Yazarlar
- Öçbe, Melisa(20)
- Altuner, Elif Esra(13)
- Agar, Soykan(12)
- Dikmen, Yurdanur(10)
- Duru, Nevcihan(10)
- Issa, Ghassan(9)
- Kalemci, Serdar(9)
- Acar, Esra(8)
- Güneş, İrfan Botan(7)
- Terzioglu, Fusun(7)
- Zeybek, Arife(7)
- Özdemir, Tuğba(7)
- Aksakal, Fatma(6)
- Aldemir, Ozan(6)
- Arslan, Sevban(6)
- Coskun, Senol(6)
- Efetürk, Nida(6)
- Kuculmez, Ozlem(6)
- Sever, Ebru(6)
- Uyar, Yavuz(6)
- Yalçın, Suna Uysal(6)
- Adali, E.(5)
- Akkurt, Barbaros(5)
- Akpolat, Refiye(5)
- Alptekin, Dudu(5)
- Bozdağ, Gülistan Huriye(5)
- Dundar, Tolga Turan(5)
- Eker, Ayse Gul(5)
- Gezer, Derya(5)
- Gökçe, Esma(5)
- Hanci, Deniz(5)
- Karakoyun, Suleyman(5)
- Pehlivanoglu, Meltem Kurt(5)
- Terzi, Rabia(5)
- Zonp, Zeynep(5)
- Ahi, Emine Dundar(4)
- Akbulut, Yasin(4)
- Altun, Huseyin(4)
- Altun, Hüseyin(4)
- Baytugan, Nart Zafer(4)
Yayınlar
- Derleme MakaleAçık Erişim2026Scopus SJRQ2The Impact of Upper Extremity Rehabilitation on Fatigue in Individuals With Multiple Sclerosis: A Systematic Review
Şekercan, Gizem; Akbaş, Ecem Karanfil; Salcı, Yeliz
Background: Although numerous interventions have been investigated to alleviate fatigue in people with multiple sclerosis (PwMS), evidence regarding the effects of upper extremity rehabilitation on fatigue remains limited. Objective: The objective of this review was to evaluate and synthesize the available evidence on the effects of upper extremity rehabilitation interventions on fatigue in PwMS. Methods: This review was conducted in accordance with the PRISMA guidelines and was prospectively registered in the PROSPERO database. A systematic search of PubMed, Web of Science, and Scopus was performed up to August 2026. Studies were eligible if they investigated the effects of upper extremity rehabilitation interventions on fatigue in PwMS. The risk of bias of randomized controlled trials was assessed using the Risk of Bias 2 (RoB 2), and the certainty of the evidence was appraised using the GRADE methodology. Results: Nine studies including 250 participants (136 intervention, 114 control) met the inclusion criteria. The included studies evaluated a range of technology-assisted, exercise-based, home-based, and task-oriented upper extremity rehabilitation approaches, with some interventions incorporating more than one therapeutic or technological component. Fatigue outcomes were measured using the Fatigue Severity Scale (FSS) and the Modified Fatigue Impact Scale (MFIS). Risk of bias was low in three randomized controlled trials, with some concerns in two and high in two; among the two crossover studies, one was rated as low risk and one as high risk. GRADE assessment showed low certainty of evidence for studies using the FSS and very low certainty for those using the MFIS, indicating an overall low certainty of the available evidence. Conclusions: The available evidence is insufficient to draw definitive conclusions regarding the effects of upper extremity rehabilitation on fatigue in PwMS. Further high-quality randomized controlled trials are required.
- MakaleAçık Erişim2026Scopus SJRQ1Attitudes and behaviors toward hypnosis and hypnotic susceptibility in physiotherapy patients: a cross-sectional study
Kuculmez, Ozlem; Dundar Ahi, Emine; Ozbek, Ilhan Celil; Afsar, Sevgi Ikbali
Background and objectives: Hypnosis is a focused cognitive state with increased suggestibility and neurophysiological changes, but misconceptions remain despite its clinical value. This study examined physiotherapy patients' beliefs and behaviors about hypnosis, their hypnotic suggestibility levels, and the relationships among these factors. Materials and methods: This cross-sectional study included voluntary adult participants aged 18–70 years who presented to the physical medicine and rehabilitation outpatient clinics. Individuals with psychiatric disorders, cognitive impairment, poor general health, illiteracy, or incomplete data were excluded. Demographic characteristics were recorded, and participants were asked to complete the attitudes and beliefs toward hypnosis scale (VSABTH-T) and the Short Form of the Suggestibility Scale (SSS). The study evaluated participants' attitudes, beliefs, and levels of suggestibility, as well as the relationships among these variables. A significance level of p < 0.05 was accepted for all statistical analyses. Results: The study analyzed data from 399 participants (65.9% male, 34.1% female) with a mean age of 42.68 ± 16.75 years. 75.4% of participants had limited knowledge, and 3.5% had hypnosis experience. Predominantly expressed concerns regarding hypnotic procedures were 86.2% fear, 61.9% emerging from hypnosis, 51.8% losing control, and 33.3% of the participants defined hypnosis as dangerous. Participants had a mean attitude and behavior score toward hypnosis of 107.21 ± 15.8 and a mean hypnotizability score of 53.29 ± 8.76. Although age, occupation, and income level showed very weak but statistically significant correlations with the total VSABTH-T scores (p = 0.001), there was no correlation with total SSS scores (p > 0.05). Attitudes toward hypnosis and hypnotic suggestibility are significantly affected by age, education, occupation, income, and particularly the level of knowledge about hypnosis (p < 0.05). Total VSABTH-T and SSS scores were not correlated (p = 0.069), although very weak associations were observed between subdimensions (p < 0.05). Conclusion: Physiotherapy patients demonstrated limited hypnosis knowledge and experience and misconceptions. Demographic factors showed weak associations with attitudes and suggestibility. Findings highlight that personal beliefs and demographics interact complexly in shaping hypnotic responsiveness, emphasizing the need for targeted education to reduce misconceptions.
- MakaleYalnız künye2026Scopus SJRQ1Impact of guideline-based prompting on the large language model performance in dental trauma management clinical decision-making
Kaşıkçı, Sena; Şirinoğlu, Ebru; Özdemir, Olcay
This study evaluated the impact of guideline-based prompting on the performance of large language models (LLMs) in answering dental trauma–related questions. Sixteen multiple-choice questions (MCQs) and sixteen open-ended questions (OEQs) derived from the International Association of Dental Traumatology (IADT) guidelines were used. ChatGPT-4o, Gemini-2.5 Flash, and DeepSeek v3.2 were tested under two conditions: with and without guideline support. Questions were asked three times daily over three consecutive days using independent chat sessions. In the guideline-based condition, the dental trauma guideline was uploaded and models were instructed to answer according to the document. Responses were evaluated using predefined answer keys and a structured rubric. Statistical analyses were performed using the Shapiro–Wilk test, aligned rank transform (ART) analysis, and Bonferroni-adjusted multiple comparisons. Multiple-choice performance was consistently high across all models, with no significant effects of day, time, or AI model. Guideline-based prompting substantially improved performance and guideline concordance on open-ended questions. In the guideline-supported condition, DeepSeek achieved a median score of 32, while ChatGPT and Gemini achieved median scores of 30. Without guideline support, median scores decreased to 26, 20, and 23, respectively. All models achieved 100% accuracy on MCQs with guideline support, whereas accuracy ranged from 81.2% to 100% without guideline support. Significant differences between AI models were observed for OEQ scores (p < 0.001). Guideline-based prompting improved guideline concordance and overall performance, particularly for open-ended dental trauma questions. These findings support the use of guideline grounding to enhance the guideline concordance and reliability of LLM-generated responses while emphasizing the continued need for clinician oversight.
- MakaleAçık Erişim2026Scopus SJRQ1Differences in care burden, burnout, depression, quality of life and sleep quality between family members and professional caregivers of palliative care patients
Aydoğdu, Onur; Tetik-Aydoğdu, Yağmur; Oruç, Özlem; Alptekin, H. Kerem
Background: The main aim of our study was to investigate whether there are differences in caregiver burden, burnout, depression, sleep quality and quality of life between family members and professional caregivers of palliative care patients. Furthermore, we examined the impact of burnout, depression, and sleep quality on the burden of care among primary caregivers of palliative care patients. Additionally, we investigated whether there were differences in these parameters among family members according to gender. Methods: This cross-sectional study involved a total of 134 individuals, including 67 palliative patients receiving care from the Palliative Care Service and 67 caregivers who provide primary care to these individuals. The outcome measurements for palliative care patients included falls efficacy, functional independence, quality of life, and cognitive function. For caregivers, the following variables were measured: caregiving burden, burnout, depression, sleep quality, and quality of life. Results: This study found that family members may experience a higher level of care burden, burnout, depression, sleep difficulties and lower quality of life compared to professional caregivers (p < 0.05). In addition, female family members exhibited worse scores for care burden, sleep quality and quality of life than male family members (p < 0.05). Increased caregiver burden in palliative care patients was associated with increased levels of burnout and depression, as well as sleep disturbance and reduced quality of life (p < 0.05). Conclusions: Our study suggests that providing primary caregivers of palliative care patients with support tailored to their specific needs in terms of burnout, care burden, depression, sleep and quality of life could be an important palliative care service.
- MakaleYalnız künye2026Scopus SJRQ2Synthesis, biological evaluation, and computational analysis of chromone-based carboxamides targeting Alzheimer’s disease
Kilic, Burcu; Aksakal, Fatma; Dogruer, Deniz S.
Alzheimer's disease (AD) is among the most serious long-term health problems of the last few decades. Regrettably, the current lack of treatment options for AD has made it a highly sought-after topic of drug development research. The utilization of multitarget directed ligand design (MTDL) has been the primary focus of research on developing pharmaceuticals for AD. By this approach, we designed novel cholinesterase inhibitors (ChEI) that may also exhibit additional monoamine oxidase (MAO) inhibitory, antioxidant, and metal chelator properties. Within the scope of the current work, twenty N-(2-(tertiaryamine-substituted)ethyl)-4-oxo-4H-chromene-2/3-carboxamide derivatives were synthesized and characterized. Subsequently, we conducted biological investigations for enzyme inhibitory (ChEs and MAO), antioxidant, and metal-chelating activities. Furthermore, we assessed the in silico physicochemical parameters of the compounds to evaluate their drug-likeness or druggability. Additionally, comprehensive computational studies were conducted, including density functional theory (DFT)-based frontier molecular orbital (FMO) analysis, global chemical reactivity descriptors, and molecular electrostatic potential (MEP) surface analysis, along with molecular docking, to elucidate the electronic properties, reactive sites, and binding interactions of the compounds with ChE enzymes.
- MakaleAçık Erişim2026Scopus SJRQ2Cardiorespiratory adaptations to high-intensity interval training in young boxers: A randomized controlled study
Cinarli, Sena; Akyol, Betül; Karakurt, Fatih; Mutlu, Koray; Tutar, Muammer; Cinarli, Fahri Safa; Aldhahi, Monira I.
Background: – High-intensity interval training (HIIT) has been recognized for its effectiveness in enhancing cardiorespiratory fitness. However, the application of HIIT within boxing training remains underexplored. This study aimed to investigate the physiological adaptations induced by a structured 4-week HIIT-boxing regimen, with a specific focus on pulmonary function (PF), aerobic capacity, and autonomic cardiovascular regulation, assessed by heart rate recovery (HRR). Methods: – Sixteen trained young individuals were randomly assigned to either the HIIT-boxing group or the control group. Comprehensive assessments, including PF tests, peak oxygen uptake, and HRR at the 1st, 3rd, and 5th minutes postexercise, were conducted pre- and post-intervention. Results: – Significant improvements were observed in maximal voluntary ventilation, forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and peak expiratory flow over time (P < .01), while the FEV1/FVC ratio remained unchanged (P = .244). Time-by-group interactions revealed greater improvements in maximal voluntary ventilation (ηp2 = 0.817), FVC (ηp2 = 0.618), and FEV1 (ηp2 = 0.283) in the HIIT group than in the control group. Although estimated estimated maximal oxygen uptake improved significantly over time (P < .001), no significant group effect or time-by-group interaction was observed. HRR improved significantly over time in both groups (P < .001), with no significant time-by-group interaction observed at any measured interval (P > .05). Conclusion: – Supplementing conventional boxing training with HIIT may serve as a useful strategy for enhancing selected PF parameters in combat sports athletes. However, because the HIIT group performed a greater total training volume, the observed improvements cannot be definitively attributed to HIIT independently of the increased training stimulus.
- MakaleAçık Erişim2026Scopus SJRQ3Effect of psychiatric nurses' counseling on exercise behavior in individuals diagnosed with psychiatric disorders: A transtheoretical model-based randomized controlled trial
Yalçın, Suna Uysal; Bilgin, Hülya
Objectives: Insufficient physical activity, which is one of the unhealthy lifestyle behaviors, is more common in individuals diagnosed with psychiatric disorders. This experimental study aimed to examine the effect of psychiatric nurses’ counseling role on improving exercise behavior in individuals diagnosed with psychiatric disorders through the TTM framework. Methods: This randomized controlled trial, with pretest, posttest, and follow-up assessments, included 61 patients from a community mental health center (intervention, n=30; control, n=31). The study data were collected using the “Information Form”, “Exercise Change Stages Scale”, “Exercise Processes of Change Scale”, “Exercise Self-Efficacy Scale”, and “Exercise Decisional Balance Scale”. Results: The proportion of participants in the "preparation" phase after the intervention increased (n=15, 48.4%) in the intervention group, while the rate of participants in the "preparation" phase remained the same in the control group (n=8, 26.7%). The intervention group showed increases in the “Exercise Self-Efficacy Scale” and “Exercise Decisional Balance Scale” pros scores from baseline to post-intervention, with these gains persisting at follow-up. As a result, it was observed that the counseling role of psychiatric nurses through the Transtheoretical Model was effective in improving exercise behavior and physical health conditions of individuals diagnosed with psychiatric disorders. Conclusion: The counseling role of psychiatric nurses based on the Transtheoretical Model has been found to be effective in improving exercise behavior among individuals diagnosed with psychiatric disorders, thereby reducing risks associated with physical illnesses. Additionally, the findings suggest that Transtheoretical Model-based counseling can be effectively utilized in the independent practices of psychiatric nurses, thereby strengthening their counseling role.
- Derleme MakaleAçık Erişim2026Scopus SJRQ1Awareness and Educational Effectiveness of the ToothSOS Mobile Application for Traumatic Dental Injuries: A Systematic Review and Meta-Analysis
Aykanat, Berkehan; Ayhan, Muhammed; Özyürek, Hande; Ayaz, Bilal
Background/Aim: ToothSOS is a free International Association of Dental Traumatology application giving guideline-based first-aid instructions for traumatic dental injuries; no synthesis specific to it exists. This review assessed awareness of the application, its educational effectiveness and its reported quality and utilisation. Material and Methods: PubMed, Scopus, Web of Science and Google Scholar, with supplementary sources, were searched on 5 August 2026 without language or date restrictions. Studies addressing any of these were eligible. With one conflict-of-interest exception, screening, extraction and appraisal were independent and in duplicate, using Joanna Briggs Institute checklists and a review-specific appraisal. Awareness was pooled using a binomial–normal generalised linear mixed model with a prespecified subgroup analysis by population type. Certainty was assessed with the Grading of Recommendations Assessment, Development and Evaluation approach. Results: Twenty-one studies were included. Fourteen awareness studies included 4576 participants; eight were conducted in Türkiye. Awareness was 27.1% (95% confidence interval 13.4–47.1) among dental professionals and students, 3.1% (1.0–8.8) among non-dental health professionals and students and 1.6% (0.6–4.1) among lay populations. Pooled across all populations it was 5.0% (1.8–13.1), with substantial heterogeneity (I2 = 96.5%) and a prediction interval of 0.1%–79.2%; this summarises the included samples rather than any global population. Three uncontrolled studies (298 participants) reported immediate knowledge gains too heterogeneous to pool; at 1 month their pooled standardised mean change was 2.33 (1.48–3.18). Certainty was very low for awareness and educational outcomes. Conclusions: Awareness was particularly low in non-dental health and lay samples. Population and geographic heterogeneity limit generalisation. Short-term knowledge gains do not establish sustained learning or improved management of actual injuries, and application-quality findings rest on an unvalidated review-specific appraisal. These findings support evaluating targeted dissemination and longer-term clinical outcomes. Trial Registration: PROSPERO; submitted 28 July 2026 and formally registered 9 August 2026, after the searches.
- MakaleYalnız künye2026Scopus SJRQ1Artificial intelligence–assisted scenario development for simulation-based pediatric forensic case training: A qualitative study of paramedic students’ experiences
Akkol, Sefa; Erdoğan, Birgül; Arslan, Canan; Bağlioğlu, Nihal; Hurma, Aykut
Background: This study aimed to explore first-year paramedic students’ perceptions, emotions, and experiences related to scene management in pediatric forensic cases and to examine their experiences following a simulation training module developed with artificial intelligence–assisted scenario development. Methods: This qualitative study was conducted using a phenomenological approach. Data were collected through individual and focus group interviews conducted before and after the simulation training intervention Results: Following the training, students reported perceived improvements in clinical self-confidence, professionalism, awareness of evidence preservation, ethical sensitivity, and adoption of a child-centered approach. Conclusion: Simulation-based pediatric forensic training incorporating AI-assisted scenario development may support students’ professional awareness, forensic reasoning, and decision-making processes.
- MakaleAçık Erişim2026Scopus SJRQ2An Examination of the Impact of Healthy Lifestyle Behaviours and Self-Neglect on e-Health Literacy Among Older Adults Using Path Analysis
Ertürk, Özge; Çetin, Kübra; Azak, Şeyma Nur; Efetürk, Nida
AIM: This study aimed to examine the effects of healthy lifestyle behaviours and self-neglect on eHealth literacy among individuals aged 60 years and older, and to explore the structural relationships between these variables using path analysis. METHODS: This cross-sectional and descriptive study was conducted with 251 older adults living in Türkiye. Data were collected using a Personal Information Form, the Healthy Lifestyle Behaviours Scale II, the Self-Neglect Scale in Older Adults, and the eHealth Literacy Scale via an online survey. Direct and indirect relationships among variables were analysed using Structural Equation Modelling. RESULTS: The mean age of participants was 68.22 ± 9.24 years. Healthy lifestyle behaviours were positively associated with eHealth literacy (β = 0.423, p < 0.001), whereas eHealth literacy was negatively associated with self-neglect (β = -0.300, p < 0.001). The direct association between healthy lifestyle behaviours and self-neglect was not statistically significant (β = -0.053, p = 0.463), while the indirect association through eHealth literacy was significant (β = -0.127, p < 0.001). The model showed mixed fit, with χ2/df, CFI, TLI, and SRMR meeting the prespecified acceptable-fit criteria, whereas RMSEA remained above the specified threshold. CONCLUSION: The findings indicate that healthy lifestyle behaviours are associated with reduced self-neglect only when supported by higher levels of eHealth literacy. Integrating structured interventions to improve eHealth literacy alongside promoting healthy lifestyle behaviours may enhance the effectiveness of strategies targeting self-neglect in older adults.
- Derleme MakaleYalnız künye2026Scopus SJRQ2Effectiveness of Telerehabilitation Versus Conventional Rehabilitation on Motor Function and Activities of Daily Living After Stroke: A Systematic Review of Randomized Controlled Trials
Shehzadi, Kainat; Tătaru, Tiberiu
BackgroundAlthough telerehabilitation is an increasingly popular method for delivering physiotherapy remotely, its efficacy compared with traditional in person therapy for stroke patients remains uncertain.ObjectiveThis systematic review evaluates the effectiveness of telerehabilitation compared with conventional physiotherapy on motor function (Fugl-Meyer Assessment, FMA) and activities of daily living (Barthel Index) in stroke patients.ResultsFour trials involving 226 randomized participants were included. Cramer et al. showed noninferiority of dose-matched home telerehabilitation for Fugl-Meyer change (adjusted difference 0.06 points, 95% CI -2.14 to 2.26; p = .96). Shamweel and Gupta found no post-treatment FMA-UE difference (p = .337). Saygili et al. reported significant group-by-time interactions for FM-UE (p = .001) and FIM (p = .006), but Tele-CIMT was added to a home-exercise program and was not dose matched. Chen et al. found no differential Modified Barthel Index trajectory (group-by-time p = .897). Two trials were judged low risk of bias and two had some concerns. Certainty was very low for motor and ADL outcomes because of inconsistency, indirectness, and imprecision, with additional risk-of-bias concerns.ConclusionsTelerehabilitation can produce clinically relevant gains, and one adequately powered dose-matched trial supports noninferiority for arm motor recovery. The evidence does not establish general superiority over equivalent in-person rehabilitation. Larger trials should match content and dose, prespecify comparative estimands, and report standardized outcomes.
- MakaleAçık Erişim2026Scopus SJRQ3Investigation of evidence-based practices of nurses in a rural public hospital: a mixed methods study
Ziyai, Nasibe Yagmur; Sener, Senay; Dikmen, Yurdanur
Background: Evidence-based practice was essential for ensuring high-quality patient care, improving safety, and reducing healthcare costs. As the largest group of healthcare providers, nurses played a pivotal role in implementing evidence-based practice. However, they often encountered multiple personal and organizational barriers, particularly in rural settings characterized by limited resources and geographic isolation. Aim: This study aimed to comprehensively examine nurses’ attitudes toward evidence-based nursing in a rural public hospital and to assess how these attitudes influenced clinical care practices. Methods: An explanatory sequential mixed-methods design was employed. Quantitative data were collected from 86 nurses using a Nurse Information Form and the Scale of Attitudes Toward Evidence-Based Nursing. Qualitative data were obtained through three mini–focus group interviews with nine nurses purposefully selected based on variations in their evidence-based practice attitudes and professional characteristics. Descriptive statistics, one-way ANOVA, LSD post hoc tests, and thematic analysis were used to analyze the data. Results: The mean attitude score was 58.09 ± 9.17, with significantly higher scores among nurses with 1–10 years of professional experience. Thematic analysis revealed three overarching themes: facilitators, barriers, and suggestions. Facilitators included peer collaboration, innovation, nursing professionalism, and improved quality of patient care. Barriers comprised patient reactions, professional challenges, organizational limitations, insufficient knowledge, and workplace conflicts. Nurses’ recommendations emphasized enhancing patient and nurse education, fostering a culture of discussion, updating clinical guidelines, and strengthening shared decision-making mechanisms. Conclusion: Although nurses demonstrated generally positive attitudes toward evidence-based practice, they encountered substantial challenges in applying it in clinical settings. Establishing structured support systems, leadership training, and policy-level interventions is essential to foster effective and sustainable implementation of evidence-based practice in rural hospitals.
- MakaleYalnız künye2026Scopus SJRQ4Radiologic-anatomical correlation of sphenoid sinus and sella turcica variations
Medişoğlu, Mahmut S.; Öçbe, Melisa; Genç, Mediha Gülden
The sphenoid sinus displays variable pneumatization patterns and complex morphology, situated near vital vascular and neural structures. Understanding its anatomical variations is essential for accurate radiological diagnosis and safe surgical planning in otolaryngology and neurosurgery. Different pneumatization types may influence surgical outcomes and complication risks. This retrospective study analyzed 408 CT scans from patients aged ≥18 years to assess sphenoid sinus pneumatization and morphometry. Pneumatization types were classified as conchal, presellar, incomplete sellar, and complete sellar. Morphometric parameters (width, height, and angle) were measured on sagittal CT images. Intraobserver reliability showed excellent agreement. Statistical analyses included descriptive statistics, ANOVA, t-tests, Pearson correlation, and Chi-square tests. Incomplete (41.42%) and complete sellar (40.44%) were the most frequent pneumatization types. Males had greater posterior wall width (p = 0.0008), and age positively correlated with width (p = 0.0125), height (p < 0.0001), and angle (p = 0.0068). Pneumatization types differed significantly by gender (p = 0.0439). Posterior wall height varied significantly across sphenoid sinus pathologies (p = 0.0024), with higher values in cases of polypoid tissue and cysts. Significant correlations existed between width and height (p = 0.0251), and width and angle (p = 0.0053). Incomplete sellar pneumatization was most common, with notable gender differences in type prevalence. While sellar morphometry correlated with age and gender, it was not associated with pneumatization types. Variations in posterior wall height across sinus pathologies may reflect anatomical variability, showing the importance of detailed imaging evaluation.
- MakaleAçık Erişim2026Scopus SJRQ1Evaluation of the frequency, risk factors and outcomes of ROP in preterm infants with a BW >1500 g or GA >32 weeks in Turkiye (TR-ROP 2) and medicolegal fears: a Turkish Neonatal Society multicentre study
Bas, Ahmet Yagmur; Koc, Esin; Unal, Sezin; Hirfanoglu, Ibrahim Murat; Arslan, Zehra; Gundogdu, Semra; Iyigun, Fatma; Kale, Yusuf; Tanrıverdi, Sema; Mutlu, Birgul
Background This study aimed to evaluate the prevalence and risk factors of retinopathy of prematurity (ROP) in preterm infants with a birth weight (BW)>1500 g or gestational age (GA) >32 weeks in Turkiye. Methods A prospective cohort study (TR-ROP 2) was conducted in 80 neonatal intensive care units between 30 September 2023 and 1 November 2024. Infants with a BW >1500 g or GA >32 weeks who had an unstable clinical course or were deemed at risk for ROP were included. The effect of medicolegal concerns on the decision to screen was also evaluated. Results The study included 4140 infants at risk for ROP development; 242 (5.8%) developed any stage of ROP, and 17 (0.4%) developed severe ROP requiring treatment. Risk factors independently associated with ROP included lower GA and BW, being small for GA, red blood cell transfusion, oxygen therapy >5 days, mechanical ventilation >1 day, early neonatal sepsis (ENS) with comorbidities or presence of ≥3 comorbidities (excluding ENS). Of those with BW ≥2000 g, 31.4% were screened for medicolegal reasons; 2.2% developed ROP, but none had severe ROP. Conclusions ROP in mature infants is rare but can occur in the presence of multiple risk factors. Medicolegal concerns may contribute to overscreening. Developing evidence-based, risk-adapted screening guidelines is essential to ensure appropriate care without unnecessary interventions.
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İncele - MakaleAçık Erişim2026Scopus SJRQ1Comparison of safety and short-term outcomes of septostomy and direct tunnel passage techniques in percutaneous patent foramen ovale closure: a multicenter experience
Coskun, Senol; Tiryakioğlu, Selma Kenar; Mirzamidinov, Didar; Inan, Duygu; Kilicgedik, Alev; Sahin, Tayfun; Kilic, Teoman
Background – Percutaneous closure of a patent foramen ovale (PFO) is an established therapeutic strategy for patients with cryptogenic stroke (CS). This study aimed to compare the procedural safety, efficacy, and short-term clinical outcomes of atrial septostomy vs. standard direct tunnel passage techniques for PFO closure. Methods – We retrospectively analyzed consecutive patients who underwent PFO closure for CS at four centers between January 2010 and December 2020. Demographic characteristics, vascular risk factors, Risk of Paradoxical Embolism (RoPE) scores, PFO anatomical features, procedural details, and clinical outcomes were compared between patients treated with atrial septostomy and those undergoing direct tunnel passage. Continuous variables are presented as mean ± standard deviation or median [interquartile range], and categorical variables as counts and percentages. Results – A total of 246 patients were included (mean age 40.5 ± 9.8 years), of whom 69.9% presented with ischemic stroke and 30.1% with transient ischemic attack (TIA). Atrial septostomy was performed in 106 patients (43.1%), while 140 patients (56.9%) underwent direct tunnel passage. Baseline clinical characteristics were comparable between groups; however, the septostomy group exhibited significantly more complex PFO anatomy, including atrial septal aneurysm (69.8% vs. 39.3%), septal hypermobility (62.3% vs. 34.3%), and spontaneous shunting at rest (85.8% vs. 50.7%; all p < 0.001). Procedure duration was similar between groups (41.1 ± 10.2 vs. 40.7 ± 13.8 min; p = 0.83), and technical success was achieved in nearly all cases. No major procedural complications occurred. Minor adverse events were infrequent and comparable (8.4% vs. 4.3%; p = 0.20). At six-month follow-up, residual shunt rates were numerically lower in the septostomy group (6.6% vs. 11.4%; p = 0.27). No TIAs were observed in the septostomy group, whereas a 3.6% incidence was noted in the direct passage group (p = 0.08). New-onset atrial arrhythmia occurred in two patients (1.9%) in the septostomy group and in none of the direct passage group (p = 0.18). Conclusion – Despite being applied in patients with more complex PFO anatomy, atrial septostomy demonstrated comparable procedural safety, technical success, and short-term efficacy to standard direct tunnel passage. Tunnel length emerged as an independent predictor of residual shunt, regardless of closure technique. In experienced centers, atrial septostomy appears to be a safe and practical alternative for anatomically challenging PFO closures.
- MakaleAçık Erişim2026Scopus SJRQ1Evaluation of Dental Trauma Knowledge and ToothSOS Application Awareness Among Emergency Physicians
Aykanat, Berkehan; Özyürek, Hande; Sezer, Meryem Çoban; Ayaz, Bilal; Bayar, Ayşe Elif; Keskin, Etkin; Özyürek, Taha
Background/Aim: Emergency physicians are among the first healthcare professionals to manage traumatic dental injuries, yet knowledge deficiencies may compromise early care. This study evaluated emergency physicians' knowledge of traumatic dental injury management, ToothSOS awareness, and factors independently associated with overall knowledge. Materials and Methods: This questionnaire-based cross-sectional study was conducted among emergency physicians in Turkey between April 2 and May 19, 2026. The survey assessed demographic and professional characteristics, traumatic dental injury knowledge, ToothSOS awareness, and willingness to use the application. Item-level associations were analyzed using chi-squared or Fisher's exact tests. An overall knowledge score, ranging from 0 to 8, was analyzed using univariable comparisons and multivariable linear regression. Factors associated with willingness to use ToothSOS were evaluated using multivariable logistic regression. Results: A total of 208 emergency physicians were included. Correct-response rates ranged from 47.1% for the first intervention for an avulsed permanent tooth to 91.8% for identifying the most commonly affected teeth. ToothSOS awareness was 1.0%, although 79.6% of unaware participants stated they would consider using the application. The mean overall knowledge score was 5.23 ± 1.48. Previous dental trauma training and clinical exposure to traumatic dental injury cases were associated with higher scores in univariable analyses; only clinical exposure remained an independent predictor after adjustment. No factor independently predicted willingness to use ToothSOS. Conclusions: Emergency physicians demonstrated moderate overall traumatic dental injury knowledge, with deficiencies in avulsion management and referral decisions. Previous clinical exposure to such cases was the only independent predictor of higher knowledge scores, supporting structured training rather than reliance on incidental experience. Low ToothSOS awareness, despite high willingness to use it, supports integrating dental trauma education and digital decision-support tools into emergency medicine training and clinical protocols.
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İncele - MakaleYalnız künye2026Scopus SJRQ1Psychometric Evaluation of Barriers to Help-Seeking-Trauma Scale in Turkish Violence Survivors
Zonp, Zeynep; Ergun, Gul; Uysal Yalcin, Suna; Simsek Arslan, Buket; Koyuncu, Ilhan; Saint Arnault, Denise
Gender-based violence (GBV) is a significant global public health and human rights issue. Despite experiencing violence, many survivors hesitate to seek professional help due to individual, social, and cultural barriers. Understanding these barriers is essential for improving access to support services. The Barriers to Help-Seeking–Trauma Version (BHS-TR) Scale was developed to identify such barriers across different cultural contexts. This study aimed to culturally adapt the BHS-TR Scale into Turkish and evaluate its psychometric properties in a sample of GBV survivors. A cultural adaptation and cross-sectional psychometric study was conducted between May and August 2024 at two universities in Türkiye. The sample included 163 women students who reported experiences of GBV. Data were collected using a demographic form, the Turkish version of the BHS-TR Scale, and the Barriers to Seeking Mental Health Counseling Scale (BMHC). Statistical analyses were conducted using SPSS 21, Jamovi, and JASP. Descriptive statistics, confirmatory factor analysis (CFA), reliability testing (Cronbach’s alpha and McDonald’s omega), and convergent validity assessment were performed. Participants most reported psychological violence (88.3%), coercion and threats (31.3%), childhood abuse (25.8%); 61.3% had never sought professional help. CFA supported the seven-factor structure of the BHS-TR Scale. Internal consistency was high (Cronbach’s α =.934). BHS-TR scores showed a moderate-positive correlation with the BMHC (r =.312, p <.01), supporting convergent validity. The Turkish BHS-TR Scale is a valid and reliable tool to assess help-seeking barriers among GBV survivors. It offers culturally relevant measures for research, policy, and intervention planning.
- MakaleYalnız künye2026Scopus SJRQ2Relationship of kinesiophobia with pain, disability, and lumbar multifidus muscle morphology in chronic mechanical low back pain: an ultrasonographic cross-sectional study
Özbek, İlhan Celil; Gulcelik, Gonul Ertunc; Ünlü, Zeliha; Tıkız, Canan; Özduran, Erkan
Background: Chronic mechanical low back pain (CMLBP) cannot be explained by biomechanical factors alone; psychosocial factors such as kinesiophobia may also relate to structural changes in trunk-stabilizing muscles. Ultrasonography enables objective assessment of lumbar multifidus morphology (anteroposterior [AP] thickness and cross-sectional area [CSA]). Aims: To investigate the relationship between kinesiophobia and lumbar multifidus morphology among those with CMLBP, and to determine whether this relationship is independent of pain intensity, disability, and demographic/anthropometric factors. Methods: In this cross-sectional study, 100 patients with CMLBP (≥3 months) were assessed using the Visual Analog Scale (VAS), Oswestry Disability Index (ODI), and Tampa Scale of Kinesiophobia (TSK; low <37, high ≥37). Bilateral multifidus AP thickness and CSA were measured ultrasonographically at L4–L5. Group comparisons, correlation, partial correlation, and regression analyses were performed. Results: Mean age was 49.8 ± 12.6 years (68% female); 65% had high kinesiophobia, more frequent among women (76.9% vs. 51.4%, p =.017). The high-TSK group showed higher VAS (6.68 ± 1.98 vs. 5.03 ± 1.71, d = 0.87) and ODI (35.12 ± 15.23 vs. 24.46 ± 11.47, d = 0.76), and smaller multifidus AP thickness and CSA (d = 0.48–0.62). Kinesiophobia scores correlated positively with VAS (r = 0.53) and ODI (r = 0.64), and negatively with multifidus thickness/CSA (r = −0.24 to −0.41). After adjusting for VAS and ODI, the TSK–CSA correlation was markedly attenuated and lost significance (partial r = −0.13 to −0.18, p >.05); after adjusting for age, sex, and BMI, it remained significant (partial r = −0.36 to −0.40, p <.001). Regression confirmed VAS and ODI, but not CSA, as independent predictors of TSK. Conclusions: High kinesiophobia is associated with greater pain, disability, and reduced multifidus morphology among those with CMLBP. However, this morphological association appears largely mediated by pain and disability rather than being independent of them, while remaining unrelated to demographic/anthropometric confounding. These cross-sectional findings support a biopsychosocial framework and warrant longitudinal confirmation.
- MakaleYalnız künye2026Scopus SJRQ3Synthesis of β-Lactam Conjugates of Thiadiazine Thiones as a New Class of Anti-Nociceptive Agents
Mohsin, Abdul Haseeb; Torlak, Yasemin; Altuner, Elif Esra; Aldemir, Ozan; Khan, Rasool; Issa, Ghassan; Zafar, Salman; Bibi, Aiman; Khan, Misbah Rafiq; Khan, Huma
A series of newly synthesized β-lactam conjugates of thiadiazine-2-thiones (TDZ-2T) were prepared by reacting various primary amines with carbon disulfide and potassium hydroxide, followed by the addition of formaldehyde and β-lactam antibiotics, including cefaclor and cefadroxil, in phosphate buffer. The synthesized substances were evaluated for their in vitro antimicrobial activity against P. aeruginosa and E. coli. All the substances exhibited activity against each forms of bacterial types, with 1e, 1f, 1g, 2a, and 2b showing the most significant activity. Additionally, the anti-nociceptive impact of the prepared substances was analyzed by the hot plate technique. Substances 1a, 1b, 1d, 1f, 1g, and 2a demonstrated notable activity at dosages of 80 mg/kg, as evidenced by a significant enhancement during the lag phase. Intact binding studies of the synthesized substance were also performed and showed a good binding interaction with the binding site of the in silico cyclooxygenase-2 (COX) enzyme.
AtıfScopus1OpenAlex1İncele - MakaleAçık Erişim2026Scopus SJRQ4Relationship between individuals’ stigmatizing attitudes towards abortion, family planning attitudes, and fatalism in health: a cross-sectional study
Gökçay, Gönül; Efetürk, Nida; Çevirme, Ayşe
Background. Abortion regulations and associated social stigma in Türkiye significantly inf luence access to reproductive health services and decision-making. Societal beliefs in fatalism and religious inf luences further shape healthcare utilization, contributing to increased risky behaviors and reluctance to seek treatment. Material and methods. This study investigates the relationship between stigmatizing attitudes towards abortion, attitudes towards family planning, and religious health fatalism. Designed as a descriptive and correlational study, it included 1,495 participants aged 18 and older. Data were analyzed using SPSS 27-V. Results. The participants exhibited moderate levels of stigmatizing attitudes towards abortion and health-related fatalism and high levels of positive attitudes towards family planning. Pearson correlation analysis revealed a moderate negative relationship between stigmatizing attitudes towards abortion and attitudes towards family planning, alongside a moderate positive relationship between stigmatizing attitudes towards abortion and health-related fatalism. Conclusions. The findings highlight that opposition to abortion negatively impacts attitudes towards family planning, with religious beliefs and fatalistic views significantly shaping these attitudes. Community awareness programs addressing stigma around abortion and family planning can enhance service accessibility. Moreover, culturally sensitive counseling and educational initiatives addressing the influence of religious and fatalistic beliefs could foster a better understanding of reproductive health, improving health outcomes within society.
