Sürdürülebilir Kalkınma Amaçları
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- MakaleAçık Erişim2024Scopus SJRQ3Inhibition of pancreatic cancer via LPAR4 receptor with a de novo drug complex design using theoretical organic chemistry: Comprehensive molecular docking, molecular dynamics
Agar, Soykan; Arasan, Yaren; Akkurt, Barbaros; Ulukaya, Engin
The present work relates to a de novo organic chemistry involved drug design and repurposing discovery of a Quercetin and Ascorbic Acid complex formation with the IUPAC nomenclature of ‘’3-((2S)-2-(3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl)-2-hydroxyethoxy)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one’’ to suppress pancreatic cancer via the inhibition of LPAR4 receptor. This was achieved with molecular docking and molecular dynamics studies and found that Ascorbic Acid is docking manoeuvre assistant for Quercetin to form Hydrogen bonds and Covalent bonds to shut down LPAR4 receptor with excellent inhibition constant. This study may very well lead to further in vitro organic synthesis, characterization and cell line results and in vivo/ex ovo animal testing for etherical bound Quercetin and Ascorbic Acid complex.
AtıfScopus1OpenAlex3TR Dizin3
İncele - MakaleAçık Erişim2022Scopus SJRQ3The Anatomical Features of Endemic Hypericum spectabile Jaub. & Spach from Türkiye
Altinbaşak, Onur; Kültür, Şükran
Hypericum L. genus is used as a soothing, antiseptic and antispasmodic agent under the name of “kantaron, kılıçotu, kanotu, yaraotu, kuzukıran, koyunkıran, binbirdelik” otu in Turkish folk medicine. This study reveals the anatomical features of H. spectabile belonging to Drosanthe sections of Hypericum L. genus. The stem, leaf and root anatomical features of the plant is investigated for the first time in this study. In the stem sections of stem there are two rows of epidermal tissue. The epidermis is surrounded by a thick cuticle layer. Just below the cortex, parenchyma covers a large area. Phloem has A type secretory secretory cells. Xylem is composed of sclerenchymatic cells and tracheary elements in vascular bundles. The pith is composed of parenchymatic cells. In the section of the root there are four-five rows of periderm. Below this tissue there is cortex parenchyma with intercellular spaces. Inward, there are phloem and xylem tissues. The pith consists of parenchymatic cells. Leaf mesophyll layer has palisade parenchyma on both surfaces. Leaf is equifacial. Collenchyma tissue is in four-five rows on the upper and lower surfaces of the middle vein. The leaf is amphistomatic. Stomata belong to anisocytic types.
- DergiJournal of Research in Pharmacy