenchyma covers a large area. Phloem has A type secretory secretory cells. Xylem is composed of sclerenchymatic cells and tracheary elements in vascular bundles. The pith is composed of parenchymatic cells. In the section of the root there are four-five rows of periderm. Below this tissue there is cortex parenchyma with intercellular spaces. Inward, there are phloem and xylem tissues. The pith consists of parenchymatic cells. Leaf mesophyll layer has palisade parenchyma on both surfaces. Leaf is equifacial. Collenchyma tissue is in four-five rows on the upper and lower surfaces of the middle vein. The leaf is amphistomatic. Stomata belong to anisocytic types.

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