Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Büyükkiliç Altinbasak, Betul(2)
- Demirci, Betul(2)
- Issa, Ghassan(2)
- Zengin Kurt, Belma(2)
- Altinbasak, Betul Buyukkilic(1)
- Arapi, Berk(1)
- Arslan, Caner(1)
- Aydemir, Birsen(1)
- Bahtiyar, Nurten(1)
- Balekoglu, Aleyna(1)
- Baykara, Onur(1)
- Cinemre, Fatma Behice(1)
- Dinç, Harika Oyku(1)
- Ecevit Genç, Gulay(1)
- Hacioglu, Yalcin(1)
- Hamid, Rauf(1)
- Kanigür-Sultuybek, Gonul(1)
- Kiziler, Ali Riza(1)
- Mayda, Pelin Yuksel(1)
- Onaran, Ilhan(1)
- Sari, Silva Polat(1)
- Sayilan, Aylin Aydin(1)
- Tel, Cigdem(1)
- Terzioglu, Fusun(1)
- Çaliskan, Reyhan(1)
- Öner, Tuba(1)
- Özen, Nurten(1)
- Özkaptan, Bilge Bal(1)
Yayınlar
- MakaleAçık Erişim2023Oxidized Low Density Lipoprotein Receptor 1 3'UTR 188C>T Gene Polymorphism in Patients with Coronary Artery Bypass Grafting
Bahtiyar, Nurten; Baykara, Onur; Hacioglu, Yalcin; Öner, Tuba; Cinemre, Fatma Behice; Aydemir, Birsen; Onaran, Ilhan; Arslan, Caner; Tel, Cigdem; Hamid, Rauf
Aim: Coronary artery disease (CAD) is a pathological process characterized by atherosclerotic plaque accumulation in the epicardial arteries. Inflammation and high lipid levels play a role in pathological changes in atherosclerosis. Besides traditional risk factors, genetic factors such as single nucleotide polymorphism (SNPs) can be involved in disease process. In this study, we aimed to evaluate the effects of oxidized low density lipoprotein receptor 1 (OLR1) 3'UTR188C>T gene polymorphism, C -reactive protein (CRP), and lipid status in patients with coronary artery bypass grafting (CABG). Materials and Methods: The study population consisted of 109 CAD patients who had undergone CABG, and 127 healthy controls. The OLR1 3'UTR188C>T polymorphism was genotyped using PCR-RFLP technique. Serum CRP, high -density lipoprotein -cholesterol (HDL-C), and low -density lipoprotein -cholesterol (LDL-C) levels were measured with an automatic biochemistry analyzer. Results: The distribution of the OLR1 3'UTR188C>T genotypes and alleles did not differ significantly between CAD patients with CABG and controls. Serum CRP levels were increased in patients compared to the control group (p<0.001), but HDL-C, and LDL-C levels were not different between two groups. Traditional risk factor such as cigarette smoking, alcohol use, family history, diabetes mellitus and hypertension were increased in patients compared to the control group (p<0.001, for each). The CRP levels were higher in patients with the TT, CT, and CC genotypes than in controls with the same genotypes (p<0.001, p<0.01, and p<0.05, respectively). Conclusion: OLR1 3'UTR 188C>T polymorphism may not be involved in susceptibility to atherosclerosis. However, traditional risk factors in atherosclerosis such as smoking, alcohol consumption, family history, hypertension, diabetes mellitus, and circulating CRP levels were increased in our CABG population. The evaluation of OLR1 3'UTR188C>T and different OLR1 SNPs may be useful for their single and combined effects in atherosclerosis.
AtıfTR Dizin1
İncele - MakaleAçık Erişim2023Turkish Validity and Reliability Study of the Fear of Coronavirus Disease-2019 Scale: A Research on Nursing Students
Özkaptan, Bilge Bal; Özen, Nurten; Sayilan, Aylin Aydin; Terzioglu, Fusun
BACKGROUND/AIMS: The coronavirus disease-2019 (COVID-19) outbreak has taken its toll on individuals' mental health and physical health worldwide. Nurses, who play a key role in patient care, experience greater fear and anxiety due to their high-risk exposure to COVID-19 infection. This also leads to anxiety among undergraduate nursing students. This study aimed to determine the validity and reliability of the Fear of COVID-19 Scale (FCV-19S) for Turkish nursing students.MATERIALS AND METHODS: The study was conducted with 351 nursing students from two different universities in Turkiye between May and June 2020. Participant characteristic form and the Turkish version of FCV-19S were utilized to gather the data. Psychometric tests including language validity, content validity, and reliability analyses were performed.RESULTS: The item total test correlation of all items varies between 0.537 and 0.637. The Explanatory Factor Analysis made to detect the factor design of the scale found the threshold factor loading value as 0.40. The scale's 7 items and single sub-dimension were related to the scale structure to to the Confirmatory Factor Analysis. The scale Cronbach's alpha value was determined as 0.833. The test-retest results, performed to determine the time invariance, revealed a high level of correlation between the two measurements with the Pearson correlation coefficient (r=0.734; p<0.05).CONCLUSION: A valid and reliable measurement tool was provided to Turkiye to assess nursing students' fears of COVID-19. The Turkish version of the scale can be utilized as a substantial and reliable estimation device in detecting the fear of coronavirus in nursing students.
- MakaleAçık Erişim2022Biological Activities and Chemical Composition of Turkish Sweetgum Balsam (Styrax Liquidus) Essential Oil
Büyükkiliç Altinbasak, Betul; Issa, Ghassan; Zengin Kurt, Belma; Demirci, Betul
Objective: The purpose of this present study was to make a chemical analysis of the composition of essential oil obtained from sweetgum balsam and to examine its antimicrobial, anticholinesterase, alpha-glucosidase inhibition, and antioxidant activities.Methods: The essential oil obtained by the hydrodistillation method was analyzed by gas chromatography-mass spectrometry systems. The antimicrobial activities of the essential oil were evaluated by disc diffusion and resazurin microplate methods, the anticholinesterase effect was determined by using in vitro AChE and BChE enzymes inhibition assays, and the antioxidant effect was evaluated by ABTS and CUPRAC methods.Results: The main components of the essential oil were determined as styrene (92.6%) and alpha-pinene (2.2%). The essential oil showed weak antimicrobial activity against K. pneumoniae, S. epidermidis but strong antimicrobial activity against A. baumannii, C. glabrata. It showed moderate inhibitory activity to AChE and BChE enzymes, and IC50 values were calculated as 36.5 mu g/mL and 69.5 mu g/mL, respectively. It also showed low inhibition of alpha-glucosidase (IC50 value was 637.2 mu g/mL) and a similar antioxidant effect in the CUPRAC and ABTS method (A0.5 value was 637.2 mu g/mL and IC50 value was 632.2 mu g/mL, respectively).Conclusion: Styrax Liquidus essential oil can be considered a natural antimicrobial agent due to its strong antimicrobial activity capacity against A. baumannii and C. glabrata strains.
AtıfWoS5OpenAlex5TR Dizin2İncele - MakaleAçık Erişim2022Anticholinesterase and Anti-inflammatory Activities of Essential Oils of Naturally Grown Daucus L. Species in Turkey
Büyükkiliç Altinbasak, Betul; Ecevit Genç, Gulay; Zengin Kurt, Belma; Demirci, Betul
Objective: This present study was conducted to determine the interspecific chemical variability and evaluate the biological effects of the essential oils of Daucus L. species growing naturally in Turkey. The species were D. carota, D. broteri, D. guttatus, D. littoralis, D. involucratus and D. conchitae (endemic).Methods: The essential oils were obtained from fruit samples by distillation method and were analyzed both by GC-FID and GC-MS. The anti-inflammatory and anticholinesterase effects of the essential oils were investigated. The anti-inflammatory effect was evaluated by in vitro LOX enzyme inhibition activity. The anticholinesterase effect was tested on AChE and BChE enzymes. Results: The components, ratios, and yields of D. carota essential oils differed depending on the locations where the samples were collected. The main components were detected as carotol (1-74.6%), 13-bisabolen (0.9-62.4%), 11 alpha H-himachal-4-en-113- ol (0.3-49.4%), trans-methylisoeugenol (1-45.7%). The main volatile compounds were found in D. broteri, D. guttatus, D. involucratus, D. littoralis, D. conchitae as 13-sinensal (30.4%), methyleugenol (30.5%), methyleugenol (40.9%), alpha-humulene (29.4%), methyleugenol (29.6%) respectively. The essential oils didn't exhibit anti-inflammatory activity. Two essential oil samples of D. carota showed high anticholinesterase effects compared to the standard. The AChE IC50 was calculated as 6.04 +/- 0.30 mu g/mL, 2.15 +/- 0.10 mu g/mL (Galantamine IC50 1.13 +/- 0.02 mu g/mL) and BChEIC50 11.32 +/- 0.20 mu g/mL, 31.03 +/- 0.02 mu g/mL (Galantamine IC50 12.15 +/- 0.36 mu g/mL). These essential oils contained high levels of 11 alpha H-himachal-4-en-113-ol (25.04%, 49.42%).Conclusion: Because of their anticholinesterase potential, some D. carote essential oils can be evaluated in the preparation of pharmaceutical or nutraceutical products as a complementary therapy for Alzheimer's disease by standardizing their components.
AtıfWoS4OpenAlex4İncele - MakaleAçık Erişim2022Bioactive Components and Antioxidant and Antimicrobial Activities of Rhus coriaria, a Sumac Species found in Turkey
Çaliskan, Reyhan; Sari, Silva Polat; Altinbasak, Betul Buyukkilic; Dinç, Harika Oyku; Balekoglu, Aleyna; Issa, Ghassan; Mayda, Pelin Yuksel
Objective: In our study, it was aimed to analyze the antioxidant and antimicrobial activities of the extracts of the fruits of Rhus coriaria L. (sumac) species collected from Gaziantep.Methods: Ethanol extracts of 80% (R2) and 100% (R3) were prepared from Rhus coriaria fruits. Chemical analysis of the extracts were performed by liquid chromatography-high resolution mass spectrometry method, their antioxidant activities were investigated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity, and their antimicrobial activity was investigated using broth microdilution method.Results: In the chemical analysis of R2 and R3 extracts, fumaric acid, an organic acid with the highest concentration, was found at concentrations of 31076.55 and 23348.37 mg/kg, respectively. While the phenolic components with the highest concentration in R2 were observed as hyperoside (622.24 mg/kg), ellagic acid (343.63 mg/kg) and p-coumaric acid (182.91 mg/kg), the phenolic components with the highest concentration in R3 were observed as ellagic acid (607.30 mg/kg), hyperoside (440.41 mg/kg) and p-coumaric acid (178.61 mg/kg). In antioxidant activities of R2 and R3 extracts, DPPH free radical scavenging activities were found to be 70.78%+/- 0.002% and 11.19 +/- 0.001%, respectively. Antimicrobial activities of R2 and R3 extracts were found to be 125 and <3.9 mu g/ mL in S. aureus strain ATCC 25923, 15.625 and 31.25 mu g/mL in A. baumannii strain ATCC 19606, 62.5 mu g/mL in H. pylori strain ATCC 43504, 62.5 mu g/mL in C. glabrata strain ATCC 2001, <3.9 mu g/mL in C. albicans strain ATCC 66027, respectively.Conclusion: The higher antioxidant activity in the R2 extract obtained from R. coriaria fruits grown in our country may be due to the higher phenolic component content compared to the R3 extract. It is thought that the more effective antimicrobial activity detected in the R3 extract may be due to the higher amount of ellagic acid compared to the R2 extract.
AtıfWoS6TR Dizin2İncele - DergiNAMIK KEMAL MEDICAL JOURNAL
- DergiCYPRUS JOURNAL OF MEDICAL SCIENCES
- DergiBEZMIALEM SCIENCE