Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Akbulut, Yasin(2)
- Altuner, Elif Esra(2)
- Ozalp, Veli Cengiz(2)
- Acar, Esra(1)
- Ahmad, Ihtisham(1)
- Ak-Aksoy, Secil(1)
- Akgun, Emel(1)
- Akkus, Suheda(1)
- Aksoy, Fuat(1)
- Akyol, Betül(1)
- Aldemir, Ozan(1)
- Altinoz, Meric A.(1)
- Aygoren, Caner(1)
- Balik, Busra Akinalan(1)
- Baykal, Ahmet(1)
- Benguboz, Fatma Busra(1)
- Beykumul, Aysegul(1)
- Bibi, Aiman(1)
- Cengiz, Tolgahan(1)
- Cinarli, Fahri Safa(1)
- Cinarli, Sena(1)
- Cosar, Banu(1)
- Coskun, Senol(1)
- Demir, Tuncer(1)
- Duman, Busra Oncel(1)
- Durmusoglu, Senol(1)
- Dursun, Ali Dogan(1)
- Elmas, Muzaffer(1)
- Ercelik, Melis(1)
- França, Cíntia(1)
- Gouveia, Élvio Rúbio(1)
- Isik, Ozgen(1)
- Isman, Nurettin Eren(1)
- Issa, Ghassan(1)
- Karamustafaoglu, Ahmet(1)
- Kavruk, Murat(1)
- Kaya, Ekrem(1)
- Kilic, Teoman(1)
- Koz, Mitat(1)
- Krustrup, Peter(1)
Yayınlar
- Derleme MakaleAçık Erişim2026Scopus SJRQ2Sustainable Ammonia Production, Advances in Electrochemical, Photoelectrochemical, and Photocatalytic Technologies for Green Energy
Shahin, Musarat; Mohsin, Abdul Haseeb; Bibi, Aiman; Ahmad, Ihtisham; Altuner, Elif Esra; Aldemir, Ozan; Durmusoglu, Senol; Yilancilar, Mehmet Sabit; Tanriverdi, Yavuz; Acar, Esra
Substantial advances have been made since the 1970s in reducing the environmental impacts of ammonia production. Renewable-driven electrochemical synthesis offers a promising pathway to decarbonize ammonia production. This review examines an integrated route in which hydrogen is generated photoelectrochemically under concentrated solar irradiation and subsequently used in electrochemical ammonia synthesis. Photoelectrochemical cells are fabricated by electrostatically depositing photosensitive particles onto cathodes to enhance light-driven hydrogen production. Hydrogen production rates and ammonia yield depend strongly on temperature and electrolyte composition. The synthesized hydrogen is fed into a molten salt electrochemical reactor that operates at atmospheric pressure and receives nitrogen from a dedicated supply. This combined solar–electrochemical approach can produce low-carbon ammonia with improved safety and reduced environmental impact, offering a scalable alternative to conventional processes.
AtıfScopus1OpenAlex1
İncele - MakaleAçık Erişim2026Scopus SJRQ1Circulating Ghrelin, Nesfatin-1, and Vaspin Levels Across Glycemic Control Categories in Type 2 Diabetes Mellitus: A Cross-Sectional Study
Akkus, Suheda; Saricam, Orkun; Kavruk, Murat; Sariyildiz, Gulcin Turkmen; Benguboz, Fatma Busra; Sirin, Berna Yilmaz; Altuner, Elif Esra; Dursun, Ali Dogan; Ozalp, Veli Cengiz
Background/Objectives: Diabetes mellitus is characterized by chronic hyperglycemia, insulin resistance, and low-grade inflammation, and adipose-tissue-derived adipokines are increasingly implicated as regulators of glucose homeostasis. This study compared circulating ghrelin, nesfatin-1, and vaspin levels across three glycemic-control categories defined by HbA1c and evaluated their association with glycemic status. Methods: In this cross-sectional comparative study, serum ghrelin, nesfatin-1, and vaspin were measured by enzyme-linked immunosorbent assay (ELISA) in 161 adults stratified into three groups: HbA1c 6.0–8.4% (n = 55), HbA1c ≥ 8.5% (n = 52), and non-diabetic controls with HbA1c < 6.0% (n = 54). Distributional assumptions were tested with the Kolmogorov–Smirnov and Shapiro–Wilk tests. Because all three adipokines deviated from normality, the primary omnibus comparison was the Kruskal–Wallis test, followed by Dunn’s post hoc test with Bonferroni adjustment; effect sizes are reported with 95% confidence intervals. Group differences were additionally examined after adjustment for age and sex, and HbA1c was analysed as a continuous variable. Results: Ghrelin (Kruskal–Wallis p = 0.726) and vaspin (p = 0.364) did not differ among the three groups. Nesfatin-1 differed significantly (H = 15.16, p < 0.001, ε2 = 0.095) and non-monotonically: concentrations were higher in the HbA1c 6.0–8.4% group than in controls (median 824 versus 650 pg/mL; Dunn p = 0.018) and than in the HbA1c ≥ 8.5% group (824 versus 600 pg/mL; p < 0.001), whereas the HbA1c ≥ 8.5% and control groups did not differ (p = 0.909). The nesfatin-1 difference persisted after adjustment for age and sex (p < 0.001) and after excluding controls with impaired fasting glucose (p < 0.001). Within the diabetic participants, nesfatin-1 correlated inversely with continuous HbA1c (ρ = −0.373, p < 0.001). Conclusions: Nesfatin-1, but not ghrelin or vaspin, differed significantly between HbA1c-defined glycemic-control categories in a non-monotonic manner, with the highest concentrations in the intermediate-HbA1c group. Because body mass index, diabetes duration, and antidiabetic medication were not available, and because the design is cross-sectional, these between-group differences cannot be interpreted as a within-person trajectory or attributed to glycemic status independently of adiposity. These exploratory findings require confirmation in larger, prospective, BMI- and medication-adjusted cohorts before nesfatin-1 can be considered a candidate biomarker.
- MakaleAçık Erişim2025Scopus SJRQ1Prognostic Significance of mTOR Expression in Recurrence Following Hepatic Metastasectomy in Colorectal Cancer
Aksoy, Fuat; Ak-Aksoy, Secil; Karamustafaoglu, Ahmet; Tekin, Cagla; Ercelik, Melis; Tunca, Berrin; Duman, Busra Oncel; Isik, Ozgen; Ugras, Nesrin; Kaya, Ekrem
Surgery is one of the most effective treatment methods for liver metastases developing from primary colorectal cancer (CRC). Despite the widespread application of surgical approaches, recurrence rates remain substantial. Although chemotherapy is frequently employed, the supporting evidence for its efficacy in this context remains inconclusive. In the present study, we aimed to identify potential predictors of post-metastasectomy recurrence by analyzing clinical, pathological, and molecular features of both primary colorectal tumors and their corresponding hepatic metastases. Specifically, we evaluated the expression of epithelial–mesenchymal transition (EMT) markers, cancer stem cell (CSC) markers, and selected oncogenic mRNAs (RAS, mTOR, and CMYC) in tissue samples from 84 patients. RAS and CMYC are well-known proto-oncogenes involved in cell proliferation and survival, while mTOR functions as a central regulator of cell growth and metabolism. Following liver metastasectomy, intra-hepatic recurrence was observed in 40.5% of the cases. Among the molecular markers analyzed, the EMT transcription factor SNAIL—which plays a critical role in cancer cell invasion and metastasis—and mTOR exhibited significantly elevated expression in metastatic lesions from patients who experienced recurrence. While SNAIL expression did not show a clear association with the time to recurrence, increased mTOR expression in metastatic liver tissue was significantly associated with both shorter recurrence-free survival and diminished overall survival (p < 0.001). Results showed that mTOR expression levels could be a clinically relevant predictive indicator of remnant liver recurrence. In patients with liver metastases, the use of mTOR inhibitors may be considered after hepatic metastasectomy.
- MakaleAçık Erişim2025Scopus SJRQ2Effects of Rapid Maxillary Expansion on Pulmonary Function in Adolescents: A Spirometric Evaluation
Akbulut, Yasin; Oksayan, Rıdvan; Sokucu, Oral; Isman, Nurettin Eren; Demir, Tuncer
Objectives: Rapid maxillary expansion (RME) is widely used in orthodontics to correct transverse maxillary deficiencies. Beyond its skeletal and dental effects, RME may influence upper airway dimensions and respiratory function, particularly in growing individuals. This study aimed to evaluate the impact of RME on pulmonary function in adolescents using spirometric measurements. Materials and Methods: Fifteen adolescent patients (8 females, 7 males; mean age: 13.93 ± 2.89 years) diagnosed with maxillary transverse constriction underwent orthodontic treatment with acrylic-bonded RME appliances over a mean duration of 3.56 ± 0.67 months. Respiratory function was assessed via spirometry at baseline (T0) and one day after appliance removal (T1). Parameters recorded included peripheral oxygen saturation (SpO2), forced expiratory volume in one second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, and vital capacity (VC). Data were analyzed using the paired-samples t-test (for normally distributed variables) or the Wilcoxon signed-rank test (for non-normal distributions), with statistical significance set at p < 0.05. Results: Following RME treatment, all respiratory parameters showed a consistent upward trend but did not reach statistical significance. SpO2 increased from 96.98 ± 0.96% to 97.01 ± 0.98% (p = 0.925). VC rose from 2.86 ± 1.07 L to 3.03 ± 0.80 L (p = 0.626). The FEV1/FVC ratio improved from 90.88 ± 12.17% to 92.34 ± 7.37% (p = 0.742). Mean FEV1 increased from 2.61 ± 0.72 L to 2.72 ± 0.68 L (p = 0.518), while FVC rose from 2.87 ± 0.75 L to 2.96 ± 0.69 L (p = 0.547). No adverse effects were reported during the treatment period. Conclusions: This study identified a non-significant but consistent trend toward improved pulmonary function following RME in adolescents. These preliminary findings should be considered hypothesis-generating rather than confirmatory evidence, as none of the outcomes reached statistical significance. While the observed upward trends in oxygen saturation, lung volumes, and expiratory performance suggest potential respiratory benefits, larger-scale, controlled, and long-term studies incorporating both spirometric and anatomical airway assessments are needed to validate these observations.
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İncele - MakaleAçık Erişim2025Scopus SJRQ2Magnetic Resonance Imaging of Submental and Masticatory Muscle Morphology and Its Relationship with Temporomandibular Joint Structures
Öçbe, Melisa; Medişoğlu, Mahmut Sabri
Introduction: This study aimed to evaluate the submental and masticatory muscles in patients of different age groups using magnetic resonance imaging (MRI) and computed tomography (CT) methods, and investigate potential associations between muscle morphology, temporomandibular joint (TMJ) structures, and disc displacement. Materials and Methods: A total of 185 MRI scans were retrospectively analyzed to assess the thickness of the digastric, geniohyoid, mylohyoid, medial pterygoid, masseter, and lateral pterygoid muscles bilaterally. TMJ hard tissue changes were classified using computed tomography (CT). Correlations between muscle thickness and TMJ structures were analyzed using Pearson correlation coefficients, with statistical significance set at p < 0.05. Results: The study population included 110 females and 75 males, with a mean age of 50.08 ± 20.15 years. The largest age group was 51–75 years (41%), followed by 18–35 years (28%). Significant correlations were observed between muscle thickness and TMJ structures as follows: Right digastric muscle showed a significant association with right disc–condyle position (p = 0.02). Right mylohyoid muscle exhibited a strong correlation with right disc–condyle position (p = 0.004). Left medial pterygoid muscle was significantly correlated with left condyle pathology (p = 0.02). Left masseter muscle showed a significant correlation with left condyle pathology (p = 0.014). Condylar flattening was the most frequent pathology, observed in 58% of right condyles and 53% of left condyles. Disc displacement was present in 41% of right TMJs and 34% of left TMJs. Conclusions: This study highlights the important associations between masticatory and submental muscle morphology and TMJ structures, suggesting that muscle function may play a role in condylar positioning and disc alignment. These findings emphasize the need for comprehensive muscle evaluation in TMJ disorder (TMD) diagnosis and treatment planning.
AtıfScopus2WoS2OpenAlex2
İncele - MakaleAçık Erişim2025Scopus SJRQ2Lens Proteomics Provide Novel Clues for Cataractogenesis: Original Investigation and a Broad Literature Survey
Cosar, Banu; Nefesoglu, Mustafa Sehvar; Altinoz, Meric A.; Akgun, Emel; Sahin, Betul; Baykal, Ahmet; Serteser, Mustafa
Background: Previous proteomic studies provided valuable information about cataracts, but unclarified issues, such as sex and ethnicity-associated differences, remain. This study aimed to provide additional data on cataract-related proteins regarding age, sex, and cataract type. Methods: Twenty-six female and seven male Turkish cataract patients were screened for visual acuity and dysfunctional lens index. A nano-LC-MS/MS system and Progenesis QI software v3.0 were used for protein identification and quantification. The remaining data were evaluated with SPSS Version 29.0 software. Results: Proteins that showed age-associated changes were mainly involved in cytoskeletal organization. A glyoxalase enzyme, caveolin 1, and HS90B were lower, and RAB8B and ATP6V1B1 were higher in lenses in women. Proteins with lower levels in cataractous lenses than in transparent lenses included filensin and phakinin, concurrent with previous publications, and LCTL, GDI, HSPB1, and EIF4A2, not reported before. Corticonuclear cataracts constituted the only group showing depletions in putatively protective proteins, while the cortical type was the least influenced. ANXA1 and DNHD1 positively, and TCPD, SEC14L2, and PRPS1 proteins negatively correlated with visual acuity. Conclusions: This study revealed cataract-related proteins concurrent with earlier studies and new ones hitherto unreported. Despite the low number of patients investigated, the results merit further research, as these new proteins are highly likely to be involved in cataractogenesis.
AtıfScopus4WoS4OpenAlex4İncele - Derleme MakaleAçık Erişim2025Scopus SJRQ1Acute and Chronic Immunological Responses to Different Exercise Modalities: A Narrative Review
Sever, Ebru; Yılmaz, Sıla; Koz, Mitat
The relationship between exercise and immune function has been widely studied, yet findings remain inconsistent regarding how different exercise modalities and intensities influence acute and chronic immunological responses. Previous reviews have often focused on single exercise types or limited outcomes, leaving a gap for an integrated synthesis. This narrative review aims to address this gap by summarizing and comparing immunological effects across aerobic exercise, resistance training, high-intensity interval training (HIIT), blood flow restriction (BFR), isometric exercise, mind–body interventions, and hypoxic training. A structured narrative approach was adopted. Literature published between January 2000 and December 2024 was searched in PubMed, Scopus, and Web of Science. Experimental and observational studies on humans and animal models were included, with study selection and data extraction performed by two reviewers. Findings were synthesized thematically by exercise modality to capture both acute and chronic immune responses. Twenty-four eligible studies were identified. Aerobic and mind–body exercises consistently demonstrated anti-inflammatory and immunoprotective effects, including increased IL-10 production, improved T cell profiles, and reduced inflammatory markers. Isometric training showed favorable modulation of cytokines and T cell balance, while resistance training evidence was limited but suggested cortisol-lowering benefits. HIIT, BFR, and hypoxic exercise produced mixed results, often combining transient pro-inflammatory responses with immunological benefits. Acute and chronic immunological responses to exercise are highly modality- and intensity-dependent. Aerobic and mind–body interventions provide the most consistent benefits, whereas HIIT, BFR, and hypoxic training show variable effects. Further high-quality trials are needed to clarify mechanisms and guide exercise-based immune recommendations.
AtıfScopus11WoS8OpenAlex9İncele - MakaleAçık Erişim2025Scopus SJRQ2Optimizing Miniscrew Stability: A Finite Element Study of Titanium Screw Insertion Angles
Akbulut, Yasin; Ozdemir, Serhat
This study aimed to evaluate how different insertion angles of titanium orthodontic miniscrews (30°, 45°, and 90°) influence stress distribution and displacement in surrounding alveolar bone using three-dimensional finite element analysis (FEA), with a focus on biomechanical outcomes at the titanium–bone interface. The 90° insertion angle generated the highest stress in cortical bone (58.2 MPa) but the lowest displacement (0.023 mm), while the 30° angle produced lower stress (36.4 MPa) but greater displacement (0.052 mm). The 45° angle represented a compromise, combining moderate stress (42.7 MPa) and displacement (0.035 mm). This simulation-based study was conducted between January and April 2025 at the Department of Orthodontics, Kocaeli Health and Technology University. A standardized 3D mandibular bone model (2 mm cortical and 13 mm cancellous layers) was constructed, and Ti-6Al-4V miniscrews (1.6 mm × 8 mm) were virtually inserted at 30°, 45°, and 90°. A horizontal orthodontic load of 2 N was applied, and von Mises stress and displacement values were calculated in ANSYS Workbench. Stress patterns were visualized using color-coded maps. The 90° insertion angle generated the highest von Mises stress in cortical bone (50.6 MPa), with a total maximum stress of 58.2 MPa, followed by 45° (42.7 MPa) and 30° (36.4 MPa) insertions (p < 0.001). Stress was predominantly concentrated at the cortical entry point, especially in the 90° model. In terms of displacement, the 90° group exhibited the lowest mean displacement (0.023 ± 0.002 mm), followed by 45° (0.035 ± 0.003 mm) and 30° (0.052 ± 0.004 mm), with statistically significant differences among all groups (p < 0.001). The 45° angle showed a balanced biomechanical profile, combining moderate stress and displacement values, as confirmed by post hoc analysis. From a biomimetics perspective, understanding how insertion angle affects bone response provides insights for designing bio-inspired anchorage systems. By simulating natural stress dissipation, this study demonstrates that insertion angle strongly modulates miniscrew performance. Vertical placement (90°) ensures rigidity but concentrates cortical stress, whereas oblique placement, particularly at 45°, offers a balanced compromise with adequate stability and reduced stress. These results emphasize that beyond material properties, surgical parameters such as insertion angle are critical for clinical success.
AtıfScopus4WoS4OpenAlex4İncele - MakaleAçık Erişim2025Scopus SJRQ2The Impact of Femoral Anteversion Correction on Clinical Outcomes in Total Hip Arthroplasty for Adult Developmental Dysplasia of the Hip
Satılmış, Ahmet Burak; Cengiz, Tolgahan; Ülker, Ahmet; Mutlu, Tansel
Background: Total hip arthroplasty (THA) in adult patients with developmental dysplasia of the hip (DDH) presents unique surgical challenges due to altered hip anatomy and biomechanics. One of the most critical factors influencing surgical success is correcting femoral anteversion. This study evaluates the effects of different anteversion corrections (increased, unchanged, and decreased) during THA on clinical outcomes in adult Crowe type 3-4 DDH patients. Methods: A retrospective analysis was conducted on 130 patients who underwent THA with anteversion correction between 2008 and 2017 at a tertiary university hospital. Patients were divided into three groups: Group 1 (increased anteversion), Group 2 (unchanged anteversion), and Group 3 (decreased anteversion). Clinical outcomes were assessed using AOFAS and Lysholm scores, Q-angle measurements, and physical examinations, while radiological evaluations were performed to determine implant stability and complications. Results: Postoperative assessments show that increased anteversion is associated with higher rates of instability, knee dysfunction, and pain. Group 1 had significantly lower AOFAS scores (p < 0.001) and fell due to rotational deformity (25.6%). Group 2 exhibited the best clinical outcomes, with the lowest rates of instability and the highest functional scores. Group 3 had moderate functional improvements but a higher dislocation rate (17.1%) than Group 2. Conclusions: Our findings suggest that excessive changes in femoral anteversion during THA, remarkably increasing it, may negatively impact clinical outcomes by causing instability and pain. Preserving the anteversion angle as much as possible is the most favorable approach for optimizing functional recovery and implant stability. Further large-scale, long-term studies are required to confirm these findings and refine surgical strategies for DDH patients undergoing THA.
AtıfScopus10WoS11İncele - MakaleAçık Erişim2025Scopus SJRQ2Associations Between Pulmonary Function and Muscle Strength in Turkish National Karate Athletes
Tokgoz, Gurkan; Cinarli, Sena; Akyol, Betül; Aygoren, Caner; Beykumul, Aysegul; Larsen, Malte Nejst; Krustrup, Peter; França, Cíntia; Gouveia, Élvio Rúbio; Cinarli, Fahri Safa
Background: Respiratory efficiency is considered important in karate due to its role in sustaining muscular performance during high-intensity actions. This study examined the association between pulmonary function and isometric muscle strength in national-level karate athletes. Methods: A total of 23 elite karate athletes (mean age: 23.0 ± 2.3 (mean ± SD) years) participated in the study. Pulmonary function was assessed using a digital spirometer, while isometric handgrip, lower back, and leg strength were measured using a dynamometer. The correlation between pulmonary function and isometric strength was analyzed, and linear regression was employed to examine the predictive capacity of pulmonary parameters for muscle strength. Results: The results revealed significant correlations, ranging from large to very large, between pulmonary function and isometric muscle strength, with correlation coefficients from 0.639 to 0.812 (p < 0.01). Pulmonary function was strongly associated with isometric strength, accounting for 27% to 67% of the variance (p < 0.05). Multiple regression analysis revealed that pulmonary function parameters accounted for 71% of the variance in handgrip strength, 47% in leg strength, and 71% in back strength (p < 0.05). Conclusions: These findings highlight the strong associations between pulmonary function and isometric muscle strength in elite karate athletes. The results emphasize the importance of pulmonary health and respiratory muscle function in athletic performance, particularly for sports requiring high-intensity, dynamic movements like karate. Future longitudinal studies are needed to explore the mechanisms underlying the association and potential implications, and for training and performance optimization.
- Derleme MakaleAçık Erişim2024Scopus SJRQ1Myval Transcatheter Heart Valve: The Future of Transcatheter Valve Replacement and Significance in Current Timeline
Kilic, Teoman; Coskun, Senol; Mirzamidinov, Didar; Yilmaz, Irem; Yavuz, Sadan; Sahin, Tayfun
The Myval is a balloon-expandable transcatheter heart valve (THV) developed by Meril Life Sciences Pvt. Ltd. (Vapi, Gujarat, India) that has an innovative operator-friendly design that aids in improving deliverability and features precise deployment. Various clinical studies demonstrate its effectiveness and safety, making it a promising choice in valvular interventions. Myval has been successfully utilized as a transcatheter aortic valve implantation (TAVI) device in cases with conduction disturbances, bicuspid aortic valve anatomy, non-calcified aortic regurgitation, dysfunctional stenosed right ventricular outflow tract (RVOT) conduits, pulmonary valve replacement, mitral valve replacement, and valve-in-valve and valve-in-ring implantation procedures. Myval’s diverse sizes are also of key importance in complex cases of large annuli and complex anatomy. Further long-term studies are needed to consolidate these results. Its introduction signifies a significant advancement in cardiology, aiming to enhance patient outcomes and quality of life. In the present review, we provide an update on new-generation Myval THV series and review the available clinical data published to date with an emphasis on diverse use in specific clinical scenarios.
AtıfScopus13WoS13İncele - DergiLife
- DergiApplied Sciences (Switzerland)
- DergiDiagnostics
- DergiCatalysts
- DergiHealthcare (Switzerland)
- DergiBiomimetics
- DergiJournal of Clinical Medicine
- DergiBiomedicines