Sürdürülebilir Kalkınma Amaçları
Yazarlar
Yayınlar
- Kitap BölümüYalnız künye2024Analytical techniques for the characterization of quinone-based materials
Altuner, Elif Esra; Sen, Fatih; Dar, Umar Ali
Quinone is a compound that has a ring structure and contains oxygen in its body and is found in living things and plants. Being antibacterial and antifungal is an important advantage for living things, but it becomes a threat that causes deadly diseases for living things, due to the cyclic structure and oxygen molecule reacting with UV rays and various chemicals. For this reason, the detection of quinone and quinone-based materials is very important. The determination of quinone and quinone materials is provided by utilizing various characterization techniques such as electrochemical studies, UV-Vis studies, HPLC, and FTIR. This chapter presents a broad theoretical perspective to the literature by citing the relevant parts of quinone and quinone-based studies.
- Kitap BölümüYalnız künye2024Clinical development of quinone-based drugs
Altuner, Elif Esra; Issa, Ghassan; Ozalp, Veli Cengİz; Aldemir, Ozan; Torlak, Yasemin; Dar, Umar Ali
This chapter provides a detailed explanation of the clinical investigations, pharmacological effects, and characteristics of quinone and quinone derivatives, along with references to pertinent sources. Although quinones have an oxygen group in their structure, they are quickly oxidized and interact with reactive oxygen species. This demonstrates how quinones work as drugs. Quinones and their derivatives are used as medications to treat a wide range of diseases, including cancer, lung, kidney, brain, and tumor disorders. Each of the following has effects on a different area of health; lapochols, anthraquinones, naphthoquinone and its derivatives, and other wide range of quinone derivatives are thoroughly explored in this chapter.
- Kitap BölümüYalnız künye2024Commercialization of quinone-based drugs
Altuner, Elif Esra; Sen, Fatih; Dar, Umar Ali
In this chapter, the antibiotic drug effects of quinone and quinone derivatives are discussed in detail. Today, antibiotic drugs used against harmful pathogens work for a certain period, but these drugs become useless after a certain time or after a certain dose. This is because harmful microorganisms become resistant to these antibiotics after a certain threshold. For this reason, searches have been made that can replace antibiotics and are harmless. Quinone and quinone derivatives are one of these researches. Quinone and its derivatives show antibacterial, antiviral, and antifungal properties against various microorganisms. Quinones have the structure of cyclic diketones. Therefore, it is an advantage that it gives radicals easily as it resonates easily and thus has antioxidant properties in this reaction. The main quinone-based drugs used as antibiotic drugs are as follows: anthracyclines, mitomycin C, mitoxantrone, aziridinylbenzoquinones, streptonigrin, lapachols, and actinomycin D. Some of these drugs have anticancer and some have antitumor properties. This chapter can offer details on quinone and quinone derivatives-related commercial drug research.
AtıfScopus2OpenAlex1
İncele - Kitap BölümüYalnız künye2022Stability and release of bioactives from liposomes
Rauf, Muhammed Abdur
The health benefits of bioactive compounds have been proved beyond doubt, but their instabilities and poor bioavailabilities most often limit their full potential. Encapsulating them in vesicular carrier systems, such as liposomes or emulsions, protects the sensitive compounds against damaging factors and offers an opportunity to achieve controlled release, which in turn aims to enhance their bioavailabilities and efficacies. Liposomes and emulsions are regularly used to tackle the stability issues of bioactives, however, they themselves are susceptible to various chemical, physical, and biological instabilities. Different factors related to lipids, bioactives, and liposome size and lamellarity are known to affect both the stabilities and release behavior of liposomes. Liposomes show biphasic or triphasic release patterns with an initial burst release which is brought under control to achieve better release properties. Optimizing release-affecting factors, utilization of the bioactive–cyclodextrin complex, polymeric coating of liposomes, or encapsulation of liposomes into another polymeric matrix are reported to control the liposomal release behavior. Moreover, liposomes are designed to hold (slow or no release) their content until stimulated/triggered by some release-triggering mechanism like pH, temperature, ultrasound, etc. In comparison, double/multiple emulsion and polyelectrolyte coated multilayer emulsions can also offer controlled release of their payload. Liposomes, being made of natural ingredients, are an attractive choice as carriers for bioactives, although some challenges remain. The first is the destruction of liposomes by bile and lipases in the gastrointestinal tract, the most plausible route of administration for bioactives. In addition, they do not permeate through the gastrointestinal epithelial layers. A large amount (often 20%–30%) of cholesterol, a common ingredient required for liposome rigidity, also remains a concern for hypercholesterolemic people. However, our intense interest in bioactive substances can be expected to overcome these challenges in the near future.
AtıfScopus4OpenAlex3İncele