Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Adas, Gokhan Tolga(1)
- Akgul, Ozer(1)
- Bošković, Jelena(1)
- Caliskan, Reyhan(1)
- Cetinkaya, Onur(1)
- Coskun, Goknil Pelin(1)
- Demirayak, Seref(1)
- Demirturk Kocasarac, Husniye(1)
- Dobričić, Vladimir(1)
- Ercan, Bahadir(1)
- Helvacioglu-Yigit, Dilek(1)
- Jenczyk, Jacek(1)
- Jung, Jarosław(1)
- Jurga, Stefan(1)
- Kozanecki, Marcin(1)
- Kursun-Cakmak, Sebnem(1)
- Matyjaszewski, Krzysztof(1)
- Nowaczyk, Grzegorz(1)
- Omac Sonmez, Mehtap(1)
- Oner, Yasar Ali(1)
- Ozhan, Yagmur(1)
- Peker, Kivanc Derya(1)
- Pietrasik, Joanna(1)
- Polat Sari, Silva(1)
- Reis, Rengin(1)
- Sahin, Zafer(1)
- Sapmaz, Burcu(1)
- Seki, Umut(1)
- Singh, Maharaj(1)
- Sipahi, Hande(1)
- Soylu, Aliye(1)
- Udovytska, Ruslana(1)
- Ulański, Jacek(1)
- Wypych-Puszkarz, Aleksandra(1)
- Yan, Jiajun(1)
- Yuksel Mayda, Pelin(1)
Yayınlar
- MakaleAçık Erişim2023Scopus SJRQ1Discovery of Novel Thiophene/Hydrazones: In Vitro and In Silico Studies against Pancreatic Cancer
Coskun, Goknil Pelin; Ozhan, Yagmur; Dobričić, Vladimir; Bošković, Jelena; Reis, Rengin; Sipahi, Hande; Sahin, Zafer; Demirayak, Seref
Cancer is the disease with the highest mortality. Drug studies contribute to promising treatments; however there is an urgent need for selective drug candidates. Pancreatic cancer is difficult to treat and the cancer progresses rapidly. Unfortunately, current treatments are ineffective. In this study, ten new diarylthiophene-2-carbohydrazide derivatives were synthesized and evaluated for their pharmacological activity. The 2D and 3D anticancer activity studies suggested the compounds 7a, 7d, and 7f were promising. Among these, 7f (4.86 µM) showed the best 2D inhibitory activity against PaCa-2 cells. Compounds 7a, 7d and 7f were also tested for their cytotoxic effects on healthy cell line but only compound 7d showed selectivity. Compounds 7a, 7d, and 7f showed the best 3D cell line inhibitory effect according to spheroid diameters. The compounds were screened for their COX-2 and 5-LOX inhibitory activity. For COX-2, the best IC50 value was observed for 7c (10.13 µM) and all compounds showed significantly lower inhibition compared to standard. In the 5-LOX inhibition study, compounds 7a (3.78 µM), 7c (2.60 µM), 7e (3.3 µM), and 7f (2.94 µM) demonstrated influential activity compared to standard. Regarding molecular docking studies, binding mode of compounds 7c, 7e, and 7f to the 5-LOX enzyme were non-redox or redox types, but not the iron-binding type. As dual inhibitors of 5-LOX and pancreatic cancer cell line, 7a and 7f were identified as the most promising compounds.
AtıfScopus7WoS7OpenAlex6
İncele - MakaleAçık Erişim2022Scopus SJRQ1Molecular Dynamics and Structure of Poly(Methyl Methacrylate) Chains Grafted from Barium Titanate Nanoparticles
Wypych-Puszkarz, Aleksandra; Cetinkaya, Onur; Yan, Jiajun; Udovytska, Ruslana; Jung, Jarosław; Jenczyk, Jacek; Nowaczyk, Grzegorz; Jurga, Stefan; Ulański, Jacek; Matyjaszewski, Krzysztof
Core−shell nanocomposites comprising barium titanate, BaTiO3 (BTO), and poly(methyl methacrylate) (PMMA) chains grafted from its surface with varied grafting densities were prepared. BTO nanocrystals are high-k inorganic materials, and the obtained nanocomposites exhibit enhanced dielectric permittivity, as compared to neat PMMA, and a relatively low level of loss tangent in a wide range of frequencies. The impact of the molecular dynamics, structure, and interactions of the BTO surface on the polymer chains was investigated. The nanocomposites were characterized by broadband dielectric and vibrational spectroscopies (IR and Raman), transmission electron microscopy, differential scanning calorimetry, and nuclear magnetic resonance. The presence of ceramic nanoparticles in core–shell composites slowed down the segmental dynamic of PMMA chains, increased glass transition temperature, and concurrently increased the thermal stability of the organic part. It was also evidenced that, in addition to segmental dynamics, local β relaxation was affected. The grafting density influenced the self-organization and interactions within the PMMA phase, affecting the organization on a smaller size scale of polymeric chains. This was explained by the interaction of the exposed surface of nanoparticles with polymer chains.
AtıfScopus10WoS9OpenAlex11İncele - MakaleAçık Erişim2022Scopus SJRQ2Comparative Evaluation of Artifacts Originated by Four Different Post Materials Using Different CBCT Settings
Helvacioglu-Yigit, Dilek; Seki, Umut; Kursun-Cakmak, Sebnem; Demirturk Kocasarac, Husniye; Singh, Maharaj
The aim of this study was to evaluate whether cone beam computed tomography (CBCT) images in the presence of four different post materials, obtained from different kVps with varying resolutions and varying metal artifact reduction (MAR) algorithms, differed in artifact estimation, and to compare tooth regions in terms of artifact value. Materials and Methods: Forty premolar teeth were used in this study. Root canals were treated, and teeth were randomly distributed into four subgroups (n = 10) for the preparation of post materials: titanium, gold (Nordin), quartz fiber (Bisco DT Light), and glass fiber (Rely X). The CBCT images were taken with two different kVps, three different metal artifact reduction (MAR) algorithm options, and two different resolutions. For each protocol, the effective dose was calculated according to the dose area production (DAP) value. The standard analysis of variance technique and the Tukey multiple comparison adjustment method were used to assess interactions among material types, kVp, MAR, and voxel settings. Results: More artifacts were found in the middle third than in the cervical third (p < 0.05). The mean value of artifacts was highest for gold (Nordin), 90 kVp, no MAR, and 100 voxel size. Glass or quartz fiber posts at low resolution, with high MAR and 96 kVp, originated fewer artifacts. Moreover, the use of 90 and 96 kVp with 200 voxel size and high MAR provided the least amount of radiation. Conclusion: The best setting for radiographic follow-up of post materials on the Planmeca ProMax is 96 kVp with low resolution and high MAR; this setting produced one of the lowest effective doses. Clinical Significance: This study estimated the best scanning protocol by lowering the effective dose to a minimum level according to the “as low as reasonably achievable” principle, as well as assessing the tooth region and the post material generating the fewest artifacts, in order to prevent image interpretation challenges such as false-positive and false-negative results stemming from the deterioration of the visibility of the root canal due to perforation, fractures, and voids in the root canal region.
AtıfScopus7WoS4OpenAlex5İncele - MakaleAçık Erişim2022Scopus SJRQ2New CagL Amino Acid Polymorphism Patterns of Helicobacter pylori in Peptic Ulcer and Non-Ulcer Dyspepsia
Caliskan, Reyhan; Polat Sari, Silva; Ercan, Bahadir; Peker, Kivanc Derya; Omac Sonmez, Mehtap; Akgul, Ozer; Sapmaz, Burcu; Soylu, Aliye; Adas, Gokhan Tolga; Oner, Yasar Ali
Background and Objectives: Helicobacter pylori infection is associated with chronic gastritis, ulcers, and gastric cancer. The H. pylori Type 4 secretion system (T4SS) translocates the CagA protein into host cells and plays an essential role in initiating gastric carcinogenesis. The CagL protein is a component of the T4SS. CagL amino acid polymorphisms are correlated with clinical outcomes. We aimed to study the association between CagL amino acid polymorphisms and peptic ulcer disease (PUD) and non-ulcer dyspepsia (NUD). Materials and Methods: A total of 99 patients (PUD, 46; NUD, 53) were enrolled and screened for H. pylori by qPCR from antrum biopsy samples. The amino acid polymorphisms of CagL were analyzed using DNA sequencing, followed by the MAFFT sequence alignment program to match the amino acid sequences. Results: Antrum biopsy samples from 70 out of 99 (70.7%) patients were found to be H. pylori DNA-positive. A positive band for cagL was detected in 42 out of 70 samples (PUD, 23; NUD, 19), and following this, these 42 samples were sequenced. In total, 27 different polymorphisms were determined. We determined three CagL amino acid polymorphism combinations, which were determined to be associated with PUD and NUD. Pattern 1 (K35/N122/V134/T175/R194/E210) was only detected in PUD patient samples and was related to a 1.35-fold risk (p = 0.02). Patterns 2 (V41/I134) and 3 (V41/K122/A171/I174) were found only in NUD patient samples and were linked to a 1.26-fold increased risk (p = 0.03). Conclusions: We observed three new patterns associated with PUD and NUD. Pattern 1 is related to PUD, and the other two patterns (Patterns 2 and 3) are related to NUD. The patterns that we identified include the remote polymorphisms of the CagL protein, which is a new approach. These patterns may help to understand the course of H. pylori infection.
AtıfScopus1WoS1OpenAlex3İncele - DergiMolecules
- DergiTomography
- DergiMedicina (Lithuania)
- DergiPharmaceutics