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MakaleAçık Erişim2025Scopus SJRQ2/r/kostu/10690
Nursing Students Perception and Frequency of Incıvılıty in Nursing Education: A Descriptive Correlational Study
Gözütok Konuk, Tuğba; Kurşun Kural, Şerife; Dikmen, Yurdanur
Background: Nursing students are exposed to incivility in both classroom and clinical practice settings during their education. Due to its ambiguous nature and different perceptions of incivility, it can sometimes be ignored. Aim: This study aimed to determine nursing students' perception and the frequency of faculty incivility and its predictors. Methods: The study has a descriptive-correlational design. The study was conducted with 346 second and third-year students. Data were collected using the Student Demographic Information Form, the Rosenberg Self Esteem Scale, and the Incivility in Nursing Education Revised. Results: The students' mean total score for perceived faculty incivility was 3.37 ± 0.46, while the mean total score for incivility frequency based on exposure to faculty behaviors was 1.69 ± 0.43. Conclusion: It is anticipated that the results of this study, by raising awareness of the current situation in terms of faculty incivility perception and frequency, will be useful in developing procedures for preventing incivility and promoting a culture of civility among faculty members.
AtıfScopus2WoS2OpenAlex2
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MakaleAçık Erişim2025Scopus SJRQ1/r/kostu/10685
Virtual reality-based home accident control simulation combined with first aid training to enhance awareness in parents of children with special needs: protocol for a single-group pre-post quasi-experimental study
Ertunc Gulcelik, Gonul; Ortabag, Tulay; Yilmaz, Sila; Sever, Ebru; Eryigit, Tuba
Introduction Children with special needs frequently experience accidents and injuries due to motor control difficulties. The most common home accidents include falls, burns, poisoning, drowning and choking. Compared to their typically developing peers, children with special needs are at a higher risk of home accidents and emergency department visits. Falls related to balance impairments are especially common in this population. The aim of this study is to assess the effects of a virtual reality-based home accident control simulation combined with first aid training on the awareness and initial responses to home accidents of parents of children with special needs, using a single-group pre-post quasi-experimental design. Methods and analysis This quasi-experimental study, using a pre-test/post-test design, is planned to include 100 volunteer parents of children with special needs who are registered at a Barrier-Free Life Application and Research Centre. The parents will receive training on home accidents via virtual reality simulation, supplemented by first aid and transfer training. Data will be collected using the Descriptive Information Form and the Home Accident Awareness Questionnaire for Parents of Children with Special Needs. Children’s balance status will be assessed to determine their fall risk using the Children’s Balance Assessment Form, the Tinetti Balance and Gait Assessment and the Nintendo Wii Fit Balance Board. Ethics and dissemination Ethical approval was obtained from the Ethics Committee of Istanbul Topkapi University. The results will be disseminated through peer-reviewed journals and academic conferences.
AtıfScopus1WoS1OpenAlex1
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MakaleYalnız künye2025Scopus SJRQ1/r/kostu/10677
Is Abobotulinum A Superior to Onabotulinum A in Reducing Pain in Patients With Nocturnal Bruxism?
Asutay, Fatih; Asutay, Hilal; Acar, Ahmet Hüseyin
Background: Botulinum toxin has been used to treat myofascial pain and nocturnal bruxism. It remains unclear whether there is a difference in efficacy between different BTX subtypes. Purpose: The purpose of this study was to measure the changes in pain and maximum incisal opening in subjects with nocturnal bruxism who received either Abobotulinum A (ABA) or Onabotulinum A (OBA) and determine which is faster and longer-acting. Study Design, Setting, Sample: The researchers implemented a retrospective cohort study. Subjects presenting to Uzman Dentaclinic outpatient clinic in Bursa, Turkey, with nocturnal bruxism between June 2023 and June 2024 were identified from a review of the electronic medical record. Subjects with systemic diseases, taking active medications and undergoing psychotherapy were excluded from the study. Predictor Variable: The predictor variable was the treatment assigned to the subjects received either ABA or OBA injections. Main Outcome Variable(s): The primary outcome variable is therapeutic response as evidenced by changes in preoperative and postoperative pain score and maximum mouth opening. The secondary outcomes were the time to onset and duration of therapeutic response. Covariates: The covariates included demographics (age, sex) and preoperative (duration of complaint) variables. The postoperative covariates were postinjection discomforts and complications. Analyses: χ2 tests were used to analyze categorical data. Unpaired t-tests, Friedman test and Mann–Whitney U test were used to analyze continuous data. Results were considered significant at a P value of <.05. Results: The sample included 100 subjects with a mean age of 35.32 ± 9.11 years (OBA group, 33.78 ± 8.36 years; ABA group, 36.86 ± 9.64 years) (P = .09). There were 8 men (16%) and 42 women (84%) in the OBA group, and 10 men (20%) and 40 women (80%) in the ABA group (P = .6). There were no statistically significant differences between the groups in terms of visual analog scale scores and maximum mouth opening values at 2 weeks, 1 month, 3 months, 4 months, and 6 months (P ˃ .05). The ABA and OBA groups showed statistically significant differences in the onset of the treatment effect (11.18 ± 2.93 days [95% CI: 10.36 to 11.99] vs 8.69 ± 2.7 days [95% CI: 7.94 to 9.44]; P ˂ .05) and its duration (5.11 ± 1.19 months [95% CI: 4.78 to 5.43] vs 7.14 ± 1.71 months [95% CI: 6.66–7.61]; P ˂ .05). Conclusions: The ABA group demonstrated an earlier onset and longer duration of the treatment effect. However, both types of BTX-A products, which are commonly used in dental clinics, provided statistically significant outcomes in terms of pain and maximum mouth opening.
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Derleme MakaleYayıncıda açık erişim2025Scopus SJRQ1/r/kostu/10667
Current Applications, Challenges, and Future Directions of Artificial Intelligence in Emergency Medicine: A Narrative Review
Farrokh, Mehrdad; Fallahian, Amir H.; Rahmani, Erfan; Aghajan, Ali; Alipour, Morteza; Khouzani, Parisa Jafari; Hezarani, Hossein Boustani; Sabzehie, Hamed; Pirouzan, Mohammad; Pirouzan, Zahra
Artificial intelligence (AI) systems have witnessed notable advancements, revolutionizing various fields of research and medicine. Specifically, advancements of AI and the rapid growth of machine learning hold immense potential to significantly impact emergency medicine. This narrative review aimed to summarize AI applications in prehospital emergency care, emergency radiology, triage and patient classification, emergency diagnosis and interventions, pediatric emergency care, trauma care, outcome prediction, as well as the legal and ethical challenges and limitations of AI use in emergency medicine. A comprehensive literature search was conducted in Web of Science, Scopus, and Medline using a wide range of artificial intelligence and machine learning-related keywords combined with terms related to emergency medicine to identify relevant published studies. The findings show that AI-powered tools can assist clinicians in emergency departments in improving the management of prehospital emergency care, emergency radiology, triage, emergency department workflow, complex diagnoses, treatment, clinical decision-making, pediatric emergency care, trauma care, and the prediction of admissions, discharges, complications, and outcomes. However, the majority of these applications have been reported in retrospective studies, whereas randomized controlled trials (RCTs) are essential to determine the true value of AI in emergency settings. These applications can serve as effective tools in emergency departments when they are continuously supplied with high-quality real-time data and are adopted through collaboration between skilled data scientists and clinicians. Implementing these AI-assisted tools in emergency departments requires adequate infrastructure and machine learning operation systems. Since emergency medicine involves various clinical decision-making scenarios based on classifications, flowcharts, and well-structured approaches, future well-designed prospective studies are necessary to achieve the goal of replacing conventional methods with new AI and machine learning techniques.
AtıfScopus10WoS8OpenAlex5
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MakaleAçık Erişim2025Scopus SJRQ3/r/kostu/10663
Investigation of quaternary ammonium compound resistance in Staphylococcus aureus strains isolated from several foods and food production facilities
Bayrakal, G.M.; Aydin, A.; Issa, G.; Dumen, E.; Sudagidan, M.
Quaternary ammonium compounds (QACs) are the most significant disinfectants utilised to control the contamination of Staphylococcus aureus in food establishments. S. aureus is a significant pathogen that carries genes responsible for resistance to QACs, which pose a risk to public health and food safety. The objective of the study was to investigate the prevalence of QAC genes (qacA/B, qacC, qacG, qacH, qacJ, and smr) and benzalkonium minimal inhibitory concentration (MIC) values in S. aureus strains isolated from food products and food production facilities (n = 200). The analysis results indicated that the qacC gene was the most frequently detected, with a prevalence of 12%. The qacA/B, qacG, qacH, qacJ, and smr genes were identified at frequencies of 2%, 3%, 1%, 4.5%, and 5%, respectively. The highest MIC level was identified in the surface sample, which carried the qacG gene, at a concentration of 6.25 μg mL-1. The study's results highlight the potential risks associated with disinfectant resistance in food establishments. To prevent the transfer of disinfectant resistance genes, which have become a global risk, it is imperative that the rules of disinfectant usage are observed rigorously and that scientific research in this field is diversified.
AtıfScopus6WoS6OpenAlex6
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Editöre MektupYalnız künye2025Scopus SJRQ1/r/kostu/10660
Family Medicine Residents' Competency to Manage Oral Lesions: An Educational Intervention
Öçbe, Çetin Batuhan; Öçbe, Melisa; Akman, Mehmet
AtıfScopus1WoS1OpenAlex2
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MakaleAçık Erişim2025Scopus SJRQ1/r/kostu/10659
Assessing the reliability and educational value of YouTube videos on computer-controlled local anesthesia in dentistry
Akcay, Hulya Cerci; Kargu, Erdal Cem; Seker, Nefise
Objective This study aimed to assess the scientific accuracy, content quality, and educational value of YouTube™ videos related to computer-controlled local anesthesia (CCLA) techniques in dentistry. Materials and methods A total of 100 videos were screened using predefined keywords, and 48 met the inclusion criteria. Videos were assessed using the Global Quality Scale (GQS), DISCERN tool, JAMA benchmark criteria, and the Video Information and Quality Index (VIQI). Scientific content was scored using a structured rubric across six domains. Interobserver reliability was evaluated using Weighted Kappa and Intraclass Correlation Coefficient (ICC). Confidence intervals were calculated for key metrics. Group comparisons were performed using the Mann-Whitney U test, and correlations were analyzed using Spearman’s rho (p < 0.05). Results Videos from academic sources had significantly higher scores across all quality and reliability indicators. The mean GQS was 2.6 (95% CI: 2.3–2.9), DISCERN 11.7 (95% CI: 10.8–12.6), JAMA 1.8 (95% CI: 1.7–1.9), and VIQI 12.5 (95% CI: 11.7–13.3). Strong positive correlations were found between DISCERN and VIQI (r = 0.809), and between total content score and both DISCERN (r = 0.803) and VIQI (r = 0.655). Conclusion Although YouTube™ provides accessible information on CCLA, many videos lack scientific rigor and educational depth. Content produced by academic institutions is significantly more reliable. Dental educators are encouraged to integrate high-quality video content into curricula to improve media literacy and student learning outcomes.
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MakaleYalnız künye2025Scopus SJRQ2/r/kostu/10656
Verification of HPLC method to detect patulin levels and evaluation of exposure risk of patulin in apple-based products
Sanajou, Sonia; Girgin, Gözde; Şahin, Gönül; Baydar, Terken
Patulin, a mycotoxin produced by Penicillium, Aspergillus, and Byssochlamyces species, particularly in apple-based products, poses health risks, including cytotoxic, genotoxic, and immunotoxic effects. This study first validated an HPLC method to determine patulin levels. The validated method was then applied to 19 samples of fresh apples, commercial apple juices, and baby foods made from local apples. Method validation confirmed high accuracy (recovery = 87–93%), precision (CV < 2.6%), and sensitivity (LOD = 1.82 µg/L). All commercial juice samples complied with the EU regulatory limit (50 µg/L), indicating progress in industrial quality control. However, 67% of baby food samples contained detectable patulin, with one exceeding the EU infant food limit (10 µg/kg). Most notably, one fresh apple sample had 406 µg/kg of patulin—over 16 times the EU limit for solid apples (25 µg/kg), demonstrating the limitations of visual inspection for fungal contamination. These findings reveal ongoing risks in minimally processed products, especially for infants, and emphasise the need for improved post-harvest practices, stringent sorting, and broader monitoring. The study reflects global patterns, showing national improvement in juice safety but exposing critical gaps in the regulation of raw produce and infant food.
AtıfScopus1WoS1OpenAlex1
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MakaleYalnız künye2025Scopus SJRQ1/r/kostu/10648
The effect of chatbot-supported instruction on nursing students' history-taking questioning skills and stress level: A randomized controlled study
Kestel, Sıdıka; Çalık, Afra; Kuş, Mustafa
Background: Comprehensive history-taking is crucial for patient assessment, prioritisation of care, and planning of care. While direct instruction methods effectively explain history-taking processes and components, they provide insufficient opportunities for practice, necessitating the implementation of supplementary teaching strategies. Objective: This study aimed to examine the effects of AI chatbot-supported history-taking training on nursing students' questioning skills and clinical stress levels. Methods: This randomized controlled study with pretest-posttest was conducted with 82 “first-year” nursing students. The students were randomly assigned to either an intervention (n = 41) or a control (n = 41) group. The intervention group underwent history-taking using the traditional teaching method (theoretical training, watching a video, and clinical practice) plus an artificial intelligence (AI) chatbot; the students in the control group were trained only with the traditional method. Results: The intervention group demonstrated significantly superior performance in two specific components: history of present illness and review of systems (p < 0.05). Clinical stress levels showed mixed results, with significant differences in Challenge and Benefit subscales but no difference in overall stress scores between groups. Conclusion: Chatbot-based history-taking instruction is efficacious in improving students' history-taking questioning skills in specific components of history-taking, but not in clinical stress.
AtıfScopus13OpenAlex12
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MakaleAçık Erişim2025Scopus SJRQ1/r/kostu/10638
Psychometrics of the Attitude Scale towards the use of Artificial Intelligence Technologies in Nursing
Yılmaz, Dilek; Uzelli, Derya; Dikmen, Yurdanur
Background: It is clear that nursing practice is directly affected by artificial intelligence (AI), and in this regard, a need is felt for more information on the knowledge and attitudes of nurses to the use of AI technology in nursing care practice. However, no inclusive measurement instrument tested for validity and reliability evaluating the attitudes of nurses to the use of AI technology was found. The aim of this research was to develop and test the validity of the Attitude Scale Towards the Use of Artificial Intelligence Technologies in Nursing (ASUAITIN) in the Turkish language. Methods: The research was a methodological and cross-sectional study, designed to develop and test the validity of the ASUAITIN. STROBE guidelines were followed in the study. In order to create the starting materials, the researchers made a scan of the literature. Two hundred nurses working in the internal medicine, surgical and intensive care departments of a university hospital in the Marmara Region of Turkey were included in the study. Items were assessed for content validity. ASUAITIN was tested for construct validity and internal consistency reliability. Results: ASUAITIN consists of 15 items. It has two dimensions, positive attitude, and negative attitude to AI technology in nursing practice, and practice and explains 67.762% of total variance. Item loads were between 0.529 and 0.866. Cronbach alpha values were calculated to be 0.910 for the total scale, 0.933 for Factor 1, and 0.917 for Factor 2. Conclusions: The results of this study show that the ASUAITIN scale are validated and reliable measurement tool. ASUAITIN can be used as an instrument to assess the attitudes to AI technology in practice among nurses working in the clinical field. Clinical trial number: Not applicable.
AtıfScopus34WoS34OpenAlex36
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MakaleYalnız künye2025Scopus SJRQ2/r/kostu/10624
Synthesis, characterization and biological evaluation of new Coumarin-Ferrocene conjugates as antitumor agents
Taner, Bilge; Mahmood Mahmood, Aysha Hasan; Karakurt, Serdar; Altuner, Elif Esra; Dar, Umar Ali
Two novel ferrocene-appended coumarin derivatives, FcL1 and FcL2, were synthesized and characterized using various analytical techniques which includes IR, UV, 1H NMR, 13C NMR and mass spectroscopy. 1H NMR revealed signals for the substituted cyclopentadiene ring at δ 4.80 and δ 4.61 ppm (FcL1) and δ 4.81 and 4.60 ppm (FcL2), while 13C NMR confirmed azomethine carbons at δ 162.95 and 160.43 ppm, respectively. UV–Vis analysis confirmed the successful molecular design of FcL1 and FcL2, achieving the desired electronic properties. Cytotoxic and antiproliferative effects of FcL1 and FcL2 were evaluated against metastatic colorectal carcinoma (CRC) DLD-1 cells and healthy colon epithelium CCD-18Co cells using the Alamar Blue assay. Both compounds inhibited DLD-1 cell proliferation in a dose-dependent manner, with IC50 values of 64.3 ± 2.4 µM (FcL1) and 67.1 ± 3.1 µM (FcL2). Minimal cytotoxic effects were observed on healthy colon epithelial cells at the same concentrations (p < 0.001). Fluorescence microscopy revealed the localization of both compounds in the cytoplasm and nucleus of cells. These findings suggest FcL1 and FcL2 as potential candidates for colorectal cancer therapy, exhibiting selective cytotoxicity toward cancer cells with low toxicity to healthy cells.
AtıfScopus8WoS6OpenAlex7
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MakaleAçık Erişim2025Scopus SJRQ2/r/kostu/10620
Effects of Rapid Maxillary Expansion on Pulmonary Function in Adolescents: A Spirometric Evaluation
Akbulut, Yasin; Oksayan, Rıdvan; Sokucu, Oral; Isman, Nurettin Eren; Demir, Tuncer
Objectives: Rapid maxillary expansion (RME) is widely used in orthodontics to correct transverse maxillary deficiencies. Beyond its skeletal and dental effects, RME may influence upper airway dimensions and respiratory function, particularly in growing individuals. This study aimed to evaluate the impact of RME on pulmonary function in adolescents using spirometric measurements. Materials and Methods: Fifteen adolescent patients (8 females, 7 males; mean age: 13.93 ± 2.89 years) diagnosed with maxillary transverse constriction underwent orthodontic treatment with acrylic-bonded RME appliances over a mean duration of 3.56 ± 0.67 months. Respiratory function was assessed via spirometry at baseline (T0) and one day after appliance removal (T1). Parameters recorded included peripheral oxygen saturation (SpO2), forced expiratory volume in one second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, and vital capacity (VC). Data were analyzed using the paired-samples t-test (for normally distributed variables) or the Wilcoxon signed-rank test (for non-normal distributions), with statistical significance set at p < 0.05. Results: Following RME treatment, all respiratory parameters showed a consistent upward trend but did not reach statistical significance. SpO2 increased from 96.98 ± 0.96% to 97.01 ± 0.98% (p = 0.925). VC rose from 2.86 ± 1.07 L to 3.03 ± 0.80 L (p = 0.626). The FEV1/FVC ratio improved from 90.88 ± 12.17% to 92.34 ± 7.37% (p = 0.742). Mean FEV1 increased from 2.61 ± 0.72 L to 2.72 ± 0.68 L (p = 0.518), while FVC rose from 2.87 ± 0.75 L to 2.96 ± 0.69 L (p = 0.547). No adverse effects were reported during the treatment period. Conclusions: This study identified a non-significant but consistent trend toward improved pulmonary function following RME in adolescents. These preliminary findings should be considered hypothesis-generating rather than confirmatory evidence, as none of the outcomes reached statistical significance. While the observed upward trends in oxygen saturation, lung volumes, and expiratory performance suggest potential respiratory benefits, larger-scale, controlled, and long-term studies incorporating both spirometric and anatomical airway assessments are needed to validate these observations.
AtıfScopus2OpenAlex1
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MakaleAçık Erişim2025Scopus SJRQ2/r/kostu/10613
Magnetic Resonance Imaging of Submental and Masticatory Muscle Morphology and Its Relationship with Temporomandibular Joint Structures
Öçbe, Melisa; Medişoğlu, Mahmut Sabri
Introduction: This study aimed to evaluate the submental and masticatory muscles in patients of different age groups using magnetic resonance imaging (MRI) and computed tomography (CT) methods, and investigate potential associations between muscle morphology, temporomandibular joint (TMJ) structures, and disc displacement. Materials and Methods: A total of 185 MRI scans were retrospectively analyzed to assess the thickness of the digastric, geniohyoid, mylohyoid, medial pterygoid, masseter, and lateral pterygoid muscles bilaterally. TMJ hard tissue changes were classified using computed tomography (CT). Correlations between muscle thickness and TMJ structures were analyzed using Pearson correlation coefficients, with statistical significance set at p < 0.05. Results: The study population included 110 females and 75 males, with a mean age of 50.08 ± 20.15 years. The largest age group was 51–75 years (41%), followed by 18–35 years (28%). Significant correlations were observed between muscle thickness and TMJ structures as follows: Right digastric muscle showed a significant association with right disc–condyle position (p = 0.02). Right mylohyoid muscle exhibited a strong correlation with right disc–condyle position (p = 0.004). Left medial pterygoid muscle was significantly correlated with left condyle pathology (p = 0.02). Left masseter muscle showed a significant correlation with left condyle pathology (p = 0.014). Condylar flattening was the most frequent pathology, observed in 58% of right condyles and 53% of left condyles. Disc displacement was present in 41% of right TMJs and 34% of left TMJs. Conclusions: This study highlights the important associations between masticatory and submental muscle morphology and TMJ structures, suggesting that muscle function may play a role in condylar positioning and disc alignment. These findings emphasize the need for comprehensive muscle evaluation in TMJ disorder (TMD) diagnosis and treatment planning.
AtıfScopus2WoS2OpenAlex2
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Derleme MakaleAçık Erişim2025Scopus SJRQ2/r/kostu/10607
The evolving role of MRI in dentomaxillofacial diagnostics: a comprehensive review
Öçbe, Melisa
Magnetic Resonance Imaging (MRI) has emerged as a pivotal diagnostic tool in dentomaxillofacial radiology, surpassing conventional imaging techniques by offering superior contrast resolution for soft tissue lesions without the use of ionizing radiation. This comprehensive review explores the expanding applications of MRI in dentistry, highlighting its integration into routine diagnostic protocols and its significance in the evaluation of oral and maxillofacial structures. The article delves into the physics of MRI, detailing the various sequences such as Spin Echo (SE), Gradient Echo (GRE), and Short-Tau Inversion Recovery (STIR), each tailored for specific diagnostic needs. Advanced techniques like Dynamic Contrast-Enhanced MRI and Diffusion-Weighted Imaging (DWI) are discussed for their roles in assessing tissue perfusion and differentiating between benign and malignant lesions. The review emphasizes the necessity of appropriate coil selection and parameter optimization to enhance image quality, particularly in dental applications where artifacts from restorative and prosthetic materials can pose challenges. Furthermore, the article addresses the utility of MRI in visualizing dental hard tissues, the temporomandibular joint, and neurovascular structures, providing a comprehensive overview of its diagnostic capabilities. The integration of MRI into global health systems and the role of Personal Electronic Health Records in reducing redundant imaging are also examined. Conclusively, the review underscores the transformative impact of MRI on dentomaxillofacial diagnostics, advocating for its broader adoption in clinical practice to facilitate accurate diagnosis and effective treatment planning.
AtıfScopus8OpenAlex4
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MakaleYalnız künye2025Scopus SJRQ2/r/kostu/10606
Multimodal Imaging of the Nasopalatine Canal: Morphometric Characteristics and Signal Intensity Assessment
Öçbe, Melisa; Medişoğlu, Mahmut Sabri
Objective: – The nasopalatine canal (NPC) is an essential anatomical structure in the anterior maxilla, linking the nasal and oral cavities. Its morphology is critical for oral surgery, anesthesia, and implant planning. This study aimed to provide a comprehensive evaluation of the NPC by combining computed tomography (CT) and magnetic resonance imaging (MRI) to assess canal morphology and signal characteristics. Methods: – A total of 346 CT and MRI images from patients aged 18 years and older (173 males, 173 females; mean age 53.35 ± 19.8 y) were analyzed. Axial and coronal MRI and sagittal CT sections were evaluated for canal shape, number, length, and signal intensity. Results: – The mean lengths of the incisive and nasopalatine foramina were found as 6.66 ± 2.2 mm and 3.2 ± 1.5 mm, respectively. Axial canal shapes were predominantly round or oval (63.01%), while 47.69% exhibited a Y-shaped configuration in the coronal plane. Anterior tooth loss was present in 39.5% of patients and was significantly associated with changes in foramen dimensions (P < 0.001). The mean FLAIR T2 MRI signal intensities for the incisive and nasopalatine foramina were 643.64 ± 246.38 and 585.46 ± 214.27, respectively. Diagnostic thresholds for normal signal intensity were calculated as 1.136 for the incisive foramen and 1.013 for the nasopalatine foramen. Conclusions: – These findings suggest that FLAIR T2 MRI signal intensity may serve as a diagnostic marker for NPC assessment. Furthermore, anterior tooth loss appears to influence the dimensions of the incisive foramen. Future studies should validate these MRI thresholds and explore longitudinal changes in NPC morphology.
AtıfScopus2WoS2OpenAlex2
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BildiriYalnız künye2025/r/kostu/10583
Hand vein recognition using Mask R-CNN
Kiyak, Mehmeat; Savas, Burcu Kir; Akdeniz, Fulya
Medical imaging technologies play a crucial role in critical applications such as dorsal hand vein detection. Traditional methods for locating veins can pose challenges in treatment and diagnosis, particularly for children, elderly individuals, obese patients, and individuals with darker skin tones. In this study, an automatic dorsal hand vein detection system was developed using a deep learning-based Mask R-CNN model for dorsal hand vein segmentation. A dataset provided by Boǧaziçi University, consisting of 1,575 dorsal hand vein images collected from 100 individuals, was utilized. To enhance vein structures, contrast-enhancing image processing techniques were applied, and the vein networks were manually annotated in detail. The Mask R-CNN model was then trained on this dataset to perform segmentation, and its accuracy was optimized. The study achieved an accuracy rate of 75.3%. The obtained results demonstrate the potential of this method to provide a practical and reliable solution in clinical settings..
AtıfWoS1OpenAlex1
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MakaleYalnız künye2025Scopus SJRQ2/r/kostu/10570
The prognostic value of the MAGGIC risk score in patients with acute pulmonary embolism
Artac, Inanc; Ilis, Dogan; Karakayali, Muammer; Omar, Timor; Arslan, Ayca; Topaloğlu, Ihsan; Karabag, Yavuz; Karakayon, Suleyman; Rencuzogullari, Ibrahim
Objectives: Acute pulmonary embolism (PE) is a potentially life-threatening condition characterized by the sudden blockage of the pulmonary arteries. Although the MAGGIC risk score has emerged as a valuable tool in predicting outcomes in patients with chronic heart failure, it has also been demonstrated and identified as a prognostic model in various cardiac diseases other than heart failure. In this study, we aimed to investigate the relationship between MAGGIC score and adverse outcomes in patients with PE. Materials and Methods: A total of 302 consecutive patients diagnosed with acute PE were retrospectively included in the present study. For each patient, the MAGGIC score was calculated. The study population was divided into two groups according to the median value of MAGGIC score. Results: Patients with high MAGGIC score had a significantly higher proportion of elderly and female individuals, lower BMI, higher presence of CAD, DM, AFib, HF, HT, CKD, COPD, and ACEI/ARB and NOAC usage. Logistic regression analyses was carried out using univariate and multivariate analysis to predict the in-hospital and 30-day mortality predictors in the included PE patients. For in-hospital mortality, diastolic blood pressure, heart rate, RV dilatation, and the MAGGIC score (HR: 1.166, 95% CI 1.077–1.263, p < 0.001) and for short-term mortality, sPESI and the MAGGIC score (HR: 1.925, 95% CI 1.243–2.983, p:0.003) were found to be independent predictors for adverse outcomes in patients with acute PE. Conclusion: Our study demonstrates that the MAGGIC score can be applied as a valuable prognostic tool for acute pulmonary embolism.
AtıfScopus6WoS4OpenAlex6
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MakaleYalnız künye2025Scopus SJRQ2/r/kostu/10568
Therapeutic potential of adult stem cells-derived mitochondria transfer combined with curcumin administration into ARPE-19 cells in age-related macular degeneration model
Kılıç, Kamil Can; Duruksu, Gökhan; Öztürk, Ahmet; Rençber, Selenay Furat; Kılıç, Buket; Yazır, Yusufhan
Objective: Mitochondria transfer from human Wharton's Jelly-derived mesenchymal stem cells (hWJ-MSCs-mt) and human endometrium-derived mesenchymal stem cells (hE-MSCs-mt), along with curcumin, were explored as potential treatments for age-related macular degeneration (AMD) caused by mitochondrial inefficiency, using a retinal model to assess impacts of curcumin and hWJ-MSCs-mt or hE-MSCs-mt on AMD. Methods: ARPE-19 cells established an in vitro AMD model. Cells were exposed to 0–50 μM curcumin for 24 hours to determine optimal concentration by assessing their viability. Immunofluorescence examined SOD1, TNF-α, and TGF-β levels at optimal hydrogen peroxide (H2O2) concentration. β-galactosidase staining and DCFH analysis evaluated H2O2-induced cellular senescence. Immunofluorescence assessed REP65, CRALBP1 (RLBP1), Pink1, and Parkin expression, whereas qRT-PCR analyzed Nrf2, Ire1a, ARMS2, HTRA1, RPE65, RLBP1, NOX4, and TOMM20 expression following co-treatment with curcumin and hWJ-MSCs-mt or hE-MSCs-mt. Results: Curcumin improved ARPE-19 cell survival under H2O2-induced oxidative stress by regulating SOD1, TNF-α, TGF-β, DCFH, and MDA levels. hWJ-MSCs-mt transfer increased RLBP1 and Parkin expression, whereas curcumin reduced Parkin expression. hE-MSCs-mt transfer upregulated Parkin, RPE65, Pink1, and RLBP1 expressions, with curcumin enhancing RPE65 expression. hWJ-MSCs-mt and curcumin combined more effectively downregulated expressions of stress-related genes (Nrf2, Ire1α, NOX4) and improved expression of mitochondrial function gene (TOMM20). hE-MSCs-mt transfer with curcumin synergistically enhanced expression of retinal health markers (RPE65, RLBP1) and downregulated expression of damage-associated genes (HTRA1, ARMS2) in AMD models. Conclusion: Curcumin combined with hWJ-MSCs-mt or hE-MSCs-mt is a potential AMD therapy owing to its anti-inflammatory properties; however, further in vivo and human studies are needed to confirm its efficacy and safety.
AtıfScopus12WoS12OpenAlex15
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MakaleAçık Erişim2025Scopus SJRQ3/r/kostu/10555
The Efficacy and Safety of Hepatitis A Vaccine in Children and Young Adults With an Autoinflammatory Diseases on Canakinumab and Tocilizumab Treatments: A Prospective Observational Controlled Study
Barut, Kenan; Yildiz, Mehmet; Beşer, Ömer Faruk; Haslak, Fatih; Gunalp, Aybuke; Konte, Elif Kılıç; Aslan, Esma; Gül, Ümit; Akay, Nergis; Adrovic, Amra
Intro: In this prospective interventional study, we aimed to assess the efficacy and safety of the hepatitis A vaccine in patients with autoinflammatory diseases undergoing canakinumab and tocilizumab treatments. Methods: A total of 24 patients with autoinflammatory diseases on canakinumab and tocilizumab treatments and 39 healthy children who were seronegative for hepatitis A were included in the study. All participants were vaccinated with 2 doses of inactivated hepatitis A vaccine at 6-month intervals. One month after the last vaccination, venous blood samples were collected from each participant, and the anti-HAV IgM and IgG titers were measured. Results: The patient group consisted of 19 patients with systemic juvenile idiopathic arthritis (sJIA) and 5 patients with cryopyrin-associated periodic fever. The mean age of the patient group and the healthy controls were 14.1 ± 3.7 and 12.4 ± 3.2 years, respectively. All patients with cryopyrin-associated periodic fever and 52.6% (10/19) of the patients with sJIA were on canakinumab. The remaining 9 patients (47.3%) with sJIA were using tocilizumab. Among sJIA patients, 15 were also on methotrexate, and 14 were on prednisolone. All of the participants were negative for hepatitis A serology. After two doses of hepatitis A vaccine, all the patients with autoinflammatory diseases (24/24) and 84.6% (33/39) of the healthy controls were detected as positive for anti-HAV IgG (p = 0.04). The mean anti-HAV Ig G titers of the patient group and the control group one month after the last dose of vaccination were 5.25 ± 1.49 IU/L and 10.5 ± 7.02 IU/L, respectively (p < 0.001). Neither disease flares nor adverse effects related to vaccination were observed within the study period. Conclusion: Hepatitis A vaccine is effective and safe in children with autoinflammatory diseases on biologic therapy. Long-term follow-up data, including larger patient cohorts, are needed to draw a solid conclusion about the safety of hepatitis A vaccine in patients receiving canakinumab and tocilizumab therapy.
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MakaleAçık Erişim2025Scopus SJRQ1/r/kostu/10550
A comparison of 3D game-based simulation versus traditional methods in vital signs education
Tanrıkulu, Fatma; Gündoğdu, Handenur; Erol, Funda; Dikmen, Yurdanur
Background: Vital signs measurement is a fundamental nursing responsibility that requires cognitive and psychomotor competence. In alignment with the ethical principle of nonmaleficence, it is important to provide learning environments where students can practice and make mistakes without causing harm. This study aims to examine the effect of a 3D game-based simulation application developed for vital signs on students’ academic achievement, learning satisfaction and self-confidence levels. Methods: A randomized controlled experimental design was employed with 73 nursing students, assigned to either the intervention group (n = 37) or the control group (n = 36). The intervention group used a game-based simulation developed with 3D animation technology, while the control group received traditional instruction. Data were collected using the Student Introductory Characteristics Form, Academic Achievement Test of Vital Signs Measurement Skills, and the Student Satisfaction and Self-Confidence in Learning Scale. Statistical analyses were conducted using SPSS version 25, with significance set at p < 0.05. Results: The results indicated that students’ current learning satisfaction subscale scores were high in the traditional teaching group and that there was a statistically significant difference between the groups (p = 0.047). There was no statistically significant difference between the groups in terms of academic achievement (p = 0.932) and self-confidence levels in learning (p = 0.375). However, both groups had high mean scores in academic achievement, satisfaction with current learning, and self-confidence in learning. Conclusions: The game simulation method supported by 3D animation may be insufficient for significantly improving nursing students’ academic performance, satisfaction with the learning process, and self-confidence in learning. Therefore, it is recommended that such technology-supported methods be used in blended learning environments alongside traditional teaching methods in nursing education. Trial registration: ClinicalTrials.gov: NCT07009275; retrospectively registered.
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