Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleAçık Erişim2026Determination of Antioxidant Activity, Antimicrobial Effect and Fatty Acid Composition of Red Pine Bark (Pinus brutia Ten., Turkish Pine) Extracts
Tekeli, Yener; Muhammet, Sinan Mithat; Çevrimli, Bekir Sıtkı; Altuner, Elif Esra; Tekeli, Tuba; Hacıabdullahoğlu, Adnan
In this study, the antioxidant activity, antimicrobial effect, and fatty acid composition of the bark of the Turkish Pine (Pinus brutia Ten.) grown in Burdur Province (Türkiye) were investigated. Red pine bark extracts were analyzed using the Folin-Ciocalteau method for total phenolic content, the DPPH test for free radical scavenging activity, the FRAP test for reduction power, and the carotene-linoleic acid test to determine antioxidant activity. Red pine bark was found to have a significant antioxidant effect. The total phenomenon, expressed as gallic acid, was found to be 287.31 mg GAE/100 g, while the free radical inhibition rate was found to be 93.94%. The results were compared with the standard antioxidants BHA and BHT. The antimicrobial activity of the chloroform, methanol, and ethyl acetate extracts of red pine bark was examined against four bacteria strains using the microdilution method, and their fatty acid compositions were determined using a GC-FID device. Although it showed no activity against Staphylococcus aureus, it produced remarkable results against Bacillus cereus and Escherichia coli in particular. Therefore, it was found to have a good antibacteria effect and an important fatty acid profile for industry with long-chain (24-carbon) saturated and long-chain unsaturated fatty acids. While the SFA value was high (89.23%), C24:0 (lignoceric acid) was the predominant fatty acid with a proportion of 51.5%, followed by C22:0 at 28.38%.
- MakaleAçık Erişim2026Investigation of pathogenic contamination on toy materials through microbiological and structural characterization approaches
Acar, Esra; Issa, Ghassan; Aksu, Harun; Altuner, Elif Esra; Aldemir, Ozan
Objective: Toys in kindergartens are frequently exposed to environmental contaminants and hand contact, making them potential reservoirs for pathogenic microorganisms. Children, with developing immune systems, are particularly vulnerable to infections. This study aimed to detect Escherichia coli, Staphylococcus aureus, and coliform bacteria on toys and to characterize toy materials using FTIR, XRD, and SEM. Methods: Swab samples were collected from toy surfaces under aseptic conditions and transported under cold-chain conditions. Samples were homogenized in buffered peptone water and serially diluted. Coliforms were detected on VRB and BGBLB media, E. coli on TBX medium, and S. aureus on Baird-Parker Agar with Egg Yolk Tellurite. Identification was confirmed via Gram staining, catalase, DNase, hemolysis, and carbohydrate fermentation tests. FTIR assessed functional groups, XRD examined crystalline structures, and SEM observed surface morphology related to microbial adhesion. Results: Bacteriological analysis showed Staphylococcus spp. (35.33%), S. aureus (5%), E. coli (1%), and coliforms (3.66%). FTIR revealed diverse polymeric structures, XRD showed varying crystallinity, and SEM indicated heterogeneous surface roughness and irregular microstructures facilitating bacterial adhesion. Conclusion: Combining microbiological analyses with FTIR, XRD, and SEM provides a comprehensive method for assessing contamination risks. Kindergarten toys can harbor potentially pathogenic microorganisms, and the structural characteristics of toy materials significantly influence microbial persistence.
- Kitap BölümüYalnız künye2026Scopus SJRQ4Nanometarial-Based Sensors: Transforming Real-Time Monitoring in Biomedical Applications
Altuner, Elif Esra; Torlak, Yasemin
Nanomaterial-based sensors are radically changing real-time monitoring technologies in biomedical applications. Offering higher sensitivity, selectivity, and fast response time compared to traditional sensors, these sensors have great potential for detecting various biomarkers and continuous health monitoring. Nanomaterials such as graphene, fullerenes, and metal oxide nanoparticles play an important role in disease diagnosis, monitoring of treatment processes, and personalized medicine applications by improving the performance of biosensors. These sensors, which are used primarily in detecting blood sugar, cancer markers, infection indicators, and biomolecules associated with neurodegenerative diseases, increase patient comfort by offering non-invasive and minimally invasive methods. Nanomaterial-based sensors, which can be integrated into wearable and portable devices, provide revolutionary innovations in the healthcare sector by expanding the possibilities of remote health monitoring and early diagnosis.
- Derleme MakaleYalnız künye2026Scopus SJRQ1The role of green chemistry in the transformation of agro-industrial wastes for health and environment: a review
Garg, Manoj Chandra; Kumari, Sheetal; Nguyen, Minh-Ky; Daudu, Basil Osayin; Thapa, Sanskriti; Gupta, Juhi; Kumar, Manish; Altuner, Elif Esra; Yadav, Akhilesh Kumar; Anaiye, Esther Besty
Green chemistry is defined as a set of principles that reduce or prevent the use or generation of hazardous substances during the design, production, and utilization of chemical products. The vision of such a paradigm shift in the chemical sciences is that the concept of being green is directly introduced to the molecular design process and is centered on atom economy and the prevention of waste. This review examines the principles of green chemistry in relation to agro-industrial waste valorization, with specific reference to the ecological and economic conditions of India, where approximately 350 million metric tons of annual agro-residues have become a source of serious environmental management issues, such as greenhouse gas emissions through open burning, leachate waste generation through landfills, and effects on the health of the population through poor disposal practices. The analysis summarizes the latest developments in nanotechnology-based catalytic systems, new solvent platforms (ionic liquids, deep eutectic solvents, and supercritical fluids), and integrated biorefineries, and critically reviews the scalability limitations and commercial feasibility. It also discusses more recent developments, such as systems based on nanotechnology, catalyst transformations (homogeneous, heterogeneous, and biocatalysts), and the creation of alternative solvents, such as ionic liquids, deep eutectic solvents, and supercritical fluids. The virtues of agri-industrial residues and biomass-based feeds are given particular attention in terms of their role in models of the circular economy and the generation of value-added chemicals, fuels, and materials. By illustrating how green chemistry can minimize the environmental footprint of traditional processes and create safer and more economically viable alternatives, this review makes it clear why green chemistry has become a revolution in the field of industrial practice. Lastly, the paper addresses contemporary issues of scalability, economic competitiveness, and regulatory integration and outlines opportunities that will make green chemistry the foundation of sustainable, resource-efficient, and environmentally responsible chemical companies.
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İncele - MakaleAçık Erişim2026Scopus SJRQ3Synthesis, Characterization, and Anticancer Activity of Pyrene-Based Schiff Base Ligands and Their Transition Metal Complexes
Ay, Hilal; Sahin, Ozlem; Karakurt, Serdar; Altuner, Elif Esra; Aldemir, Ozan; Acar, Esra; Sahin, Mustafa
This study details the synthesis, characterization of unsymmetrical Schiff base ligand and their metal complexes Ni(II), Zn(II), Pb(II), and Cu(II) for anticancer assessment. These ligands were prepared by condensation reaction between 1,2-phenylenediamine in combinations with 2,5-dihydroxybenzaldehyde, 1-pyrenecarboxaldehyde, and 3-hydroxybenzaldehyde, producing distinctive molecular structures. Comprehensive analysis of their structural and electronic properties were conducted using elemental analysis, UV–Vis, FT-IR. 1H NMR, 13C-NMR spectroscopy, supplemented by magnetic moment measurements and fluorescence studies. The biological efficacy of the Schiff base derivatives was tested against DLD1 colon cancer cells, with cellular imaging employed to observe their effects. Notably, cytotoxicity assays showed IC50 values of 38.4 µM for ligand L1′and 7.3 µM for ligand L2′, indicating strong activity against colorectal carcinoma (CRC) cells. Significantly, both compounds exhibited minimal toxicity toward healthy epithelial cells (IC50 > 200 µM), demonstrating their selective anticancer potential.
- MakaleYalnız künye2026Scopus SJRQ2An investigation into the analyte-dependent fluorescence quenching of BaTiO₃ nanoparticles for the fluorimetric determination of glucose and paracetamol
Cetinkaya, Onur; Altuner, Elif Esra; Yaylali, Figen Varlioglu; Tatli, Havva Nur; Al-Humairi, Safaa Najah Saud
This study investigates the synthesis, characterization, and application of barium titanate nanoparticles (BaTiO₃ NPs) as a fluorimetric sensing platform. Nanocrystalline BaTiO₃ particles, exhibiting quasi-spherical morphology with average diameters evolving from approximately 7 to 9 nm depending on reaction time, were successfully prepared via a room-temperature chemical synthesis route. Comprehensive characterization using techniques such as XRD, SAED, TEM, FTIR, and UV–Vis spectroscopy confirmed the formation of a polycrystalline perovskite structure and elucidated the material's morphological and optical properties. The synthesized BaTiO₃ NPs displayed stable, intrinsic fluorescence, optimally emitting at 467.42 nm upon excitation at ∼402.33 nm in a neutral pH environment (pH 7). This fluorescence was observed to be effectively quenched by multiple analytes, including glucose and paracetamol, establishing a basis for the development of a sensor. Quantitative analysis revealed analyte-dependent quenching efficiencies, with Stern-Volmer studies indicating glucose as the most potent quencher among those kinetically analyzed. The system demonstrated sensitive detection capabilities, achieving low parts-per-million (ppm) limits of detection (LOD) for both glucose (∼1.19 ppm) and paracetamol (∼1.04 ppm). Notably, the linear dynamic response range varied significantly, extending up to ∼1.8 ppm for glucose but reaching at least 3.6 ppm for paracetamol. The demonstrated fluorescence stability, coupled with sensitive and analyte-dependent quenching responses, highlights the potential of these BaTiO₃ nanoparticles as a versatile and robust material for developing future fluorimetric sensors.
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İncele - DüzeltmeAçık Erişim2026Scopus SJRQ2Retraction Note: Synthesis of Bimetallic Nickel-Cobalt Nanoparticles Supported by Functional Multi-Walled Carbon Nanotubes by Chemical Methods: Characterization and Hydrogen Energy Generation (Topics in Catalysis, (2024), 67, 9-12, (606-614), 10.1007/s11244-024-01907-x)
Zare, Najmeh; Karimi, Fatemeh; Altuner, Elif Esra; Mashkoor, Hussein; Tiri, Rima Nour Elhouda; Gulbagca, Fulya; Bijad, Majede; Cherif, Ali; Sen, Fatih
The Editors-in-Chief have retracted this article because of errors and inconsistencies which raise concerns regarding the validity of the research reported in this work. A review conducted by the journal found that: The turnover frequency reported in the section entitled Catalytic Studies of Hydrogen Production was incorrectly calculated; There is no conclusive evidence that bimetallic Nickel-Cobalt nanoparticles associated with carbon nanotubes were synthesized, as the reported XRD pattern and TEM micrographs don’t support this result. Furthermore, the description of the synthesis procedure was considered to be lacking in substance; The differences between the average sizes of nanoparticles is not adequately explained. The authors were asked to comment on these concerns, but their explanation was deemed unsatisfactory. The Editors-in-Chief no longer have confidence in the research presented in this article. The authors disagree with this retraction.
- Kitap BölümüYalnız künye2026Artificial Intelligence-Assisted Design and Optimization of BioNanocomposites for Biomedical and Environmental Applications
Bozbeyoglu, Pinar; Kostas, Rabia Yasa; Altuner, Elif Esra; Elmas, Muzaffer
Bio-nanocomposites, produced from renewable resources, stand out as one of the promising next-generation material classes for both biomedical and environmental applications due to their biocompatible and biodegradable structures.However, the vast and complex design space of these materials, which depends on numerous variables including the type of biopolymer matrix and the type and concentration of the nanostructured filler, makes their optimization quite challenging with traditional “trial-and-error” based research methods.This study provides a general overview of an artificial intelligence (AI)-based methodology that holds the potential to overcome this complexity.In this context, the limitations of the traditional “forward screening” approach are discussed, and the “inverse design” paradigm, based on the idea of “designing a material with desired properties,” is proposed as a solution.The study outlines the potential roles of various AI tools in this field, from supervised learning models to deep learning approaches and optimisation algorithms.This theoretical framework is substantiated by practical case studies that range from drug delivery to sustainable packaging.The case studies demonstrate how AI not only enables the prediction of properties but also facilitates strategically developing materials for a particular function, thereby accelerating the discovery process.Finally, current challenges, such as data scarcity and the interpretability of models, are addressed, and future visions to overcome these obstacles, including physics-informed AI, autonomous discovery platforms, and human-AI partnerships, are discussed.It is concluded that this synergy has the capacity to stimulate a new era of innovation in sustainable materials science.
- Derleme MakaleAçık Erişim2026Scopus SJRQ2Sustainable Ammonia Production, Advances in Electrochemical, Photoelectrochemical, and Photocatalytic Technologies for Green Energy
Shahin, Musarat; Mohsin, Abdul Haseeb; Bibi, Aiman; Ahmad, Ihtisham; Altuner, Elif Esra; Aldemir, Ozan; Durmusoglu, Senol; Yilancilar, Mehmet Sabit; Tanriverdi, Yavuz; Acar, Esra
Substantial advances have been made since the 1970s in reducing the environmental impacts of ammonia production. Renewable-driven electrochemical synthesis offers a promising pathway to decarbonize ammonia production. This review examines an integrated route in which hydrogen is generated photoelectrochemically under concentrated solar irradiation and subsequently used in electrochemical ammonia synthesis. Photoelectrochemical cells are fabricated by electrostatically depositing photosensitive particles onto cathodes to enhance light-driven hydrogen production. Hydrogen production rates and ammonia yield depend strongly on temperature and electrolyte composition. The synthesized hydrogen is fed into a molten salt electrochemical reactor that operates at atmospheric pressure and receives nitrogen from a dedicated supply. This combined solar–electrochemical approach can produce low-carbon ammonia with improved safety and reduced environmental impact, offering a scalable alternative to conventional processes.
AtıfScopus1OpenAlex1İncele - MakaleYalnız künye2026Scopus SJRQ3Synthesis of β-Lactam Conjugates of Thiadiazine Thiones as a New Class of Anti-Nociceptive Agents
Mohsin, Abdul Haseeb; Torlak, Yasemin; Altuner, Elif Esra; Aldemir, Ozan; Khan, Rasool; Issa, Ghassan; Zafar, Salman; Bibi, Aiman; Khan, Misbah Rafiq; Khan, Huma
A series of newly synthesized β-lactam conjugates of thiadiazine-2-thiones (TDZ-2T) were prepared by reacting various primary amines with carbon disulfide and potassium hydroxide, followed by the addition of formaldehyde and β-lactam antibiotics, including cefaclor and cefadroxil, in phosphate buffer. The synthesized substances were evaluated for their in vitro antimicrobial activity against P. aeruginosa and E. coli. All the substances exhibited activity against each forms of bacterial types, with 1e, 1f, 1g, 2a, and 2b showing the most significant activity. Additionally, the anti-nociceptive impact of the prepared substances was analyzed by the hot plate technique. Substances 1a, 1b, 1d, 1f, 1g, and 2a demonstrated notable activity at dosages of 80 mg/kg, as evidenced by a significant enhancement during the lag phase. Intact binding studies of the synthesized substance were also performed and showed a good binding interaction with the binding site of the in silico cyclooxygenase-2 (COX) enzyme.
AtıfScopus1OpenAlex1İncele - Kitap BölümüYalnız künye2026Smart Nanocarriers and AI-Driven Release Systems for Targeted Antibiotic Delivery
Kostas, Rabia Yasa; Bozbeyoglu, Pinar; Altuner, Elif Esra; Elmas, Muzaffer
The antimicrobial resistance (AMR) crisis is not merely a consequence of the emergence ofresistant pathogens. Furthermore, the remaining shortcomings oftraditional antibiotic production and development processes have become a profound health threat, exacerbated by their pharmaceutical and pharmacokinetic limitations. This book chapter redefines the AMR crisis as a problem of drug and treatment discovery as well as drug delivery to target tissues, and examines the technological angle emerging at the intersection of nanotechnology and artificial intelligence (AI) in response to this problem. This review begins by examining the problems inherent in traditional antibiotic architecture, such as systemic toxicity, low bioavailability, poor stability, and, most importantly, the inability to penetrate protected sites such as bacterial biofilms or intracellular bunkers. Copyright © 2026 by IGI Global Scientific Publishing. All rights reserved. No part of this publication may be reproduced, stored or distributed in any form or by any means, electronic or mechanical, including photocopying, without written permission from the publisher. Use of this publication to train generative artificial intelligence (AI) technologies is expressly prohibited. The publisher reserves all rights to license its use for generative AI training and machine learning model development.
- MakaleYalnız künye2026Scopus SJRQ3Biogenic Silver Nanoparticles from Citrus reticulata Peels for Ultrasensitive Electrochemical Sensing of 4-Aminobenzenesulfonamide
Dar, Umar Ali; Altuner, Elif Esra; Akocak, Suleyman; Issa, Ghassan; Ozalp, Veli Cengiz
Increasing utilization of sulfonamide derivatives as antibacterial agents has created serious challenges in terms of environmental pollution and antimicrobial resistance. In this respect, there is a compelling need for a highly sensitive and selective analytical tool for detecting such antibiotics in trace concentrations. This work represents a green strategy for developing an electrochemical biosensor for the determination of 4-aminobenzenesulfonamide based on bio-functionalized silver nanoparticles (Ag NPs) prepared from peel extract of Citrus reticulata fruit. The phytochemicals present in the peel extracts played a dual role of reduction and stabilization during the synthesis of Ag NPs. Synthesized NPs were well characterized through scanning electron microscopy (SEM), X-ray diffraction (XRD), Ultraviolet spectroscopy (UV–Vis), and Fourier infrared spectroscopy (FTIR) techniques. The Ag NPs showed considerable improvement in electrocatalysis in comparison to the bare glassy carbon electrode. The fabricated sensor gave an excellent linear calibration curve with a high value of R2 (=0.999), along with a low limit of detection (LOD = 0.65 µM) and limit of quantification (LOQ = 2.1 µM).
- MakaleAçık Erişim2026Scopus SJRQ1Circulating Ghrelin, Nesfatin-1, and Vaspin Levels Across Glycemic Control Categories in Type 2 Diabetes Mellitus: A Cross-Sectional Study
Akkus, Suheda; Saricam, Orkun; Kavruk, Murat; Sariyildiz, Gulcin Turkmen; Benguboz, Fatma Busra; Sirin, Berna Yilmaz; Altuner, Elif Esra; Dursun, Ali Dogan; Ozalp, Veli Cengiz
Background/Objectives: Diabetes mellitus is characterized by chronic hyperglycemia, insulin resistance, and low-grade inflammation, and adipose-tissue-derived adipokines are increasingly implicated as regulators of glucose homeostasis. This study compared circulating ghrelin, nesfatin-1, and vaspin levels across three glycemic-control categories defined by HbA1c and evaluated their association with glycemic status. Methods: In this cross-sectional comparative study, serum ghrelin, nesfatin-1, and vaspin were measured by enzyme-linked immunosorbent assay (ELISA) in 161 adults stratified into three groups: HbA1c 6.0–8.4% (n = 55), HbA1c ≥ 8.5% (n = 52), and non-diabetic controls with HbA1c < 6.0% (n = 54). Distributional assumptions were tested with the Kolmogorov–Smirnov and Shapiro–Wilk tests. Because all three adipokines deviated from normality, the primary omnibus comparison was the Kruskal–Wallis test, followed by Dunn’s post hoc test with Bonferroni adjustment; effect sizes are reported with 95% confidence intervals. Group differences were additionally examined after adjustment for age and sex, and HbA1c was analysed as a continuous variable. Results: Ghrelin (Kruskal–Wallis p = 0.726) and vaspin (p = 0.364) did not differ among the three groups. Nesfatin-1 differed significantly (H = 15.16, p < 0.001, ε2 = 0.095) and non-monotonically: concentrations were higher in the HbA1c 6.0–8.4% group than in controls (median 824 versus 650 pg/mL; Dunn p = 0.018) and than in the HbA1c ≥ 8.5% group (824 versus 600 pg/mL; p < 0.001), whereas the HbA1c ≥ 8.5% and control groups did not differ (p = 0.909). The nesfatin-1 difference persisted after adjustment for age and sex (p < 0.001) and after excluding controls with impaired fasting glucose (p < 0.001). Within the diabetic participants, nesfatin-1 correlated inversely with continuous HbA1c (ρ = −0.373, p < 0.001). Conclusions: Nesfatin-1, but not ghrelin or vaspin, differed significantly between HbA1c-defined glycemic-control categories in a non-monotonic manner, with the highest concentrations in the intermediate-HbA1c group. Because body mass index, diabetes duration, and antidiabetic medication were not available, and because the design is cross-sectional, these between-group differences cannot be interpreted as a within-person trajectory or attributed to glycemic status independently of adiposity. These exploratory findings require confirmation in larger, prospective, BMI- and medication-adjusted cohorts before nesfatin-1 can be considered a candidate biomarker.
- MakaleYalnız künye2026Scopus SJRQ3Development of Fluorimetric Method for Controlled Drug Release From Vinyl Propionate-co-Maleic Anhydride Polymer Modified With Paracetamol
Memis, Yilmaz; Gunduz, S. Beniz; Altuner, Elif Esra; Tatli, Havva Nur; Ozen, Gurkan; Okudan, Ahmet; Civil, Serife; Dar, Umar Ali
A novel pH-responsive polymeric drug delivery system is developed by covalently binding the active pharmaceutical ingredient paracetamol (PAR) to a synthesized vinyl propionate-co-maleic anhydride (VPR-co-MA) copolymer. The controlled release of PAR from the resulting VPR-co-MA-PAR conjugate was investigated in vitro at various physiological pH values (2.0, 4.5, 7.4, and 9.0) at 37°C over a 6 h-period. A fluorimetric method was utilized to quantify the released PAR, with optimal excitation and emission wavelengths determined to be 330 and 433 nm, respectively. The results demonstrated a distinct pH-dependent release profile. After 6 h, the cumulative drug release was significantly suppressed at acidic gastric pH 2.0 (42.23%), whereas it was substantially higher at neutral and alkaline conditions, reaching 71.29% at pH 7.4 and a maximum of 74.46% at pH 9.0. The pronounced difference in release rates confirms the system's ability to limit premature drug release in the stomach while promoting targeted delivery in the intestinal tract. This VPR-co-MA-PAR conjugate shows significant promise as a carrier for the controlled oral delivery of paracetamol.
- MakaleAçık Erişim2025Erbia - Katkılı İtriya - Stabilizeli Serya - Zirkonyum Bazlı Nanoseramiklerın Sentezi ve Karakterizasyonu
Durmusoglu, Senol; Altuner, Elif Esra
Erbia- katkılı itriya - stabilizeli seryum-zirkonyum bazlı nanokristalin seramikler, ön seramik hibrit polimer çözeltileri olarak metal asetat ile polimerden seramiğe dönüşüm tekniği ile üretildi. Numuneler Taramalı Elektron Mikroskobu, Fourier Dönüşümlü Kızılötesi Spektroskopisi ve X-ışını Kırınımı ile karakterize edildi. Nanokristalit boyutu Scherrer eşitliği ile değerlendirildi. En az olan kristal değer ve kristalit boyutu, atom ağırlığına oran olarak Zr (%74), Y (%11), Ce (%10) ve Er (%5) içeren numune için elde edildi. Taramalı Elektron Mikroskobu sonuçları itriya içeriğindeki artışın taneciklerin aglomerasyonunu artırdığını göstermektedir. Karışık oksit yapıların başarılı sentezi, belirgin metal-oksijen bağlarının (Zr– O, Ce–O ve Er–O) gelişimini ve organik grupların tamamen parçalanmasını da gösteren FTIR spektrumları ile doğrulandı. Üretilen nanoseramikler, birleşik FTIR, XRD ve SEM incelemelerine göre, ince parçacık şekli, homojen faz gelişimi ve artan katkı maddesi içeriğiyle artan yapısal kararlılık göstermektedir.
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İncele - MakaleYalnız künye2025Scopus SJRQ3Synthesis and Characterization of Iron-Cobalt@Activated Carbon Nanoparticles for Electrochemical Sensing of Dopamine Neurotransmitters
Altuner, Elif Esra; Janabi, Muhammad Yousif Ali Al; Sen, Fatih; Dar, Umar Ali
Activated carbon-supported FeCo@AC nanoparticles (FeCo@ACNPs) were synthesized for catalytic activity and extend shelf life by incorporating bimetallic iron-cobalt nanoparticles (FeCoNPs). The synthesized nanoparticles were characterized using fourier-transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and X-ray diffraction (XRD) to elucidate their structural and morphological properties. FTIR analysis confirmed the presence of metal nanoparticles with characteristic peaks at 590–612 cm⁻¹. TEM analysis revealed an average nanoparticle size of 10.71 ± 3.52 nm, while XRD results indicated crystalline dimensions of 7.2 nm. FeCo@ACNPs were further modified onto a glassy carbon electrode, and their sensor activity was evaluated for dopamine detection in the linear range of 0.1–1 mM. The study determined a limit of detection (LOD) of 0.65 µM and a limit of quantification (LOQ) of 1.97 nM. These findings not only reinforce previous studies on dopamine sensing but also provide valuable understanding of dopamine sensing and highlight its potential for health applications, particularly in diagnosing neurological disorders like Parkinson’s disease by monitoring dopamine levels.
AtıfScopus5WoS1İncele - MakaleYalnız künye2025Scopus SJRQ2Synthesis, characterization and biological evaluation of new Coumarin-Ferrocene conjugates as antitumor agents
Taner, Bilge; Mahmood Mahmood, Aysha Hasan; Karakurt, Serdar; Altuner, Elif Esra; Dar, Umar Ali
Two novel ferrocene-appended coumarin derivatives, FcL1 and FcL2, were synthesized and characterized using various analytical techniques which includes IR, UV, 1H NMR, 13C NMR and mass spectroscopy. 1H NMR revealed signals for the substituted cyclopentadiene ring at δ 4.80 and δ 4.61 ppm (FcL1) and δ 4.81 and 4.60 ppm (FcL2), while 13C NMR confirmed azomethine carbons at δ 162.95 and 160.43 ppm, respectively. UV–Vis analysis confirmed the successful molecular design of FcL1 and FcL2, achieving the desired electronic properties. Cytotoxic and antiproliferative effects of FcL1 and FcL2 were evaluated against metastatic colorectal carcinoma (CRC) DLD-1 cells and healthy colon epithelium CCD-18Co cells using the Alamar Blue assay. Both compounds inhibited DLD-1 cell proliferation in a dose-dependent manner, with IC50 values of 64.3 ± 2.4 µM (FcL1) and 67.1 ± 3.1 µM (FcL2). Minimal cytotoxic effects were observed on healthy colon epithelial cells at the same concentrations (p < 0.001). Fluorescence microscopy revealed the localization of both compounds in the cytoplasm and nucleus of cells. These findings suggest FcL1 and FcL2 as potential candidates for colorectal cancer therapy, exhibiting selective cytotoxicity toward cancer cells with low toxicity to healthy cells.
AtıfScopus8WoS6OpenAlex7İncele - MakaleYalnız künye2025Scopus SJRQ3Thermodynamic and Kinetic Performance of Highly Efficient ZnO/Co@f-MWCNT Catalysts for Hydrogen Production
Mashkoor, Hussein; Gulbagca, Fulya; Tiri, Rima Nour Elhouda; Altuner, Elif Esra; Halvaci, Ebru; Bennini, Nihed; Doner, Nimeti; Sen, Fatih
The use of catalysts is one of the most important parameters in producing hydrogen energy. Zinc-oxide/cobalt nanoparticles were synthesized by chemical methods and doped on f-MWCNT (ZnO/Co@f-MWCNT NPs) as a supporting material. Various characterization techniques were used to examine the structural and morphological properties of the synthesized nanoparticles (ZnO/Co@f-MWCNT NPs). According to the XRD characterization results, the average crystal particle size of NPs was calculated as 2.10 nm, and according to TEM analysis, the average particle size was calculated to be 2.24 ± 0.5 nm. The catalytic activity of ZnO/Co@f-MWCNT NPs toward hydrogen production was determined using NaBH4 as the hydrogen source. Studies were carried out on how the catalytic activity of ZnO/Co@f-MWCNT NPs would vary in different parameters. The average reusability performance achieved after 4 cycles for hydrogen production is 89%. Turnover frequency (TOF) according to catalytic activity, activation energy (Ea), enthalpy (∆H), and entropy (∆S) were found to be 2467.4 min−1, 16.36 kj/mol, 13.79 kj/mol and -122.8 J/mol.K, respectively. This study provides guidance for hydrogen production, and other energy studies, and supporting agents in the future.
AtıfScopus2OpenAlex1İncele - Kitap BölümüYalnız künye2025Porphyrin composite materials analysis, design, manufacturing and production
Altuner, Elif Esra; Sen, Fatih; Dar, Umar Ali
This chapter explains the analysis, design, and production of porphyrin-induced derivatives with reference to the relevant sources. Porphyrin has a colorful structure by altering the position of these rings, porphyrin derivatives can be formed, and metals can be included in complex structures. The analysis of porphyrin is conducted under three main headings volta metric analysis, spectro photometric analysis, and HPLC analysis. Chlorines and bacterioclorines, n-substituted por-phytes, aza porphytes, ftalocyanins, and purpurines are analogs of porphyrins. The production of porphyrin varies based on synthesis methods. These differences arise from aldehydes and ketones, and dipiromethan A2BC tetra-substituted por-phyrin, trans-substituted porphyrin synthesis, and symmetrical meso-substituted synthesis methods have been discussed.
- Kitap BölümüYalnız künye2025Advanced characterization methods and characterization types for porphyrins
Altuner, Elif Esra; Sen, Fatih; Dar, Umar Ali
This chapter delves into the comprehensive structural descriptions of porphyrins, focusing on their physico-chemical features. The chapter offers a comprehensive description of the numerous analytical techniques used in the characterization and methodologies for structural determination. This encompasses NMR (H-NMR and C-NMR), Raman, and UV-Vis. TEM, AFM, and DLS were utilized to examine their topography and morphology. Every characterization technique is thoroughly described, with each component highlighted in separate sections.